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GAL — ODC1

Text-mined interactions from Literome

Endo et al., Br J Pharmacol 1992 (Drug-Induced Liver Injury) : Since LPS and these cytokines induce ornithine decarboxylase (ODC) and histidine decarboxylase (HDC) in the liver and spleen of mice, the effects of GalN on the induction of ODC and HDC in these organs were examined ... 2. The induction of ODC by LPS, IL-1 or TNF was suppressed by GalN in the liver, and this suppression preceded the hepatic congestion ... An injection of uridine, the precursor of UTP, diminished the GalN induced suppression of ODC induction by LPS and prevented the hepatic congestion and death ... Although GalN in combination with IL-la induced a markedly higher HDC activity than was observed when it was combined with TNFa, and suppressed the induction of ODC , the former combination at the doses used did not produce hepatic congestion or death
Putnam et al., Surgery 1984 (Drug-Induced Liver Injury...) : Hepatic neutral serine proteases ( including plasminogen activator ) and ornithine decarboxylase (ODC) are induced by the hepatotoxin galactosamine (GALN)