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SMAD4 — YY1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
YY1
—
SMAD4
(colocalization, imaging technique)
Kurisaki et al., Mol Cell Biol 2003*
-
IRef Biogrid Interaction:
YY1
—
SMAD4
(physical association, affinity chromatography technology)
Kurisaki et al., Mol Cell Biol 2003*
-
IRef Biogrid Interaction:
YY1
—
SMAD4
(direct interaction, pull down)
Kurisaki et al., Mol Cell Biol 2003*
-
IRef Intact Interaction:
Complex of 48 proteins
(physical association, tandem affinity purification)
Brown et al., J Cell Biochem 2008
-
IRef Intact Interaction:
Complex of 43 proteins
(physical association, tandem affinity purification)
Brown et al., J Cell Biochem 2008
Text-mined interactions from Literome
Kurisaki et al., Mol Cell Biol 2003
:
In conclusion,
YY1 represses
Smad transcriptional activities in a gene-specific manner and thus regulates cell differentiation induced by TGF-beta superfamily pathways
Lee et al., Development 2004
:
SMAD mediated modulation of
YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6 dependent chick Nkx2.5 enhancer