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MSH6 — PMS2

Pathways - manually collected, often from reviews:

• Reactome Reaction: MSH6 → PMS2 (reaction) Clark et al., J Biol Chem 2000*, Kleczkowska et al., Genes Dev 2001, Blackwell et al., J Biol Chem 2001*, Plotz et al., Nucleic Acids Res 2002*, Zhang et al., Cell 2005, Constantin et al., J Biol Chem 2005, Kadyrov et al., Cell 2006, Masih et al., Nucleic Acids Res 2008*, Iyer et al., J Biol Chem 2008*, Iyer et al., J Biol Chem 2010, Pluciennik et al., Proc Natl Acad Sci U S A 2010, Hombauer et al., Cell 2011
• Reactome Reaction: MSH6 → PMS2 (indirect_complex) Clark et al., J Biol Chem 2000*, Kleczkowska et al., Genes Dev 2001, Blackwell et al., J Biol Chem 2001*, Plotz et al., Nucleic Acids Res 2002*, Nielsen et al., Oncogene 2004, Zhang et al., Cell 2005, Constantin et al., J Biol Chem 2005, Kadyrov et al., Cell 2006, Knudsen et al., Nucleic Acids Res 2007, Masih et al., Nucleic Acids Res 2008*, Iyer et al., J Biol Chem 2008*, Iyer et al., J Biol Chem 2010, Pluciennik et al., Proc Natl Acad Sci U S A 2010, Liberti et al., DNA repair 2011, Hombauer et al., Cell 2011

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PMS2 — MSH6 (physical association, affinity chromatography technology) Plotz et al., Nucleic Acids Res 2003*
• IRef Biogrid Interaction: PMS2 — MSH6 (physical association, affinity chromatography technology) Matton et al., J Biol Chem 2000*
• IRef Biogrid Interaction: PMS2 — MSH6 (physical association, affinity chromatography technology) Cannavo et al., J Biol Chem 2007
• MIPS CORUM MSH2-MSH6-PMS2-MLH1 complex: MSH2-MSH6-PMS2-MLH1 complex complex (MLH1-MSH2-MSH6-PMS2) Matton et al., J Biol Chem 2000*
• MIPS CORUM PCNA-MutS-alpha-MutL-alpha-DNA complex: PCNA-MutS-alpha-MutL-alpha-DNA complex complex (MLH1-MSH2-MSH6-PCNA-PMS2) Hidaka et al., Nucleic Acids Res 2005*
• MIPS CORUM MSH2-MSH6-PMS2-MLH1 complex: MSH2-MSH6-PMS2-MLH1 complex complex (MLH1-MSH2-MSH6-PMS2) Blackwell et al., J Biol Chem 2001*
• IRef Corum Interaction: Complex of 11 proteins (association, protein cross-linking with a bifunctional reagent) Hidaka et al., Nucleic Acids Res 2005*
• IRef Corum Interaction: Complex of 13 proteins (association, surface plasmon resonance) Blackwell et al., J Biol Chem 2001*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Plotz et al., Nucleic Acids Res 2003*

Text-mined interactions from Literome

Hidaka et al., Nucleic Acids Res 2005 : PCNA-MutSalpha mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells
Sacho et al., Mol Cell 2008 : It has been suggested that conformational changes, modulated by adenine nucleotides, mediate the interactions of MutL alpha with other proteins in the MMR pathway, coordinating the recognition of DNA mismatches by MutS alpha and the activation of MutL alpha with the downstream events that lead to repair