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PIK3R1 — PLAU

Text-mined interactions from Literome

Kusch et al., J Biol Chem 2000 : We demonstrate that uPA induces PI3-K activation, which is abolished in VSMC expressing the dominant negative form of Tyk2 ... The regulatory subunit p85 of PI3-K co-immunoprecipitates with Tyk2 but not with Jak1, Jak2, or Jak3, and uPA stimulation increases the PI3-K activity in Tyk2 immunoprecipitates ... We provide evidence that the Tyk2 mediated PI3-K activation in response to uPA is required for VSMC migration
Chandrasekar et al., Oncogene 2003 (Central Nervous System Neoplasms...) : Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells
Sliva et al., Curr Cancer Drug Targets 2004 (Neoplasm Invasiveness...) : The inhibition of PKC and PI3K signaling ( through NF-kappaB and AP-1 ) suppressed the secretion of uPA , resulting in the inhibition of motility of highly invasive breast cancer cells
Nicholl et al., J Vasc Surg 2005 : uPA activation of PI3K and MKK3/6 was EGFR dependent and that of MEK1 was EGFR independent
Poettler et al., Thromb Haemost 2012 : Thus, VEGF165, VEGF-E, FGF-2, EGF as well as HGF induced a PI3k dependent activation of pro-uPA when bound to uPAR, which led to an increase in cell surface fibrinolytic activity