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MSH4 — TNF

Text-mined interactions from Literome

Martínez-Esparza et al., Cell Mol Biol Incl Cyto Enzymol 1999 (Melanoma, Experimental) : Thus, tyrosinase activity and the rate of melanin formation in B16 melanocytes might reflect simply the balance between alpha-MSH stimulation and TGF beta1 or TNF alpha inhibition , acting by independent mechanisms
Catania et al., Ann N Y Acad Sci 1999 (Inflammation) : alpha-MSH reduces chemotaxis of human neutrophils and production of TNF-alpha , neopterin, and NO by monocytes
Huang et al., Neurosci Lett 2002 (Disease Models, Animal...) : This study 's objective was to determine whether the anti-inflammatory neuropeptide alpha-melanocyte stimulating hormone ( MSH ) can suppress postischemic activation of intracerebral tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) gene expression
Yoon et al., J Biol Chem 2003 : Here, we have investigated signaling pathways by which alpha-MSH inhibits lipopolysaccharide (LPS) induced TNF-alpha production in leukocytes such as THP-1 cells
Teare et al., Neuroreport 2004 (Inflammation) : alpha-MSH inhibited activation ( i.e. inhibited nuclear translocation ) in response to TNF-alpha or IFN-gamma by 81 % and 100 % respectively
Hill et al., Peptides 2006 : The present study confirms MC1R expression in cultured human dermal fibroblasts and reports that the MSH peptides alpha-MSH and KP ( -D- ) V inhibit TNF-alpha stimulated NF-kappaB activity and ICAM-1 upregulation, consistent with an anti-inflammatory role
Gatti et al., J Surg Res 2006 : Effects of ( CKPV ) 2, KPV, and [ Nle4-dPhe7 ] -alpha-MSH ( NDP-alpha-MSH ) on tumor necrosis factor alpha (TNF-alpha) production were determined : 1 ) in human peripheral blood mononuclear cells ( PBMC ) stimulated with lipopolysaccharide (LPS) in vitro, and 2 ) in rats injected with LPS i.v. and sacrificed at 1 h
Yamaoka-Tojo et al., Intern Med 2006 (Heart Failure) : alpha-MSH inhibited LPS induced TNF-alpha production, and alpha-MSH simultaneously augmented production of interleukin (IL)-10 by PBMC
Colombo et al., Shock 2007 (Inflammation...) : Bleomycin induced expression of proinflammatory and profibrotic factors ( interleukin 6, tumor necrosis factor-alpha , transforming growth factor-beta1, and inducible nitric oxide synthase ) and chemokines ( chemokine [C-C motif] ligand 2 and chemokine [C-C motif] ligand 5 ) was likewise significantly reduced by NDP-alpha-MSH
Lee et al., Am J Respir Cell Mol Biol 2011 : Real-time quantitative PCR data showed that a-MSH inhibited TNF-a induced expression of MUC5AC, and this effect of a-MSH was neutralized by knockdown of MC-1R using MC-1R shRNA lentivirus
Bitto et al., Br J Pharmacol 2011 (Multiple Organ Failure) : At day 7, in the liver and lung NDP-a-MSH, significantly reduced mRNA expression of tumour necrosis factor-a (TNF-a) , increased mRNA expression of interleukin-10 and improved the histological picture, as well as reduced TNF-a plasma levels ; furthermore, NDP-a-MSH dose-dependently increased survival rate, as assessed throughout the 16 day observation period
Minutoli et al., Endocrinology 2011 (Inflammation...) : NDP-a-MSH inhibited IL-6 and TNF-a expression, decreased histological damage, and increased neural efferent activity
Figueiredo et al., Naunyn Schmiedebergs Arch Pharmacol 2013 (Peritonitis) : NDP-MSH inhibited vascular leakage, leukocyte rolling, and adhesion and reduced peritoneal macrophage inflammatory protein 2, but not TNF-alpha , IL-1beta, IL-10, and keratinocyte derived chemokine production
Mason et al., J Immunol 1989 : The direct injection of MSH, beta-endorphin and ACTH into sponges or i.p. did not stimulate a neutrophil emigration and eliminated the possibility that MSH or ACTH suppressed the neutrophil influx in response to IL-1, TNF , or C5a by competing for circulating neutrophils
Delgado et al., J Leukoc Biol 1998 : We tested effects of alpha-MSH ( 1-13 ), alpha-MSH ( 11-13 ), and ACTH ( 1-24 ) on production of tumor necrosis factor alpha (TNF-alpha) , interleukin-6 (IL-6), and nitric oxide ( NO ) in a cultured murine microglial cell line ( N9 ) stimulated with lipopolysaccharide (LPS) plus interferon gamma (IFN-gamma)
Catania et al., Peptides 1998 (HIV Infections) : In separate experiments on normal peripheral blood mononuclear cells ( PBMC ), alpha-MSH ( 1-13 ) inhibited production of IL-1 beta and TNF alpha induced by HIV envelope glycoprotein gp 120
Lipton et al., Neuroimmunomodulation 1998 : To determine if microglia are involved in anti-inflammatory responses to alpha-MSH within the brain, murine cells were tested ; they produced TNF-alpha and nitric oxide in response to challenge, and production of both was reduced by alpha-MSH ... In tests on human astrocytes, both alpha-MSH ( 1-13 ) and alpha-MSH ( 11-13 ) reduced TNF-alpha