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NOTCH1 — VEGFA

Text-mined interactions from Literome

Liu et al., Mol Cell Biol 2003 : Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells : implications for modulating arteriogenesis and angiogenesis ... We show here that vascular endothelial growth factor ( VEGF ) but not basic fibroblast growth factor can induce gene expression of Notch1 and its ligand, Delta-like 4 (Dll4), in human arterial endothelial cells
Wang et al., Cancer Res 2006 (Neoplasm Invasiveness...) : Because NF-kappaB, VEGF, and MMPs are critically involved in the processes of tumor cell invasion and metastasis, we investigated the role and mechanism ( s ) by which Notch-1 down-regulation ( using molecular approaches ) may lead to the down-regulation of NF-kappaB, vascular endothelial growth factor ( VEGF ), and MMP-9, thereby inhibiting invasion of pancreatic cancer cells through Matrigel ... Consistent with these results, we found that the down-regulation of Notch-1 reduced NF-kappaB DNA binding activity and VEGF expression
Ii et al., Circulation 2010 (Atherosclerosis...) : Cholesterol enhanced the messenger RNA expression ( quantitative, real-time reverse-transcription polymerase chain reaction ) of vascular endothelial growth factor and inhibited Notch1 messenger RNA expression in both ApoE ( -/- ) and WT EPCs, whereas endothelial nitric oxide synthase messenger RNA expression increased in ApoE ( -/- ) EPCs and declined in WT EPCs after cholesterol exposure
Kume et al., Histol Histopathol 2010 : For arterial specification, vascular endothelial growth factor ( VEGF ) induces expression of Notch signaling genes, including Notch1 and its ligand, Delta-like 4 (Dll4), and Foxc1 and Foxc2 transcription factors directly regulate Dll4 expression
Kiec-Wilk et al., J Physiol Pharmacol 2010 : The MAPK dependent regulation of the Jagged/Notch gene expression by VEGF , bFGF or PPAR gamma mediated angiogenesis in HUVEC
Lin et al., Diabetes 2010 (Diabetic Nephropathies) : Our findings suggest that upregulation of Notch-1 signaling in HG-treated renal podocytes induces VEGF expression and subsequent nephrin repression and apoptosis
Funahashi et al., Vascular cell 2011 : Expression of a secreted Notch antagonist ( Notch1 decoy ) suppressed VEGF mediated activation of endothelial Notch signaling and endothelial morphogenesis
Lucitti et al., Circ Res 2012 : Endothelial-specific reduction of a disintegrin-and-metalloprotease-domain-10 (Adam10) and inhibition of ?-secretase increased collateral formation, consistent with their roles in VEGF induced Notch1 activation and suppression of prosprouting signals
Guo et al., Neoplasma 2013 (Multiple Myeloma...) : Notch1 overexpression in MM cells resulted in up-regulation of VEGF expression, promotion of tumor growth, and increased microvessel density (MVD)
Gao et al., Ann Rheum Dis 2013 (Arthritis, Psoriatic...) : Here, we examine whether Notch signalling mediates vascular endothelial growth factor ( VEGF ) and angiopoietin 2 (Ang2) induced vascular function ... VEGF and Ang2 induced Notch-1 IC/ Notch-4 IC protein expression in synovial explant cultures and human microvascular EC levels were further potentiated by VEGF/Ang2 stimulation in combination ... Notch-1 , Delta-like-ligand 4, and Hrt-2 mRNA expression were significantly induced by VEGF and Ang2 alone and in combination