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PDGFB — SMAD3

Text-mined interactions from Literome

Saika et al., Lab Invest 2004 (Disease Models, Animal...) : Our data show that induction of PDGF-BB by Smad3 dependent TGF-beta signaling is likely an important secondary proliferative component of the disease process
Jinnin et al., Mol Pharmacol 2006 (Scleroderma, Systemic) : Immunoprecipitation revealed that SIS3 attenuated the transforming growth factor (TGF)-beta1 induced phosphorylation of Smad3 and interaction of Smad3 with Smad4 ... Moreover, we demonstrated that SIS3 completely diminished the constitutive phosphorylation of Smad3 as well as the up-regulated type I collagen expression in scleroderma fibroblasts
Li et al., Diabetes 2010 (Diabetes Mellitus, Experimental...) : Immunoprecipitation/Western blotting showed that Smad3 was activated by AGEs but was inhibited by SIS3 in MMECs and in STZ induced diabetic nephropathy
Kim et al., Cancer Lett 2012 (Breast Neoplasms) : In addition, EGF induced MMP-9 expression was inhibited by UO126 ( a MEK1/2 inhibitor ) or SIS3 ( a smad3 inhibitor ), but not by SP600125 ( a JNK inhibitor )
Inoue et al., Lab Invest 2012 (Fibrosis...) : Both OCT and SIS3 , a Smad3 inhibitor , abrogated the binding of pSmad3 to the promoter and consequently attenuated the autoinduction