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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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ECM1 — IL18

Text-mined interactions from Literome

Zhang et al., Leuk Res 2004 (Leukemia, Myeloid...) : In the ECM invasion assay IL-18 significantly up-regulated transmigration of HL-60 cells, which in turn was inhibited by a synthetic MMP inhibitor : O-phenanthroline ( o-PE ), anti-MMP-9, anti-MMP-2 as well as anti-IL-18 monoclonal antibody ( McAb ), respectively, suggesting that induction of gelatinases by IL-18 leads to ECM degradation by these cells
Yeh et al., J Cell Physiol 2012 (Glioma) : Here, we found that C6 glioma -- but not primary astrocyte derived extracellular matrix ( ECM ) could activate microglia, including primary microglia and BV-2 cell line, and activated microglia secreted interleukin (IL)-18 , a potent inflammatory cytokine of the IL-1 family, to promote C6 migration ... Taken together, these results indicate that IL-18 secreted by microglia, which was activated by C6 glioma derived ECM , enhanced migration of C6 glioma through NO/cGMP pathway
Sarkissian et al., J Rheumatol 1998 (Arthritis, Rheumatoid...) : Transforming growth factor-beta ( TGF-beta ) or platelet derived growth factor ( PDGF ), but not interleukin 1 or exogenous fibronectin, induced ECM fibronectin