Kim et al., J Korean Med Sci 2002
(MAP Kinase Signaling System) :
These results suggest that the IL-1beta mediated MUC2 gene expression and mucin secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway, and that PI3K is also involved in the IL-1beta mediated MUC2 gene expression and mucin secretion
Kim et al., Biochem Biophys Res Commun 2012
:
HMGB1 activated the JNK and PI3K/Akt signaling pathways, and inhibitors of JNK and PI3K/Akt markedly inhibited HMGB1 induced MUC8 expression