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Cantor et al., Int J Cancer 2007
(Carcinoma, Non-Small-Cell Lung...) :
Responding tumors showed restoration of Fhit , Wwox, p16 ( INKa ), Rassf1a expression, low mitotic activity, high apoptotic fraction and activation of caspase 3
Zhang et al., Int Immunol 2009
:
It was previously shown that ectopic expression of Nit1 or Fhit led to caspase activation and apoptosis, and that both proteins may play a role in DNA damage induced apoptosis