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PARP1 — SELE

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SELE → PARP1 (increases) Piconi et al., Journal of thrombosis and haemostasis : JTH 2004*
  Evidence: Pharmacological inhibition of PARP suppressed both nitrotyrosine formation, adhesion molecule expression and IL-6 to the levels seen in the normal glucose conditions.

Text-mined interactions from Literome

Sharp et al., Inflammation 2001 (Inflammation) : Enzyme linked immunosorbent analysis ( ELISA ) was used to assess if ICAM-1, VCAM-1, and E-selectin were expressed at the cell surface, and if PARP inhibition ( using the selective PARP inhibitor GPI 6150 ) blocked the induced expression ... PARP inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression, and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h
von Lukowicz et al., Cardiovasc Res 2008 (Atherosclerosis...) : PARP inhibition or PARP1 deletion reduced PARP activity and diminished expression of inducible nitric oxide synthase, vascular cell adhesion molecule-1, and P- and E-selectin