◀ Back to NOS3
NOS3 — SP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Cieslik et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
Our recent study indicates that lysophosphatidylcholine ( LPC ) enhances Sp1 binding and
Sp1 dependent
endothelial nitric oxide synthase (eNOS) promoter activity via the mitogen activated protein kinase/extracellular signal regulated kinase kinase 1 ( MEK-1 ) signaling pathway ( Cieslik, K., Lee, C.-M., Tang, J.-L., and Wu, K. K. ( 1999 ) J. Biol. Chem. 274, 34669-34675 ) ... These results indicate that LPC enhances
Sp1 dependent
eNOS promoter activity by a pertussis toxin-sensitive, Ras independent novel pathway, PI-3Kgamma/Jak2/MEK-1/ERK1/2
Gan et al., J Biol Chem 2005
:
The induction of
eNOS by inhibition of HDACs in non-endothelial cells, however, appeared not
mediated by the changes in
Sp1 DNA binding activity
Kumar et al., DNA Cell Biol 2009
:
As previously reported, mutation of the Sp1 consensus lead to the complete loss of eNOS promoter activity, confirming the key
role of
Sp1 in regulating basal
eNOS promoter activity
Tang et al., Biochem Biophys Res Commun 1995
:
Role of
Sp1 in transcriptional activation of human
nitric oxide synthase type III gene