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CAPN6 — MYC

Text-mined interactions from Literome

Small et al., Arch Biochem Biophys 2002 (Cell Transformation, Neoplastic...) : These studies support a role for calpain in the control of c-Myc levels in vivo, and suggest that mutations impacting on sensitivity to calpain may contribute to c-Myc mediated tumorigenesis
Niapour et al., J Biol Chem 2008 : Regulation of calpain activity by c-Myc through calpastatin and promotion of transformation in c-Myc negative cells by calpastatin suppression ... c-Myc stimulated calpain activity by suppressing calpastatin expression, the endogenous calpain inhibitor
Mousavi et al., Science signaling 2010 (Neoplasms) : A cytoplasmic variant of c-Myc called `` Myc-nick, '' which arises from calpain mediated cleavage of c-Myc , assists in stable microtubule assembly
Conacci-Sorrell et al., Cell cycle (Georgetown, Tex.) 2011 : Here we discuss the roles and regulation of full-length Myc and Myc-nick in terminal differentiation and propose a model in which calpain mediated cleavage of Myc operates as a functional switch