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NA — TNF

Text-mined interactions from Literome

Gosset et al., Eur Respir J 1999 : Since exogenous as well as endogenous thiols could be potent inhibitors of the production of cytokines, the effects of N-acetylcysteine (NAC) , glutathione ( GSH ) and modulated GSH synthesis on the production of tumour necrosis factor (TNF)-alpha , interleukin (IL)-6 and IL-8 by human alveolar macrophages ( AMs ) was evaluated, as well as the potential role of intracellular GSH depletion on the effect of exogenous thiols ... Similarly, NAC inhibited the production of TNF-alpha , IL-6 and IL-8 in GSH depleted AMs obtained by BSO pretreatment
De la Fuente et al., Free radical research 2001 (Shock, Septic) : Adherence to tissues and chemotaxis ( the earliest two functions of lymphocytes in the immune response ), as well as ROS levels and TNF alpha production were determined in the presence or absence of NAC or AA ( 0.001, 0.01, 0.1, 1 and 2.5 mM ) in lymphocytes from peritoneum, axillary nodes, spleen and thymus obtained at several times ( 2, 4, 12 and 24 hours ) after LPS injection
Lean et al., J Clin Invest 2003 (Bone Resorption) : Expression of TNF-alpha , a target for NF-kappaB and a cytokine strongly implicated in estrogen-deficiency bone loss, was suppressed in osteoclasts by 17-beta estradiol and NAC
Peristeris et al., Cell Immunol 1992 : In this study we investigated the effect of NAC on TNF production and LPS lethality in mice
Ramudo et al., J Pathol 2005 (Acute Disease...) : In addition, NAC delayed monocyte TNF-alpha production, thereby maintaining low TNF-alpha levels in plasma during BPDO
Kao et al., Clin Exp Pharmacol Physiol 2006 (Body Weight...) : In addition, NAC diminished the LPS induced increases in nitrate/nitrite, MG, TNF-a and IL-1b
Sury et al., Free Radic Biol Med 2006 (MAP Kinase Signaling System) : Intriguingly, NAC had no effect on the initial activation ( i.e., IkappaB degradation, nuclear p65 translocation, and Ser536 phosphorylation ) of NF-kappaB by TNF-alpha
Jin et al., Hepatobiliary Pancreat Dis Int 2007 (Reperfusion Injury) : NAC inhibited the activation of TLR2/4 and the induction of TNF-alpha resulting from I/R injury via modulating the redox state, thus it may mitigate liver and lung injury following partial hepatic I/R in mice
Wu et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2007 (Disease Models, Animal...) : NAC can inhibit the activation of TLR2/4 and the induction of TNF-alpha resulted from I/R injury via modulating the state of redox process ; thus it might mitigate liver and lung injury following partial hepatic I/R in mice
Hu et al., J Toxicol Environ Health 2007 : The secretion of IL-1beta and TNF-alpha by silica exposed AM was markedly inhibited by NAC and R6G, suggesting that the production of these cytokines is also ROS dependent
Demiralay et al., Hum Exp Toxicol 2007 : NAC and vitamin E significantly reduced the increases in the local production of TNF-alpha and VEGF, and perivascular MPO activity
Eberlein et al., Journal of inflammation (London, England) 2008 : NAC and DMSO inhibit HA fragment induced expression of TNF-alpha and KC protein in alveolar and peritoneal macrophages
Yubero et al., Crit Care Med 2009 (Pancreatitis, Acute Necrotizing) : Dx, administered before or after AP, and NAC reduced the leukocytosis induced by AP and blocked the ability of circulating monocytes to produce tumor necrosis factor-alpha and monocyte chemoattractant protein-1 ; however none of them significantly reduced the overexpression of intercellular cell adhesion molecule-1 found in monocytes 6 hrs after inducing AP. Leukocyte infiltration in the pancreas was attenuated in Dx-pretreated rats and significantly reduced 6 hrs after inducing AP in rats treated with NAC
Wu et al., Free Radic Biol Med 2009 (MAP Kinase Signaling System) : Activation of JNK and p38MAPK was weaker in TNFalpha plus PY-treated NOS2 ( -/- ) mice and 1400W and NAC blocked the activation of JNK and p38MAPK in wild-type mice
Xu et al., Acta Pharmacol Sin 2009 (Disease Models, Animal...) : NAC treatment also decreased the pulmonary protein content at 48 and 72 h and the lung wet/dry weight ratio at 24 and 48 h. Additionally, NAC enhanced pulmonary production of TNF-alpha and IL-10 at 24 h and 48 h
Zhang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010 : To explore the effect of N-acetylcysteine ( NAC ) on the interleukin(IL)18 induced expression of tumor necrosis factor (TNF) alpha and interleukin(IL) 6 in mouse vascular smooth muscle cells ( VSMC ) ... NAC inhibited the mRNA expression and protein secretion of TNF-alpha and IL-6 induced by IL-18 ( P > 0.01 )
Roederer et al., Proc Natl Acad Sci U S A 1990 : NAC , which replenishes intracellular glutathione, effectively inhibits the tumor necrosis factor alpha- or phorbol ester stimulated replication of HIV in acutely infected cell cultures
Chae et al., Mol Cells 2011 (Anoxia...) : The results from immunohistochemical staining demonstrated that NAC suppressed the expression of IL-1ß and TNF-a in the periodontal ligament tissues compared to the vehicle treated group
Lima Trajano et al., Inhal Toxicol 2011 (Acute Lung Injury...) : NAC also inhibited the transcription of NF?B, IL-6, TNF-a and COX2 usually induced by LPS
de Senzi Moraes Pinto et al., Clin Nutr 2013 : NAC reduced TNF-a and 4-HNE-protein adducts levels, inflammation, creatine kinase levels, and myonecrosis in diaphragm muscle
Koo et al., Cell Biol Int 2013 : TNF-a increased tyrosine phosphorylation of Syk, which was attenuated by NAC and MPA
Michailidis et al., Am J Clin Nutr 2013 (Inflammation) : NAC also abolished the increase in myogenic determination factor and reduced tumor necrosis factor-a 8 d after exercise
Zhang et al., J Int Med Res 2013 (Inflammation...) : NAC attenuated silica induced increases in TNF-a , IL-8 and hsCRP in BALF and serum
Gatti et al., Clin Exp Immunol 1993 (Disease Models, Animal...) : NAC also blocked TNF production in blood and in bronchoalveolar lavage
Delneste et al., Blood 1997 (Leukemia L1210) : Our data show that NAC ( 1 ) induces an early and sustained increase of membrane tumor necrosis factor alpha (TNF alpha) expression on human stimulated-peripheral blood (PB) T cells and ( 2 ) increases membrane TNF-RI and TNF-RII on tumoral cell lines and on T cells after stimulation
Pahan et al., Free Radic Biol Med 1998 : Besides NO, NAC also blocked the production of TNF-alpha in rat peritoneal macrophages activated with endotoxin
Bellezzo et al., J Lab Clin Med 1998 (Liver Diseases) : NAC and alpha-TOC also markedly suppressed LPS induced tumor necrosis factor-alpha (TNF-alpha) mRNA levels and secretion
Kawada et al., Hepatology 1998 : On the other hand, kinetic analysis showed that production of nitric oxide ( NO ) and tumor necrosis factor alpha (TNF-alpha) by lipopolysaccharide stimulated Kupffer cells was strongly inhibited by resveratrol and quercetin but not by NAC
Hultén et al., Transplantation 1998 : The effects of BHT and NAC on TNF-alpha production were studied both with and without lipopolysaccharide (LPS) activation of alveolar macrophages from bronchoalveolar lavage fluid
Tsuji et al., Clin Exp Immunol 1999 (Arthritis, Experimental) : Bucillamine and NAC inhibited NF-kappaB activation and tumour necrosis factor-alpha (TNF-alpha) mRNA expression in human monocytic leukaemia cell line THP-1, and cytokine production from monocyte cell lines at concentrations > 10-3 M