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BMP2 — CDKN1A

Text-mined interactions from Literome

Yamato et al., Exp Cell Res 2000 : In this study, we show that BMP-2 did not alter expression of cyclin D, cyclin E, cyclin dependent kinase 2 (CDK2), CDK4, p27KIP1, p16INK4a, or p15INK4b, but enhanced expression of p21 ( CIP1/WAF1 )
Ghosh-Choudhury et al., Biochem Biophys Res Commun 2000 (Breast Neoplasms) : BMP-2 increases the level of cyclin kinase inhibitor p21
Ghosh-Choudhury et al., Biochim Biophys Acta 2000 (Breast Neoplasms) : Bone morphogenetic protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol treated MCF-7 human breast cancer cells
Yamato et al., Oncogene 2001 : Activation of the p21 ( CIP1/WAF1 ) promoter by bone morphogenetic protein-2 in mouse B lineage cells ... In the present study, we demonstrated that BMP-2 activated the mouse p21 ( CIP1/WAF1 ) promoter in HS-72 cells, and that a 29-base pair ( b ) region of the promoter ( -1928/-1900 relative to the TATA box ), conserved between mice and humans, was responsive to BMP-2 as well as expression of Smad1, Smad4, and constitutively active mutants of BMP type I receptors ... These results suggested that BMP-2 might activate p21 ( CIP1/WAF1 ) transcription by inducing a binding of Smad4 and Smad1 to the 29-b region in HS-72 cells
Carlberg et al., Differentiation 2001 : Infection of C3HIOT1/2 cells with this retroviral construct resulted in an infection efficiency of 90-95 % and was highly effective in converting cells in micromass culture to a chondrocyte phenotype, as assessed by positive Alcian blue staining for extracellular matrix proteoglycans, increased sulfate incorporation, increased expression of the cartilage marker genes collagen type II and aggrecan, and decreased expression of collagen type I. Interestingly, BMP-2 expression in the micromass cultures also induced the expression of the cell cycle inhibitory protein/differentiation factor p21/WAF1 , suggesting its functional involvement in chondrogenesis
Pouliot et al., J Endocrinol 2002 (Breast Neoplasms) : Role of Smad1 and Smad4 proteins in the induction of p21WAF1,Cip1 during bone morphogenetic protein induced growth arrest in human breast cancer cells ... Better to understand the mechanism of BMP induced growth arrest we examined the effect of BMP-2 and mediators of BMP-2 action on cell proliferation and p21 ( Cip1 ) expression in breast cancer cell lines ... p21 promoter activity required both Smad1 and Smad4 and was induced by either BMP-2 or constitutively active type I BMP receptors ... Moreover, the C-terminal SSVS region of Smad1 was necessary for activation of the p21 promoter by BMP-2 ... Taken together, these results indicate that the mechanism of BMP induced p21 promoter activation involves BMP receptors and BMP Smads
Wen et al., Biochem Biophys Res Commun 2004 (Stomach Neoplasms) : BMP-2 increased the level of p21/WAF1/CIP1 , suggesting that BMP-2 mediated inhibition of cell proliferation may be induced through p21/WAF1/CIP1
Tomari et al., Int J Mol Med 2005 (Prostatic Neoplasms) : Furthermore, BMP-2 induced expression of p21 ( WAF1/CIP1 ), a CDK inhibitor
Pardali et al., J Cell Physiol 2005 : Signaling studies with all type I receptors of the TGF-beta superfamily show that BMP receptors induce higher p21 expression than TGF-beta/activin receptors ... Based on the previously known ability of c-Myc to block p21 expression and epithelial growth arrest in response to TGF-beta1, we demonstrate that ectopic c-Myc expression can abrogate Smad mediated p21 induction by all TGF-beta and BMP receptors
Yin et al., J Virol 2010 : Further, miR-155 inhibits SMAD1 and SMAD5 expression in the lung epithelial cell line A549, it inhibits BMP mediated induction of the cyclin dependent kinase inhibitor p21 , and it reverses BMP mediated cell growth inhibition
Jernvall et al., Development 1998 : The life history of an embryonic signaling center : BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot