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JUN — SIRT1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Gao et al., Biochem Biophys Res Commun 2008
:
However, it is not clear if
SIRT1 regulates
c-JUN activity in the control of gene transcription ... Here, we show that
SIRT1 associated with c-JUN in co-immunoprecipitation of whole cell lysate, and
inhibited the transcriptional activity of
c-JUN in the mammalian two hybridization system ... These data consistently suggest that
SIRT1 directly
inhibits the transcriptional activity of
AP-1 by targeting c-JUN
Zhang et al., J Biol Chem 2010
:
Here we demonstrate that SIRT1 directly interacts with the basic leucine zipper domains of c-Fos and c-Jun, the major components of AP-1, by which
SIRT1 suppressed the transcriptional activity of
AP-1
Gao et al., J Biol Chem 2011
(Fatty Liver...) :
Sirtuin 1 (SIRT1) protein degradation in
response to persistent
c-Jun N-terminal kinase 1 ( JNK1 ) activation contributes to hepatic steatosis in obesity
Kuroda et al., Proc Natl Acad Sci U S A 2011
:
BATF, together with
c-Jun , transcriptionally
inhibited expression of the nicotinamide adenine dinucleotide ( NAD ( + ) ) -dependent deacetylase
Sirt1 , resulting in increased histone acetylation of the T-bet locus and increased cellular NAD ( + ), which increased ATP production