UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	hsp-6	C37H5.8	0	chrV 4,825,414	hsp-6 encodes a mitochondrial-specific chaperone that is a member of the DnaK/Hsp70 superfamily of molecular chaperones; hsp-6 is believed to be involved in the mitochondrial unfolded protein response, as hsp-6 expression, normally broadly detected from the L1 larval through adult stages of development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-6 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	C07H6.2	C07H6.2	n/a	chrIII 7,521,145	contains similarity to Pfam domain PF07491 Protein phosphatase inhibitor contains similarity to Interpro domain IPR011107 (Protein phosphatase inhibitor)
4	T22F7.1	T22F7.1	n/a	chrIII 544,286	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR006655 (Molybdopterin oxidoreductase, prokaryotic, conserved site), IPR001991 (Sodium:dicarboxylate symporter), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
5	W07E6.3	W07E6.3	n/a	chrII 496,617	contains similarity to Interpro domain IPR000326 (Phosphatidic acid phosphatase type 2/haloperoxidase)
6	C06E1.9	C06E1.9	n/a	chrIII 8,608,051	contains similarity to Interpro domain IPR001680 (WD40 repeat)
7	vha-1	R10E11.8	n/a	chrIII 9,781,407	vha-1 encodes an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-1 is a predicted V-ATPase transmembrane rotor component; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-1, like VHA-12 and VHA-17, antagonizes EFF-1-mediated cell fusion in hypodermal cells; VHA-1 is required for ovulation and embryogenesis, since vha-1(RNAi) animals are sterile with polyploid, unmatured oocytes and dead progeny; VHA-1 is required for alae formation, like the V0 subunits VHA-4 and VHA-5, but not like the V1 subunits VHA-8 or VHA-13; vha-1 shares an operon with vha-2 and R10E11.6; both vha-1 and vha-2 are expressed in the excretory cell, the rectum, and a pair of cells near the anus.
8	F42C5.6	F42C5.6	n/a	chrIV 7,308,755
9	C29G2.3	C29G2.3	n/a	chrV 2,581,907
10	C40A11.3	C40A11.3	n/a	chrII 2,142,086	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
11	T07D3.3	T07D3.3	n/a	chrII 895,627	contains similarity to Homo sapiens CGI16-iso; ENSEMBL:ENSP00000368599
12	eif-3.E	B0511.10	n/a	chrI 10,641,393	eif-3.E encodes the C. elegans ortholog of the translation initiation factor 3 subunit e (eIF3e/Int-6); by homology, EIF-3.E is predicted to be a component of three different protein complexes, the eIF3 translation initiation factor, the 26S proteasome, and the COP9 signalosome; such association suggests that EIF-3.E may serve as a regulatory factor that coordinates the translational and degradative activities of these various complexes; in C. elegans, large-scale RNAi screens indicate that eif-3.E is required for embryonic, larval, and germline development, as well as proper vulval morphogenesis.
13	egg-4	T21E3.1	n/a	chrI 3,933,502	C. elegans EGG-4 protein; contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR000340 (Protein-tyrosine phosphatase, dual specificity)
14	K08F4.5	K08F4.5	n/a	chrIV 10,135,380	contains similarity to Paramecium tetraurelia Chromosome undetermined scaffold_96, whole genome shotgun sequence.; TR:A0EH68
15	str-56	T06C12.3	n/a	chrV 15,873,145	C. elegans STR-56 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR003569 (Cytochrome c-type biogenesis protein CcbS)
16	C46A5.2	C46A5.2	n/a	chrIV 7,761,432	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
17	clec-187	ZK896.6	n/a	chrIV 12,870,360	C. elegans CLEC-187 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR003990 (Pancreatitis-associated protein), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
18	nhr-166	C49D10.2	n/a	chrII 3,881,165	C. elegans NHR-166 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
19	F25B4.2	F25B4.2	n/a	chrV 5,710,856	contains similarity to Pfam domain PF04710 Pellino contains similarity to Interpro domain IPR006800 (Pellino)
20	nhr-253	ZK6.4	n/a	chrV 397,792	C. elegans NHR-253 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000679 (Zinc finger, GATA-type), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
21	nhr-125	R02D1.1	n/a	chrV 4,322,934	C. elegans NHR-125 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
22	pqn-27	E01G4.4	n/a	chrII 13,454,655	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
23	Y47H9C.2	Y47H9C.2	n/a	chrI 11,842,812	contains similarity to Pfam domain PF01529 DHHC zinc finger domain contains similarity to Interpro domain IPR001594 (Zinc finger, DHHC-type)
24	C11D9.1	C11D9.1	n/a	chrI 4,424,085	contains similarity to Pfam domain PF00621 RhoGEF domain contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR001478 (PDZ/DHR/GLGF)
25	F41G3.2	F41G3.2	n/a	chrII 6,759,863
26	lgc-5	F17E9.7	n/a	chrIV 8,343,385	C. elegans LGC-5 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
27	inx-7	K02B2.4	n/a	chrIV 5,945,314	C. elegans INX-7 protein; contains similarity to Pfam domain PF00876 Innexin contains similarity to Interpro domain IPR000990 (Innexin)
28	pgp-7	T21E8.2	n/a	chrX 10,867,530	pgp-7 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-7 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-7 activity via RNAi results in no obvious defects, the precise role of PGP-7 in C. elegans development and/or behavior is not yet known; pgp-7 promoter-gfp fusion proteins are expressed in the rays of the adult male tail.
29	tsp-3	Y39E4B.4	n/a	chrIII 13,213,403	C. elegans TSP-3 protein; contains similarity to Pfam domain PF00335 Tetraspanin family contains similarity to Interpro domain IPR000301 (CD9/CD37/CD63 antigen)
30	T03G6.3	T03G6.3	n/a	chrX 2,613,474	contains similarity to Pfam domain PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase contains similarity to Interpro domains IPR017849 (Alkaline phosphatase-like, alpha/beta/alpha), IPR002591 (Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase), IPR017850 (Alkaline-phosphatase-like, core domain)
31	T24F1.2	T24F1.2	n/a	chrII 11,304,196	contains similarity to Drosophila melanogaster Flybase gene name is CG7744-PA;; FLYBASE:CG7744
32	F28B3.1	F28B3.1	n/a	chrI 4,946,480	contains similarity to Pfam domain PF00501 AMP-binding enzyme contains similarity to Interpro domains IPR000010 (Proteinase inhibitor I25, cystatin), IPR000873 (AMP-dependent synthetase and ligase)
33	R02E12.4	R02E12.4	n/a	chrX 4,005,562	contains similarity to Pfam domains PF03148 (Tektin family) , PF00097 (Zinc finger, C3HC4 type (RING finger)) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000435 (Tektin), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
34	C34C6.2	C34C6.2	n/a	chrII 8,681,696	contains similarity to Homo sapiens KIAA1219; ENSEMBL:ENSP00000302059
35	T05E8.3	T05E8.3	n/a	chrI 5,475,882	The T05E8.3 gene encodes a divergent DEAH helicase that is (apparently) unique to Caenorhabditis; it has no well-characterized orthologs in the complete Drosophila or S. cerevisiae genomes, and no obvious orthologs in the draft human genome sequence either.
36	srt-1	C13B7.1	n/a	chrV 2,436,754	C. elegans SRT-1 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
37	F54E2.5	F54E2.5	n/a	chrV 2,814,230	contains similarity to Pfam domain PF04789 Protein of unknown function (DUF621) contains similarity to Interpro domains IPR006874 (Protein of unknown function DUF621), IPR003091 (Voltage-dependent potassium channel)
38	irk-2	M02A10.2	n/a	chrX 706,700	irk-2 encodes an inwardly rectifying potassium channel based on sequence homology to the the human potassium channel genes KCNJ1/KCNJ2.
39	C03E10.3	C03E10.3	n/a	chrV 11,287,593	contains similarity to Clostridium perfringens Probable cytochrome C-type biogenesis protein.; TR:Q8XME8
40	F53F4.3	F53F4.3	n/a	chrV 13,592,537	F53F4.3 encodes a putative alpha-tubulin folding cofactor B, orthologous to human CKAP1 (OMIM:601303); F53F4.3 is dispensable in early embryos for microtubule nucleation or elongation, and has no obvious function in mass RNAi assays.
41	T07D1.5	T07D1.5	n/a	chrX 2,419,146
42	F09E10.5	F09E10.5	n/a	chrX 1,492,033
43	T07F12.1	T07F12.1	n/a	chrX 4,895,096	T07F12.1 encodes a member of the histidine phosphatase superfamily orthologous to Bombyx mori ecdysteroid phosphate phosphatase (EPP), human STS1 (OMIM:609201) and human UBASH3A (OMIM:605736); in cell culture, recombinant T07F12.1 is a cytosolic enzyme with steroid phosphatase activity on ecdysone 22-phosphate (E22P), 3-epiecdysone 22-phosphate, 3-epiecdysone 2-phosphate substrates, and prednisolone 21-phosphate substrates, with E22P being preferred; T07F12.1 has no activity against 3-epiecdysone 3(alpha)-phosphate or 1-dehydrotestosterone sodium sulphate; unlike its Bombyx or mammalian orthologs, T07F12.1 lacks non-catalytic SH3 and UBA domains; T07F12.1 is paralogous to C. elegans C52E4.7, F09C12.8, F53B6.7, and F55A11.11.
44	T14B4.2	T14B4.2	n/a	chrII 6,736,402	contains similarity to Pfam domain PF01084 Ribosomal protein S18 contains similarity to Interpro domain IPR001648 (Ribosomal protein S18)
45	C08B6.7	C08B6.7	n/a	chrV 10,132,247	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
46	F54D10.8	F54D10.8	n/a	chrII 3,826,789	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
47	B0412.3	B0412.3	n/a	chrIII 802,243	contains similarity to Pfam domain PF07919 Protein of unknown function (DUF1683) contains similarity to Interpro domain IPR012880 (Protein of unknown function DUF1683, C-terminal)
48	srxa-10	R10E11.7	n/a	chrIII 9,795,820	C. elegans SRXA-10 protein; contains similarity to Pfam domain PF03383 Caenorhabditis serpentine receptor-like protein, class xa contains similarity to Interpro domain IPR005047 (Protein of unknown function DUF286, G protein-coupled receptor-like putative Caenorhabditis species)
49	D1005.1	D1005.1	n/a	chrX 1,481,966	contains similarity to Pfam domains PF08442 (ATP-grasp domain) , PF00549 (CoA-ligase) , PF02629 (CoA binding domain) contains similarity to Interpro domains IPR013650 (ATP-grasp fold, succinyl-CoA synthetase-type), IPR014608 (ATP-citrate synthase), IPR016142 (Citrate synthase-like, large alpha subdomain), IPR005811 (ATP-citrate lyase/succinyl-CoA ligase), IPR016141 (Citrate synthase-like, core), IPR005809 (Succinyl-CoA synthetase, beta subunit), IPR016143 (Citrate synthase-like, small alpha subdomain), IPR005810 (Succinyl-CoA ligase, alpha subunit), IPR016040 (NAD(P)-binding), IPR013816 (ATP-grasp fold, subdomain 2), IPR017440 (ATP-citrate lyase/succinyl-CoA ligase, active site), IPR003781 (CoA-binding), IPR016102 (Succinyl-CoA synthetase-like)
50	clec-218	W02D7.2	n/a	chrV 8,309,344	C. elegans CLEC-218 protein; contains similarity to Pfam domains PF00092 (von Willebrand factor type A domain) , PF00059 (Lectin C-type domain) contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR002035 (von Willebrand factor, type A)