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BRAF — IL8

Text-mined interactions from Literome

Liang et al., Cancer Res 2007 (Lung Neoplasms...) : Mechanistic studies showed that inhibition of ( V600E ) B-Raf significantly reduced the constitutive secretion of IL-8 from melanoma cells as well as the capacity of endogenous IL-8 production from the melanoma-PMN microenvironment
Crawford et al., Mol Cancer Ther 2008 (Melanoma) : A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker
Knall et al., J Biol Chem 1996 : Surprisingly, wortmannin, at low concentrations, inhibits Raf-1, B-Raf , and MAPK activation in response to IL-8 and C5a demonstrating a role for phosphatidylinositol 3-kinase in the activation of Raf kinases in G protein coupled receptor systems in human neutrophils