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CSF1 — TNF
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Isaacs et al., J Cell Physiol 1999
:
Despite inhibition of NFkappaB signaling, NaS enhanced
TNFalpha stimulated
MCSF secretion and did not prevent TNFalpha stimulated increases in sMCSF mRNA, suggesting that NFkappaB was not involved in TNFalpha effect on the gene
Park et al., J Immunol 1999
:
Both the soluble form of CD40 ligand ( sCD40L ) and
TNF increased the level of
M-CSF and G-CSF mRNA
Besse et al., Biochim Biophys Acta 1999
:
By using a specific ELISA we found that their constitutive secretion of
M-CSF is
enhanced by
tumour necrosis factor-alpha (TNF-alpha) ... The lipid mediator prostaglandin E2 ( PGE2 ) markedly reduces in a time- and dose dependent manner the constitutive and
TNF-alpha induced
M-CSF synthesis by bone marrow stromal cells
Besse et al., Cytokine 2000
:
The anti-inflammatory molecules IL-10 and TGF-beta have no effect on the
TNF-alpha induced
M-CSF synthesis by marrow stromal cells
Yao et al., Endocrinology 2000
:
Nuclear factor-kappaB p50 is required for
tumor necrosis factor-alpha induced
colony stimulating factor-1 gene expression in osteoblasts ... We have reported that osteoblasts express
CSF-1 constitutively and that
tumor necrosis factor (TNF)-alpha , a potent bone resorbing agent,
increases CSF-1 gene expression by a transcriptional mechanism ... In the present study, we report that an NF-kappaB site in the CSF-1 promoter is required for
TNF-alpha induced
CSF-1 expression in osteoblasts ... To further confirm that p50 is necessary for
TNF-alpha induced
CSF-1 expression in osteoblasts, CSF-1 messenger RNA expression from untreated and TNF-alpha treated osteoblasts, prepared from wild-type and p50 knock-out mice, was examined by Northern analysis ... Our findings support the conclusion that the NF-kappaB subunit p50 is critical for
TNF induced
CSF-1 expression in osteoblasts
Gruber et al., J Immunol 1992
:
LPS and IL-1 beta, but not IL-6 or
TNF-alpha , dramatically
augmented the ability of anti-CD45, anti-CD44, and anti-LFA-3 antibodies to induce
M-CSF secretion but failed to stimulate M-CSF secretion in the absence of antibody
Brennan et al., Kidney Int 1992
(Lupus Nephritis) :
TNF alpha increased M-CSF secretion by stimulated MRL-lpr by twofold over unstimulated MRL-lpr MC, but did not
increase M-CSF in C3H MC
Nishina et al., Transplantation 2004
:
Electrophoretic mobility shift assay showed that
M-CSF induced inhibition of
TNF production was a result of suppression of nuclear factor-kappaB
Lavigne et al., Bone 2004
(Osteoarthritis...) :
PMMA and
TNF-alpha both
stimulated M-CSF and sRANKL production whereas PMMA decreased and TNF-alpha augmented OPG release by Ob
Kawano et al., Am J Reprod Immunol 2004
:
Our data indicated that
M-CSF and MCP-1 were
regulated by IL-1alpha and
TNF-alpha
Datta et al., Blood 1992
(Leukemia, Myelomonocytic, Acute) :
Pretreatment of THP-1 cells with pertussis toxin inhibited the increase in PKC activity but not the
induction of
TNF transcripts by
M-CSF
Dai et al., Ann Rheum Dis 2004
(Arthritis, Rheumatoid...) :
IL18, IL1 beta, and
TNF alpha did not
induce M-CSF , GM-CSF, IFN gamma, or OPG production in PHA prestimulated T cells or RA synovial T cells
Gruber et al., Cell Immunol 1992
:
Production of macrophage colony stimulating factor (
M-CSF ) by human monocytes is differentially
regulated by GM-CSF,
TNF alpha, and IFN-gamma ... Both
TNF alpha and IFN-gamma
enhanced M-CSF message levels induced by GM-CSF, but only TNF alpha synergized with GM-CSF in the induction of M-CSF protein secretion
Kitaura et al., J Clin Invest 2005
(Bone Resorption...) :
TNF-alpha stimulated
M-CSF gene expression, in vivo, only in the presence of TNF-responsive stromal cells
Yongchaitrakul et al., J Periodontol 2006
:
Because osteoclastogenesis requires the presence of macrophage colony stimulating factor ( M-CSF ), we examined whether HPDL cells secrete
M-CSF in
response to
tumor necrosis factor-alpha (TNF-alpha)
Kharbanda et al., Cancer Commun 1990
(Cell Transformation, Neoplastic...) :
Previous work suggested that
TNF induces
M-CSF gene expression through activation of phospholipase A2 and eicosanoid production
Zins et al., Cancer Res 2007
(Colonic Neoplasms) :
These results suggest that colon cancer cell derived TNF-alpha stimulates
TNF-alpha and CSF-1 production by macrophages, and that
CSF-1 , in turn,
induces macrophage VEGF-A and MMP-2 in an autocrine manner
Clinton et al., Am J Pathol 1992
(Arteriosclerosis) :
Bacterial lipopolysaccharide (LPS), recombinant human interleukin-1 alpha (IL-1 alpha) or
tumor necrosis factor alpha (TNF alpha) induced
MCSF mRNA accumulation in a concentration dependent manner in both EC and SMC
Hohensinner et al., Journal of thrombosis and haemostasis : JTH 2007
:
Only the NF-kappaB blocker dimethylfumarate and the dn IKK2, but not januskinase inhibitor-1 ( JNK-I ), were able to block the
TNF-alpha induced increase in
M-CSF production in these cells, suggesting that the induction of M-CSF through TNF-alpha is mainly dependent on the activation of the NF-kappaB pathway
Vallés et al., Biomaterials 2008
:
Experiments employing neutralising antibodies indicate that exposure of co-cultured macrophages to both Ti-based particles
induces the release of
M-CSF , GM-CSF, IL-6 and PGE2 through up-regulation of IL-1beta and
TNF-alpha
Yamada et al., Blood 1991
:
Previous studies have demonstrated that
tumor necrosis factor (TNF) induces transcription of the
M-CSF gene in human myeloid cells
Umezawa et al., Mol Cell Biol 1991
:
Cachectin/tumor necrosis factor transiently
induced the expression of
CSF-1 and inhibited the differentiation of H-1/A cells into adipocytes
Sherman et al., J Clin Invest 1990
(Leukemia, Promyelocytic, Acute) :
We also studied the signal transduction mechanisms responsible for regulating
TNF induced
CSF-1 mRNA levels ... Both 4-bromophenacyl bromide and quinacrine, inhibitors of phospholipase A2 activity, blocked
TNF induced increases in
CSF-1 transcripts in a concentration dependent manner, while caffeic acid and nordihydroguaiaretic acid, inhibitors of the 5-lipoxygenase pathway, had no detectable effect on induction of CSF-1 RNA ... These findings suggest that the increase in CSF-1 RNA observed during TNF treatment is regulated, at least in part, by both transcriptional and posttranscriptional mechanisms, and that PGE2 and cAMP regulate transcriptional
activation of the
CSF-1 gene by
TNF
Eda et al., Rheumatol Int 2011
(MAP Kinase Signaling System) :
On the other hand,
M-CSF mRNA expression level was significantly
induced by both IL-1ß and
TNF-a by up to 7- and 11-fold, respectively
Warren et al., J Immunol 1986
:
Macrophage growth factor
CSF-1 stimulates human monocyte production of interferon,
tumor necrosis factor , and colony stimulating activity
Shieh et al., J Immunol 1989
:
The reduction in
CSF-1 binding activity was reversed by prolonged incubation at 37 degrees C even in the
presence of
TNF
Peng et al., J Biol Chem 1995
:
The
induction of
M-CSF mRNA expression by either oxidized low density lipoprotein ( ox-LDL ) or
tumor necrosis factor-alpha (TNF alpha) was attenuated by NO donors, S-nitrosoglutathione ( GSNO ), sodium nitroprusside ( SNP ), and 3-morpholinosydnonimine, but not by cGMP analogues, glutathione, or nitrite
Aste-Amezaga et al., Cell Immunol 1994
:
It was found that IL-12 induces mRNA accumulation and production of GM-CSF and
TNF-alpha from both T and NK cells and, as tested on NK cells only,
induces M-CSF mRNA accumulation
Schook et al., J Leukoc Biol 1994
:
M-CSF and IL-10 strongly
inhibited TNF production at the level of both mRNA and bioactivity but had no effect on the production of IL-6
Campbell et al., Biochim Biophys Acta 1993
:
A specific radioimmunoassay was employed to demonstrate that human articular cartilage and chondrocyte monolayers in organ and cell culture, respectively, produce macrophage colony stimulating factor (
M-CSF ) in
response to stimulation with interleukin-1 alpha (IL-1 alpha), IL-1 beta,
tumor necrosis factor alpha (TNF alpha) and TNF beta ... Low levels of M-CSF were observed in the supernatants of nonstimulated cultures while increased levels of
M-CSF in
response to IL-1 alpha and
TNF alpha were detected following 2 h exposure to the cytokines ... We propose that chondrocyte
M-CSF production in
response to IL-1 and
TNF alpha , and the concurrent destruction of cartilage by these cytokines, could provide a mechanism for the chronic nature of rheumatoid disease
Kaplan et al., J Cell Physiol 1996
(Bone Resorption...) :
Tumor necrosis factor-alpha induces transcription of the
colony stimulating factor-1 gene in murine osteoblasts ... Because colony stimulating factor-1 (CSF-1) is essential for osteoclast progenitor proliferation, we examined the
effect of
TNF-alpha on osteoblast expression of
CSF-1 ... By Northern analysis,
TNF-alpha caused a dose and time ( 3 to 24 h ) dependent increase in
CSF-1 transcript expression in MC3T3-E1 cells ... mRNA stability studies using actinomycin D revealed that
TNF-alpha does not
affect CSF-1 mRNA half-life in MC3T3-E1 cells, while nuclear-run off analysis demonstrated that TNF-alpha increases
CSF-1 gene transcription ... Cycloheximide treatment of MC3T3-E1 cells up-regulated CSF-1 mRNA, and compared to either agent alone, cycloheximide and
TNF-alpha in combination
resulted in augmentation of
CSF-1 expression ... A series of studies using both agonists and inhibitors indicated that
TNF-alpha induced
CSF-1 expression did not involve the arachidonic acid, PKC, or cAMP pathways ... These results suggest that
TNF-alpha induces
CSF-1 expression in osteoblasts by a transcriptional mechanism which is largely independent of new protein synthesis and of the second messenger pathways examined
Held et al., J Interferon Cytokine Res 1996
:
These may caused by differences in the
M-CSF induced production of
TNF-alpha and IL-6
Kamanna et al., Biochim Biophys Acta 1996
:
In this study, we examined the
effect of
TNF-alpha on mesangial cell gene expression of
M-CSF , a colony stimulating factor associated with monocyte differentiation into macrophages and proliferation ... Incubation of mesangial cells with
TNF-alpha stimulated mRNA expression and protein synthesis of
M-CSF ... Stimulation of PKC depleted mesangial cells with either PMA or
TNF-alpha inhibited
M-CSF mRNA transcripts ... Preincubation of mesangial cells with calphostin C, a PKC inhibitor, reduced both PMA- and
TNF-alpha induced
M-CSF mRNA transcripts ... Specific protein tyrosine kinase inhibitors blocked
TNF-alpha induced mesangial cell
M-CSF mRNA expression ... However, coincubation of mesangial cells with TNF-alpha and either dbcAMP, forskolin, or pertussis toxin inhibited
TNF-alpha induced
M-CSF gene expression
Lajeunesse et al., J Clin Invest 1996
(Osteopetrosis) :
Osteopetrotic Ob-like cells obtained pre-BMT showed normal and abnormal 1,25 ( OH ) 2D3 induced alkaline phosphatase ( ALPase ) and osteocalcin production, respectively, and failed to produce macrophage colony stimulating factor (
M-CSF ) in
response to IL-1a and
TNF-alpha
Aubin et al., Kidney Int 1996
(Bone Neoplasms...) :
The production of macrophage colony stimulating factor (
M-CSF ) was stimulated in the
presence of 1,25 ( OH ) 2D3 ( 50 nM ),
TNF-alpha ( 2 ng/ml ) or both in MG-63 cells
Dybedal et al., Blood 1997
:
In the presence of
TNF , activation of Fas almost completely blocked clonogenic growth of lineage depleted ( Lin- ) bone marrow ( BM ) progenitor cells in
response to granulocyte-macrophage colony stimulating factor ( GM-CSF ),
CSF-1 , or a combination of multiple cytokines