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PLA2G4A — TNF

Text-mined interactions from Literome

Pirianov et al., Cell Death Differ 1999 : As assessed by [ 3H ] -arachidonic acid release, cells primed for 48 h with CB1093 ( 50 nM ) showed enhanced cPLA2 activation in response to TNFalpha or ceramide
Kuebler et al., J Clin Invest 2000 (Vasculitis) : Alveolar TNF-alpha increased [ Ca ( 2+ ) ] ( i ) and activated cPLA(2) in alveolar epithelial cells, and increased both endothelial [ Ca ( 2+ ) ] ( i ) and P-selectin expression in adjoining perialveolar capillaries
Lüschen et al., Biochem Biophys Res Commun 2000 : Activation of ERK1/2 and cPLA(2) by the p55 TNF receptor occurs independently of FAN ... Analysis of embryonal fibroblasts from FAN knockout mice revealed that TNF induced activation of both ERK and cPLA(2) occurs without involvement of FAN ... Furthermore, we provide evidence that the TNF dependent activation of ERK and cPLA(2) requires the intact death domain of TNF-R55 ... Finally, we demonstrate that in murine fibroblasts cPLA(2) is phosphorylated in response to TNF solely by ERK, but not by p38 mitogen activated protein kinase, suggesting a signaling pathway from TNF-R55 via the death domain to ERK and cPLA(2)
El Mahdani et al., J Immunol 2000 : Western blot analysis revealed that TNF induced a differential cleavage of cPLA(2) in TNF-sensitive vs TNF-resistant cells
Wu et al., Br J Haematol 2000 (Acute Disease...) : In this study, we found that Dex inhibited both spontaneous and TNF induced activation of cPLA(2)
Awasthi et al., Am J Physiol Lung Cell Mol Physiol 2001 : We found that in H441 cells, as reported in other cell types, cytosolic phospholipase A2 (cPLA2) is activated by TNF-alpha
Krönke et al., FEBS Lett 2002 (Inflammation) : Role of caspases in TNF mediated regulation of cPLA(2)
Jiang et al., Mol Cell Biochem 2003 : In this study, the effect of phorbol 12-myristate 13-acetate ( PMA ), tumor necrosis factor alpha (TNFalpha), lipopolysaccharide (LPS) and macrophage-colony stimulating factor ( M-CSF ) on AA release and prostaglandin E2 ( PGE2 ) production and the expression of cPLA2 and COX-1 and -2 were investigated in U937 human pre-monocytic cells and fully differentiated macrophages
Shimizu et al., J Pharmacol Sci 2004 : However, the signaling pathway by which TNFalpha activates cPLA2alpha remained to be solved
Culver et al., Life Sci 2005 (Calcium Signaling) : On the other hand, NDGA did not interfere with the TNF induced phosphorylation of cPLA(2) , indicating that NDGA does not block all TNF dependent signaling
Oikawa et al., FEBS Lett 2005 (Diabetes Mellitus, Type 1) : In their macrophages, decreased prostaglandin E ( 2 ) ( PGE ( 2 ) ) induced by cPLA(2)alpha deficiency, and the increase in production of tumor necrosis factor (TNF)-alpha were observed
Chenevier-Gobeaux et al., Life Sci 2007 (Arthritis, Rheumatoid...) : Basal PLA(2) activity was significantly more important in RA cells than in OA cells ; PLA(2) activity was increased in IL-1beta and TNF-alpha pre treated RA cells, and cPLA(2) inhibitors inhibited this activity
Barakat et al., Naunyn Schmiedebergs Arch Pharmacol 2009 (Brain Ischemia...) : Furthermore, OGD and the NF-kappaB activator tumor necrosis factor stimulated the expression of cPLA-2 , cyclooxygenase-2 (COX-2), and mPGES-1 and increased the release of PGE ( 2 ) from neurons
Bryant et al., J Biol Chem 2011 (Arthritis, Rheumatoid) : Selective cytosolic phospholipase A ( 2 ) -a ( cPLA(2)-a ) inhibitors abrogate TNF/sPLA ( 2 ) -IIA mediated PGE ( 2 ) production without affecting COX-2 levels, indicating arachidonic acid ( AA ) flux to COX-2 occurs exclusively through TNF mediated activation of cPLA(2)-a
Lee et al., J Cell Physiol 2011 : However, the mechanisms underlying TNF-a induced cPLA(2) expression and PGE ( 2 ) synthesis in human tracheal smooth muscle cells ( HTSMCs ) remain unknown ... TNF-a induced cPLA(2) expression was also inhibited by pretreatment with a selective NF-?B inhibitor [ helenalin ( HLN ) ] or transfection with dominant negative mutants of NF-?B inducing kinase ( NIK ) or I?B kinase ( IKK ) a/ß. TNF-a induced NF-?B translocation was blocked by pretreatment with NAC, DPI, APO, or HLN, but not by U0126, SB202190, or SP600125 ... These results suggested that in HTSMCs, activation of p47(phox), MAPKs, NF-?B, and p300 is essential for TNF-a induced cPLA(2) expression and PGE ( 2 ) release
Saito et al., Am J Physiol Heart Circ Physiol 2012 (Myocardial Infarction...) : H/R and TNF-a induced cPLA(2)a phosphorylation in cPLA(2)a ( +/+ ) cardiomyocytes, which was reversible by sTNFR : Fc
Waterman et al., Biochem Biophys Res Commun 1995 : We demonstrate that TNF-alpha stimulation of neutrophils induces the phosphorylation of cytosolic phospholipase A2 (cPLA2) and also increases its activity
Wold et al., J Cell Biochem 1993 : The E3 14.7K and 10.4K/14.5K proteins inhibit TNF activation of cytosolic phospholipase A2 (cPLA2) , which may explain how they inhibit TNF cytolysis
Hoeck et al., Proc Natl Acad Sci U S A 1993 : By itself, TNF causes a modest increase in cPLA2 activity, but with the Ca2+ ionophore A23187 it provides a strong synergistic action
Wu et al., Biochim Biophys Acta 1996 : These results demonstrate that the cPLA2 gene expression is up-regulated by TNF-alpha and this effect may contribute to the TNF-alpha stimulated AA release in airway epithelial cells
Kawaguchi et al., J Bone Miner Res 1996 (Bone Resorption) : We conclude that ( 1 ) IL-1, TNF-alpha , and PTH, but not IL-6 nor IL-11, can increase the expression of PGHS-2, cPLA2 , and PGE2 production in cultured mouse calvariae ; ( 2 ) IL-4 inhibits PGE2 production in both control and stimulated calvarial cultures by inhibiting PGHS-2 and cPLA2 ; and ( 3 ) IL-4 has an inhibitory effect on bone resorption which is independent of PG production
Dimitrov et al., J Virol 1997 : We now report that TNF induces translocation of cPLA2 from the cytosol to membranes in Ad-infected human A549 cells and that E3-10.4K/14.5K but not E3-14.7K or E1B-19K is required to inhibit TNF induced translocation of cPLA2 ... We propose that E3-10.4K/14.5K inhibits TNF induced AA release and apoptosis by directly or indirectly inhibiting TNF induced translocation of cPLA2 from the cytosol to membranes
Wissing et al., Proc Natl Acad Sci U S A 1997 (Breast Neoplasms...) : We report here that TNF induced activation of caspases results in the cleavage and activation of cytosolic phospholipase A2 (cPLA2) and that activated cPLA2 contributes to apoptosis ... Inhibition of caspases by expression of a cowpox virus derived inhibitor, CrmA, or by a specific tetrapeptide inhibitor of CPP32/caspase-3, acetyl-Asp-Glu-Val-Asp-aldehyde ( Ac-DEVD-CHO ), inhibited TNF induced activation of cPLA2 and apoptosis ... TNF induced activation of cPLA2 was accompanied by a cleavage of the 100-kDa cPLA2 to a 70-kDa proteolytic fragment
Wu et al., Cancer Res 1998 (Leukemia) : Both immunofluorescence microscopy and Western blotting of cell subcompartments demonstrated translocation of cPLA2 from the cytosol to the cell membrane in response to TNF ... Prior incubation of cells with 1,25 ( OH ) 2D3 significantly inhibited ( a ) TNF induced [ 3H ] arachidonic acid release and apoptosis, ( b ) TNF induced translocation of cPLA2 to the membrane, and ( c ) the up-regulation of cPLA2 mRNA with TNF ... 1,25 ( OH ) 2D3 directly inhibits cPLA2 translocation and mRNA up-regulation induced by TNF
Pruzanski et al., Biochim Biophys Acta 1998 : IL-1/TNF and growth factors had no significant effect on cPLA2 mRNA expression
Wu et al., J Immunol 1998 (Leukemia) : Activation of cytosolic phospholipase A2 (cPLA2) by TNF has been shown to be an important component of the signaling pathway leading to cell death ... TNF could activate cPLA2 only in U937 and HL60 TNF-sensitive leukemic cells, but not in KG1a, CEM, and CEM/VLB100 cells that are relatively resistant to TNF ... The protein synthesis inhibitor, cycloheximide, increased TNF induced cPLA2 activity and cytotoxicity in both CEM and CEM/VLB100 cell lines
O'Brien et al., J Immunol 1998 (Adenoviridae Infections) : Our experiments show that TNF and CHI, when used independently, caused the rapid phosphorylation of cPLA2 ( within 10 min )
Thommesen et al., J Immunol 1998 : The trifluoromethyl ketone analogue of eicosapentaenoic acid ( EPACOCF3 ) also suppressed TNF induced NF-kappaB activation and inhibited in vitro cPLA2 enzyme activity with a similar potency as AACOCF3
De Valck et al., J Cell Biochem 1998 (Necrosis) : Moreover, a comparative study using TNF and anti-Fas antibodies as cell death stimuli showed that PLD and cPLA2 are specifically activated by TNF