Gene interactions and pathways from curated databases and text-mining

◀ Back to RCOR1

HDAC2 — RCOR1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Koipally et al., J Biol Chem 2000 : These data strongly suggest that CtBP contributes to a histone deacetylase activity independent mechanism of repression by Ikaros
Brunori et al., J Virol 2001 (Neoplasms) : Tcf4 is constitutively activated by mutations in the adenomatous polyposis coli and beta-catenin genes in virtually all colon tumors and is constitutively repressed by Groucho and CtBP in normal tissue
Izutsu et al., Blood 2001 (Cell Transformation, Neoplastic...) : The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling
Vo et al., Mol Cell Biol 2001 : In this study, we show that the interaction between CtBP and the nuclear hormone receptor corepressor RIP140 is regulated similarly, in this case by p300/CBP itself
Ballas et al., Neuron 2001 : In the presence of REST , the CoREST/HDAC2 complex occupied the native Nav1.2 sodium channel gene in chromatin
Izutsu et al., Oncogene 2002 (Leukemia, Myeloid) : Here, we demonstrate that AML1/Evi-1 interacts with CtBP in SKH1 cells, a leukemic cell line which endogenously overexpresses AML1/Evi-1 and that AML1/Evi-1 requires the interaction with CtBP to repress AML1 induced transactivation ... Here, we demonstrate that AML1/Evi-1 interacts with CtBP in SKH1 cells, a leukemic cell line which endogenously overexpresses AML1/Evi-1 and that AML1/Evi-1 requires the interaction with CtBP to repress AML1 induced transactivation
Atchison et al., EMBO J 2003 : Finally, we found that YY1 , as well as Polycomb, required the co-repressor protein CtBP for repression in vivo
Barnes et al., Nat Struct Biol 2003 : We describe here the binding, phosphorylation and functional regulation of CtBP by the p21 activated kinase 1 (Pak1) ... In the presence of NADH, Pak1 superphosphorylates CtBP and inhibits CtBP dehydrogenase activity, suggesting that preferential phosphorylation of active CtBP may alter secondary structures and influence both enzymatic and corepressor functions ... Pak1 regulation of CtBP represents a new model of corepressor regulation whereby cellular signaling cascades may influence gene expression in mammalian cells
Zhang et al., Cell 2003 : Expression of HIPK2 or exposure to UV irradiation reduced CtBP levels via a proteosome mediated pathway
Yadav et al., Environ Pollut 1987 : BHC stimulated TPO activity in this fish, during both in vitro and in vivo studies
Srinivasan et al., Genes Dev 2004 : These results reveal a new role for CtBP in controlling YY1 DNA binding and recruitment of PcG proteins to DNA
Alpatov et al., Mol Cell Biol 2004 : Nuclear speckle associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP mediated repression of the E-cadherin gene
Chan et al., Blood 2005 (Myelodysplastic Syndromes...) : These results suggest a central role for CtBP in AML1-FOG2 transcriptional repression and implicate coordinated disruption of the AML1 and GATAdevelopmental programs in the pathogenesis of myelodysplasia ... These results suggest a central role for CtBP in AML1-FOG2 transcriptional repression and implicate coordinated disruption of the AML1 and GATAdevelopmental programs in the pathogenesis of myelodysplasia
Zhang et al., Proc Natl Acad Sci U S A 2005 : Homeodomain interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis
Paliwal et al., Mol Cell Biol 2006 (Colonic Neoplasms) : Interaction with ARF resulted in proteasome dependent CtBP degradation ... Both ARF induced CtBP degradation and CtBP small interfering RNA led to p53 independent apoptosis in colon cancer cells ... ARF induction of apoptosis was dependent on its ability to interact with CtBP , and reversal of ARF induced CtBP depletion by CtBP overexpression abrogated ARF induced apoptosis
Sierra et al., Genes Dev 2006 : We conclude that, in addition to regulating the stability of beta-cat, APC facilitates CtBP mediated repression of Wnt target genes in normal, but not in colorectal cancer cells
Wang et al., J Biol Chem 2006 : Previously, we have identified the homeodomain interacting protein kinase 2 as such a regulator and demonstrated that HIPK2 activation causes Ser-422 phosphorylation and degradation of CtBP ... In this study, we found that c-Jun NH2-terminal kinase 1 activation triggered CtBP phosphorylation on Ser-422 and subsequent degradation, inducing p53 independent apoptosis in human lung cancer cells
Oikawa et al., J Biol Chem 2008 : As CtBP is reportedly involved in p53 independent programmed cell death , we examine here whether CIBZ is associated with apoptosis
Gocke et al., PloS one 2008 : ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers
Yang et al., J Mol Biol 2009 : Over-expression of CtBP potentiated the trans-repressive activity of HDGF ; on the other hand, knocking down CtBP attenuated the trans-repressive effect of HDGF ... Finally, fluorescent microscopy showed that HDGF induced the nuclear accumulation of CtBP , suggesting that HDGF forms a transcriptional complex with CtBP
Haga et al., EMBO J 2009 : Finally, CtBP1/BARS activated PLD1 in a synergistic manner with other PLD activators, including ADP-ribosylation factors as demonstrated by in vitro and intact cell systems
Kovi et al., Cell Death Differ 2010 : Expression profiling of BH3-only gene expression in ARF expressing or CtBP-deficient cells revealed that Bik was uniquely regulated by ARF/CtBP in colon cancer cells, whereas additional BH3-only proteins ( Bim, Bmf ) showed CtBP dependent repression in osteosarcoma cells
Neufeld et al., Adv Exp Med Biol 2009 (Colorectal Neoplasms) : This down-regulation of nuclear beta-catenin activity by APC most likely involves nuclear sequestration of beta-catenin from the transcription complex as well as interaction of APC with transcription corepressor CtBP
Skalska et al., PLoS Pathog 2010 (Epstein-Barr Virus Infections) : Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP ... These novel LCLs have revealed that the chromatin remodelling and epigenetic repression of p16(INK4A) requires the interaction of both EBNA3A and EBNA3C with CtBP
Madison et al., Oncogene 2010 : PARP inhibition attenuated activation of p21 transcription by both p53 independent and p53 dependent processes, in a CtBP dependent manner ... PARP inhibition attenuated activation of p21 transcription by both p53 independent and p53 dependent processes, in a CtBP dependent manner
Di et al., Nature structural & molecular biology 2010 : Loss of CtBP from the BRCA1 promoter through estrogen induction, depletion by RNA interference or increased NAD+/NADH ratio leads to HDAC1 dismissal, elevated histone acetylation and increased BRCA1 transcription
Urvalek et al., American journal of translational research 2011 : Interestingly, CtBP promoted sumoylation at K67 of wild-type but not AVALF mutant KLF8, and KLF8 interaction with CtBP was inhibited by treatment with the HDAC inhibitors, ectopic expression of the co-activators, or K93Q or K95Q mutation
Rajabi et al., J Biol Chem 2012 (Breast Neoplasms) : MUC1-C blocks the interaction between TCF7L2 and the C-terminal binding protein (CtBP) , a suppressor of TCF7L2 mediated transcription
Cai et al., PloS one 2012 (Spinal Cord Injuries) : Taken together, it is suggested that : ( i ) in the presence of CtBP , CIBZ gene is involved in secondary injury process and trigger the activation of apoptotic caspase-3 and bax genes independent of p53 ; ( ii ) abrupt down-regulation of CtBP at 8 h is a sign of mitochondria dysfunction and the onset of cell death ; ( iii ) it could be used as an inhibitor or target drug of caspase-3 gene to improve spinal cord function
Paliwal et al., Genes & cancer 2012 : We noted a strict positive correlation between CtBP2 and Tiam1 expression levels and that CtBP promotion of cell migration required CtBP dependent transcriptional activation of Tiam1 ... An analysis of the Tiam1 promoter revealed binding sites for the CtBP interacting Kruppel-like factor 8 (KLF8), and a Tiam1 promoter luciferase reporter was induced in the presence of both KLF8 and CtBP2, consistent with KLF8 dependent CtBP transactivation of Tiam1
Vasilatos et al., Carcinogenesis 2013 (Breast Neoplasms) : Taken together, these results provide novel mechanistic insight into the breast cancer subtype dependent role of LSD1 in mediating HDAC activity and therapeutic efficacy of HDAC inhibitor
Sollerbrant et al., Nucleic Acids Res 1996 (Cell Transformation, Neoplastic) : This might suggest that CtBP binding can regulate E1A mediated transformation by modulating CR1 dependent control of transcription
Yu et al., J Biol Chem 1998 : This finding suggests that BRCA1 regulates gene expression, at least in part, by modulating CtBP mediated transcriptional repression