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SIRT1 — WRN
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
WRN
—
SIRT1
(physical association, affinity chromatography technology)
Law et al., Proteomics 2009
-
IRef Intact Interaction:
Complex of 25 proteins
(physical association, pull down)
Law et al., Proteomics 2009
-
IRef Intact Interaction:
Complex of SIRT1-CREBBP-WRN
(association, anti bait coimmunoprecipitation)
Li et al., J Biol Chem 2008*
-
IRef Intact Interaction:
WRN
—
SIRT1
(physical association, anti tag coimmunoprecipitation)
Li et al., J Biol Chem 2008*
-
IRef Intact Interaction:
WRN
—
SIRT1
(direct interaction, pull down)
Li et al., J Biol Chem 2008*
-
IRef Intact Interaction:
WRN
—
SIRT1
(direct interaction, deacetylase assay)
Li et al., J Biol Chem 2008*
-
IRef Intact Interaction:
WRN
—
SIRT1
(physical association, anti bait coimmunoprecipitation)
Li et al., J Biol Chem 2008*
-
IRef Intact Interaction:
Complex of ACACA-WRN-SIRT1
(physical association, anti tag coimmunoprecipitation)
Law et al., Proteomics 2009
Text-mined interactions from Literome
Li et al., J Biol Chem 2008
(Aging, Premature...) :
Down-regulation of
SIRT1 reduces
WRN translocation from nucleoplasm to nucleoli after DNA damage
Michishita et al., Nature 2008
(Werner Syndrome) :
At telomeric chromatin,
SIRT6 deacetylates H3K9 and is
required for the stable association of
WRN , the factor that is mutated in Werner syndrome