◀ Back to IL12A
IL12A — STAT1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Gollob et al., J Immunol 1999
:
A specific inhibitor of p38 MAP kinase completely inhibits the serine phosphorylation of
STAT1 and STAT3
induced by
IL-12 and IL-2 and abrogates the functional synergy between IL-12 and IL-2 without affecting STAT tyrosine phosphorylation
Gollob et al., J Immunol 2000
(Immunologic Deficiency Syndromes...) :
An examination of cytokine signaling revealed that STAT4 and extracellular regulated kinase 1 (ERK1) activation by IL-12 was intact, whereas the
activation of
STAT1 , -3, and -5 by
IL-12 was lost
Su et al., Biochem Biophys Res Commun 2001
:
IL-12 alone did not activate
STAT1 , but
IL-12 enhanced IFN-gamma mediated STAT1 phosphorylation in MC-38, MCA102, MCA205, MCA207 and Colon-26-NL-17 cells, which expressed IL-12 receptor beta1 mRNA
D'Cruz et al., Fertil Steril 2001
:
Tyrosine phosphorylation of
STAT 1 in capacitated sperm was enhanced by IFN-alpha and IFN-gamma, and that of STAT 4 was
enhanced by
IL-12
Sugawara et al., Tohoku J Exp Med 2004
(Genetic Predisposition to Disease...) :
Therefore,
STAT1 regulates
IL-12 expression and appears to be a critical transcription factor in controling mycobacterial infection
Flores et al., J Immunol 2007
:
Experiments performed with STAT-1 knockout mice demonstrated that the primary production of
IL-12 induced by CpG was
STAT-1 dependent , whereas the production of IL-10 was not
Zhang et al., Hum Immunol 2008
:
Also,
IL-12 augmented the expression of cytotoxic effector molecules, TRAIL and perforin, and the phosphorylation of
STAT1 , STAT4, and ERK1/2, which may also contribute to lysis by NK cells
Shanmugarajan et al., J Cell Biochem 2009
:
Chromatin immunoprecipitation ( ChIP ) assay confirmed STAT-3, but not
STAT-1 binding to the OIP-1 gene promoter in
response to
IL-12 stimulation
Smeekens et al., PloS one 2011
(Candidiasis, Chronic Mucocutaneous) :
Cloning and transfection experiments demonstrate that mutated
STAT1 inhibits
IL12R/IL-23R signaling, with hyperphosphorylation of STAT1 as the likely underlying molecular mechanism
Lecocq et al., J Immunol 2013
:
These data indicate that FcaRI ligation on human monocytes and dendritic cells
inhibits IL-12 expression and type 1 activation by interfering with
STAT1 activation
Yu et al., J Immunol 1996
:
STAT1 alpha
activation by
IL-12 correlated with increased phosphorylation of serine, but not tyrosine
Gollob et al., Blood 1998
:
To understand how the activation of these STATs contributes to T-cell IL-12 responsiveness, we analyzed the
IL-12 induced activation of STAT5 and
STAT1 in T cells stimulated to undergo Th1 or Th2 differentiation ... The
IL-12 induced tyrosine phosphorylation of STAT5 and
STAT1 , but not STAT4, is augmented in T cells activated into Th1 cells with PHA + interferon-gamma (IFN-gamma) compared with T cells activated with PHA alone
García et al., J Immunol 1998
:
Moreover, we showed that this increase in IFN-gamma could be explained by the dual
activation of
STAT1 and STAT4 by IL-15 and
IL-12 , respectively