Dasgupta et al., Cancer Res 2005
(Astrocytoma...) :
Recent studies from our laboratory have shown that neurofibromin also regulates the mammalian target of rapamycin activity in a Ras dependent fashion, and that the rapamycin mediated mammalian target of rapamycin inhibition ameliorates the Nf1-/- astrocyte growth advantage
Hegedus et al., Cancer Res 2008
(Disease Models, Animal...) :
Because neurofibromin negatively regulates mammalian target of rapamycin (mTOR) signaling , we showed that pharmacologic mTOR inhibition in vivo led to decreased tumor cell proliferation in a dose dependent fashion associated with a decrease in tumor volume ... Because neurofibromin negatively regulates mammalian target of rapamycin (mTOR) signaling, we showed that pharmacologic mTOR inhibition in vivo led to decreased tumor cell proliferation in a dose dependent fashion associated with a decrease in tumor volume
Banerjee et al., Cancer Res 2010
:
The NF1 gene product neurofibromin negatively regulates Ras and mammalian target of rapamycin (mTOR) signaling , prompting clinical trials to evaluate the ability of Ras and mTOR pathway inhibitors to arrest NF1 associated tumor growth