◀ Back to TP53

ING1 — TP53

Pathways - manually collected, often from reviews:

• WikiPathways Senescence and Autophagy in Cancer: ING1 → TP53 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: ING1 — TP53 Leung et al., Cancer Res 2002*
• IRef Bind_translation Interaction: ING1 — TP53 (coimmunoprecipitation) Leung et al., Cancer Res 2002*
• IRef Biogrid Interaction: TP53 — ING1 (physical association, affinity chromatography technology) Zhu et al., Hepatology 2009*
• IRef Biogrid Interaction: TP53 — ING1 (physical association, affinity chromatography technology) Leung et al., Cancer Res 2002*
• IRef Biogrid Interaction: TP53 — ING1 (physical association, affinity chromatography technology) Garkavtsev et al., Nature 1998*
• IRef Hprd Interaction: TP53 — ING1 (in vitro) Leung et al., Cancer Res 2002*, Garkavtsev et al., Nature 1998*
• IRef Hprd Interaction: TP53 — ING1 (in vivo) Leung et al., Cancer Res 2002*, Garkavtsev et al., Nature 1998*
• IRef Intact Interaction: Complex of TP53-UBC-ING1 (association, pull down) Garate et al., EMBO Rep 2008*
• IRef Ophid Interaction: ING1 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: ING1 — TP53 (aggregation, confirmational text mining) Leung et al., Cancer Res 2002*

Text-mined interactions from Literome

Leung et al., Cancer Res 2002 (Carcinoma, Non-Small-Cell Lung...) : The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2 ... Here we show that ING1b could stimulate the activity of p53 by increasing the level and stability of the p53 protein ... The stabilization and activation of p53 by ING1b could be reversed by MDM2 in a dose dependent manner ... These data suggest a model in which ING1b disrupts the interaction between p53 and MDM2, leading to the stabilization of p53 and growth inhibition
Coles et al., Cancer Res 2007 (Cell Transformation, Neoplastic) : In this study, we have generated and analyzed p37 ( Ing1 ) -deficient mice and primary cells to further explore the role of Ing1 in the regulation of cell growth and p53 activity
Abad et al., J Biol Chem 2007 (Cell Transformation, Neoplastic) : Ing1 mediates p53 accumulation and chromatin modification in response to oncogenic stress
Thalappilly et al., PloS one 2011 : ING1 expression stabilized wild-type, but not mutant p53 in an MDM2 independent manner and knockdown of endogenous ING1 depressed p53 levels in a transcription independent manner ... These data link lipid stress signaling to ubiquitin mediated proteasomal degradation through the PBR/UBD of ING1 and further indicate that ING1 stabilizes p53 by inhibiting polyubiquitination of multimonoubiquitinated forms via interaction with and colocalization of the HAUSP-deubiquitinase with p53