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TSC2 — WNT16

Text-mined interactions from Literome

Mak et al., Am J Pathol 2005 (Angiomyolipoma...) : This was supported by the failure of three disease causing TSC2 missense mutants to inhibit Wnt signaling ... Further, the interaction between TSC1/TSC2 and components of the beta-catenin degradation complex was dependent on Wnt stimulation such that binding of tuberin to GSK3 and Axin was reduced in the presence of Wnt whereas the tuberin Dishevelled interaction was increased
Choo et al., Cell 2006 (Mammary Neoplasms, Experimental) : Surprisingly, the phosphorylation of TSC2 by GSK3 is markedly suppressed by Wnt signaling