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ERCC4 — SLX4
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
ERCC4
—
SLX4
(physical association, affinity chromatography technology)
Kim et al., Blood 2013*
-
IRef Biogrid Interaction:
ERCC4
—
SLX4
(physical association, affinity chromatography technology)
Svendsen et al., Cell 2009
-
IRef Biogrid Interaction:
ERCC4
—
SLX4
(physical association, affinity chromatography technology)
Kim et al., Nat Genet 2011*
-
IRef Biogrid Interaction:
ERCC4
—
SLX4
(physical association, affinity chromatography technology)
Ghosal et al., J Biol Chem 2012
-
IRef Biogrid Interaction:
ERCC4
—
SLX4
(direct interaction, pull down)
Muñoz et al., Mol Cell 2009
-
IRef Biogrid Interaction:
ERCC4
—
SLX4
(direct interaction, two hybrid)
Muñoz et al., Mol Cell 2009
-
IRef Biogrid Interaction:
ERCC4
—
SLX4
(direct interaction, two hybrid)
Andersen et al., Mol Cell 2009*
-
IRef Biogrid Interaction:
ERCC4
—
SLX4
(colocalization, biochemical)
Muñoz et al., Mol Cell 2009
-
IRef Biogrid Interaction:
ERCC4
—
SLX4
(direct interaction, two hybrid)
Fekairi et al., Cell 2009
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Fekairi et al., Cell 2009
-
IRef Hprd Interaction:
ERCC4
—
SLX4
(in vivo)
Fekairi et al., Cell 2009
-
IRef Hprd Interaction:
ERCC4
—
SLX4
(two hybrid)
Fekairi et al., Cell 2009
-
IRef Intact Interaction:
Complex of 26 proteins
(association, anti tag coimmunoprecipitation)
Svendsen et al., Cell 2009
-
IRef Intact Interaction:
Complex of TERF2-ERCC1-SLX4-ERCC4
(association, anti tag coimmunoprecipitation)
Fekairi et al., Cell 2009
-
IRef Intact Interaction:
Complex of 58 proteins
(association, anti tag coimmunoprecipitation)
Svendsen et al., Cell 2009
-
IRef Intact Interaction:
Complex of SLX4-PLK1-ERCC4
(association, anti tag coimmunoprecipitation)
Svendsen et al., Cell 2009
-
IRef Intact Interaction:
Complex of 18 proteins
(association, anti tag coimmunoprecipitation)
Svendsen et al., Cell 2009
-
IRef Intact Interaction:
Complex of 49 proteins
(association, anti tag coimmunoprecipitation)
Svendsen et al., Cell 2009
-
IRef Intact Interaction:
Complex of ERCC4-ERCC1-SLX4
(association, anti tag coimmunoprecipitation)
Fekairi et al., Cell 2009
-
IRef Intact Interaction:
Complex of SLX4-TERF2-ERCC4
(association, anti bait coimmunoprecipitation)
Svendsen et al., Cell 2009
-
IRef Intact Interaction:
Complex of ERCC4-SLX4-SLX1A-SLX1B
(physical association, anti tag coimmunoprecipitation)
Fekairi et al., Cell 2009
-
IRef Intact Interaction:
ERCC4
—
SLX4
(physical association, anti bait coimmunoprecipitation)
Svendsen et al., Cell 2009
-
IRef Intact Interaction:
ERCC4
—
SLX4
(physical association, anti tag coimmunoprecipitation)
Svendsen et al., Cell 2009
-
IRef Intact Interaction:
ERCC4
—
SLX4
(physical association, two hybrid)
Fekairi et al., Cell 2009
-
IRef Intact Interaction:
Complex of MUS81-SLX4-ERCC4
(physical association, anti tag coimmunoprecipitation)
Svendsen et al., Cell 2009
Text-mined interactions from Literome
Muñoz et al., Mol Cell 2009
:
Furthermore,
SLX4 enhances the nuclease activity of SLX1, MUS81, and
XPF
Kim et al., Blood 2013
(Fanconi Anemia) :
Here, by complementing a null FA-P Fanconi anemia cell line with SLX4 mutants that specifically lack the interaction with each of the nucleases, we show that the
SLX4 dependent
XPF-ERCC1 activity is essential for ICL repair but is dispensable for repairing TOP1 inhibitor induced DNA lesions