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TCF4 — VHL

Text-mined interactions from Literome

Ivanova et al., J Mol Biol 2004 : STRA13 is a pVHL dependent bHLH transcription factor up-regulated on the mRNA level in multiple cancer cell lines and implicated recently in the regulation of immune cell homeostasis and autoimmunity
Giles et al., Oncogene 2006 (Adenocarcinoma...) : Here, we show that VHL expression is regulated by TCF4 and is restricted to the proliferative compartment at the bottom of intestinal crypts
Peruzzi et al., Proc Natl Acad Sci U S A 2006 (Carcinoma, Renal Cell...) : VHL gene silencing in non-RCC renal epithelial cells phenotypically mimicked VHL loss in RCC, and HGF-driven invasiveness was blocked by the expression of a dominant negative mutant of Tcf
Zehetner et al., Genes Dev 2008 : von Hippel-Lindau (VHL) tumor suppressor protein, pVHL, negatively regulates hypoxia-inducible factor HIF1alpha, a transcription factor implicated in promoting a glycolytic form of metabolism
Shen et al., Cancer Discov 2011 (Carcinoma, Renal Cell...) : pVHL inhibits the hypoxia-inducible transcription factor ( HIF ), and HIF2a is a kidney cancer oncoprotein