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IDO1 — PTGS2
Text-mined interactions from Literome
Lee et al., J Immunother 2009
(Lung Neoplasms) :
It was recently shown that maturation of dendritic cells in the presence of indoleamine 2, 3-dioxygenase ( IDO ) results in activation of Tregs, and inhibition of
COX-2 activity
regulated IDO expression within the tumor microenvironment
Zhang et al., Ann Surg Oncol 2011
(Colorectal Neoplasms) :
Here, we analyzed the effect of indomethacin (
Indo , a nonselective
COX-2 inhibitor ) and nimesulide ( Nim, a selective COX-2 inhibitor ) on mTOR signaling in CRC cells in vitro and in vivo to determine the dependence of this effect on COX-2
Mei et al., Mol Hum Reprod 2012
(Endometriosis) :
Inhibition of
IDO1 by L-1-MT
suppressed the expression of
COX-2 and MMP-9 in ESCs
Obermajer et al., Transplantation research 2012
:
We observed that PGE2 induces endogenous cyclooxygenase
(COX)2 expression in cultured monocytes, blocking their differentiation into CD1a+ dendritic cells (DCs) and
inducing the expression of
indoleamine 2,3-dioxygenase 1 , IL-4Ra, nitric oxide synthase 2 and IL-10 - typical MDSC associated suppressive factors
Spatz et al., Am J Physiol 1994
:
Dexamethasone ( Dxm ),
indomethacin (Indo) , and nordihydroguaiaretic acid, the respective
inhibitors of
PLA2-cyclooxygenase II , cyclooxygenase, and lipoxygenase, increased both constitutive and AVP- or ANG II-stimulated secretion of ET-1