Gene interactions and pathways from curated databases and text-mining

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BMP10 — BMPR2

Pathways - manually collected, often from reviews:

  • BioCarta alk in cardiac myocytes: BMPR-II/ALK3 complex (BMPR2-BMPR1A) → BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4) (modification, collaborate)
  • BioCarta alk in cardiac myocytes: BMPR-II/ALK3 complex (BMPR2-BMPR1A) → BMP (BMP7/BMP2/BMP5/BMP10/BMP4) (modification, collaborate)
  • BioCarta alk in cardiac myocytes: BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4) → BMP (BMP7/BMP2/BMP5/BMP10/BMP4) (modification, collaborate)
  • BioCarta alk in cardiac myocytes: NOGGIN (NOG) → BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4) (modification, inhibits)
  • BioCarta alk in cardiac myocytes: BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4) → CHORDIN (CHRD) (modification, activates)

Text-mined interactions from Literome

Kano et al., Endocrinology 2005 : Furthermore, intracellular BMP signaling was markedly suppressed by dexamethasone treatment and the expression of ALK-2, ALK-3, and BMPRII was significantly inhibited by dexamethasone
Xia et al., J Biol Chem 2007 : In KGN human ovarian granulosa cells and mouse pulmonary artery smooth muscle cells, BMP2 and BMP4 signaling required BMP receptor type II (BMPRII) , but not activin receptor type IIA (ActRIIA) or ActRIIB, based on changes in BMP signaling by small interfering RNA inhibition of receptor expression
Wang et al., Biochem Biophys Res Commun 2008 : Moreover, while ATRA induced the expression of BMP-RIA , both BMP-RII and Smad5 mRNA were induced by OM and ATRA
Yang et al., Ann N Y Acad Sci 2010 (Bone Diseases, Developmental) : This study provides an in vivo tool to study the role of BMPRII in BMP/Smad signaling and the regulation of this pathway by PTH and Wnts
Gamer et al., Genesis 2011 : As BMP signaling is required for endochondral ossification and loss of either Acvr2a or Acvr2b is not associated with deficits in limb development, we hypothesized that BMPR-II would be essential for BMP signaling during skeletogenesis
Park et al., Dev Biol 2012 : The LIM kinase/cofilin pathway mediates non-canonical BMPRII induced de-epithelialization, in response to either cadherin-6B or BMP
Kim et al., Angiogenesis 2012 (Telangiectasia, Hereditary Hemorrhagic) : Conversely, BMP9 blocks EC sprouting and this is dependent on Alk1, BMPRII/ActRII and ID1/ID3