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Hoshiya et al., J Biol Chem 2003
(Breast Neoplasms) :
MIS induced IRF-1 expression in the mammary glands of mice in vivo and in breast cancer cells in vitro and stimulation of IRF-1 by MIS was dependent on activation of the NF kappa B pathway
Gupta et al., Cancer Res 2007
(Breast Neoplasms) :
Mullerian inhibiting substance (MIS) , a transforming growth factor-beta family member, activates the nuclear factor-kappaB (NF-kappaB) pathway and induces the expression of B-cell translocation gene 2 (BTG2), IFN regulatory factor-1 (IRF-1) , and the chemokine Gro-beta ... However, induction of IRF-1 and BTG2 mRNAs by MIS was independent of Smad1 activation