UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	utx-1	D2021.1	0	chrX 8,560,128	utx-1 encodes a putative histone H3 di/trimethyllysine-27 (H3K27me2/me3) demethylase, required for embryonic viability and vulval development, and for high brood sizes, locomotion, and growth sizes; UTX-1 contains a JmjC domain, is orthologous to human UTX and UTY, and is paralogous to human JMJD3; by orthology, UTX-1 is expected to antagonize transcriptional repression by polycomb repressor complexes, which mark stem cells (and presumably germline) by H3K27me3-mediated repression of somatic genes.
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	F14F9.4	F14F9.4	n/a	chrV 5,134,905	contains similarity to Interpro domain IPR002867 (Zinc finger, C6HC-type)
4	F52D10.2	F52D10.2	n/a	chrX 11,590,643	contains similarity to Interpro domains IPR011993 (Pleckstrin homology-type), IPR006020 (Phosphotyrosine interaction region)
5	ins-34	F52B11.6	n/a	chrIV 14,107,090	ins-34 encodes an insulin-like peptide.
6	amx-1	R13G10.2	n/a	chrIII 3,824,311	C. elegans AMX-1 protein; contains similarity to Pfam domains PF01593 (Flavin containing amine oxidoreductase) , PF01266 (FAD dependent oxidoreductase) contains similarity to Interpro domains IPR006076 (FAD dependent oxidoreductase), IPR001613 (Flavin-containing amine oxidase), IPR000960 (Flavin-containing monooxygenase FMO), IPR002937 (Amine oxidase), IPR016040 (NAD(P)-binding), IPR007526 (SWIRM)
7	F19C6.3	F19C6.3	n/a	chrX 10,007,249	contains similarity to Pfam domains PF00008 (EGF-like domain) , PF00093 (von Willebrand factor type C domain) contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR008037 (Proteinase inhibitor I19, pacifastin), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR001881 (EGF-like calcium-binding), IPR013032 (EGF-like region, conserved site), IPR001007 (von Willebrand factor, type C)
8	E04D5.2	E04D5.2	n/a	chrII 10,420,700	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
9	ZK418.5	ZK418.5	n/a	chrIII 7,073,217	contains similarity to Mus musculus Transmembrane protein 147.; SW:Q9CQG6
10	T24E12.1	T24E12.1	n/a	chrII 3,786,852	contains similarity to Interpro domain IPR009071 (High mobility group box, HMG)
11	sedl-1	W05H7.3	n/a	chrX 1,439,758	C. elegans SEDL-1 protein; contains similarity to Pfam domain PF04628 Sedlin, N-terminal conserved region contains similarity to Interpro domains IPR011012 (Longin-like), IPR006722 (Sedlin)
12	sup-10	R09G11.1	n/a	chrX 17,529,998	C. elegans SUP-10 protein ;
13	T10B5.3	T10B5.3	n/a	chrV 1,866,374	contains similarity to Pfam domain PF08162 NUC189 domain contains similarity to Interpro domain IPR012979 (Protein of unknown function NUC189, C-terminal)
14	pup-3	F59A3.9	n/a	chrI 5,532,199	pup-3 encodes a template-independent poly(U) polymerase with 3'' end RNA substrates, distantly similar to human ZCCHC6 and ZCCHC11; PUP-3 is paralogous to the GLD-2 family of poly(A) polymerases; PUP-3 has no obvious function in mass RNAi assays.
15	R186.1	R186.1	n/a	chrV 12,962,447	contains similarity to Pfam domain PF05742 Protein of unknown function (DUF833) contains similarity to Interpro domain IPR008551 (Protein of unknown function DUF833)
16	F14F7.5	F14F7.5	n/a	chrIII 13,033,511	contains similarity to Pfam domain PF02206 Domain of unknown function contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003125 (Protein of unknown function WSN)
17	Y53C12C.1	Y53C12C.1	n/a	chrII 9,827,141	Y53C12C.1 encodes a divergent paired-like homeodomain protein that does not belong to the Q50, K50, or S50 classes; it has no obvious function in mass RNAi assays.
18	C07E3.6	C07E3.6	n/a	chrII 10,368,675	contains similarity to Pfam domain PF00046 Homeobox domain contains similarity to Interpro domains IPR012287 (Homeodomain-related), IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
19	T05G5.1	T05G5.1	n/a	chrIII 9,741,123	contains similarity to Pfam domain PF00008 EGF-like domain contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006209 (EGF-like)
20	B0454.9	B0454.9	n/a	chrII 3,053,483	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
21	tra-4	F53B3.1	n/a	chrX 2,855,643	C. elegans TRA-4 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR008162 (Inorganic pyrophosphatase), IPR015880 (Zinc finger, C2H2-like), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
22	K09E3.6	K09E3.6	n/a	chrX 17,114,487	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
23	B0310.6	B0310.6	n/a	chrX 530,795
24	fbxa-103	F09C3.4	n/a	chrI 14,288,863	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
25	C54F6.5	C54F6.5	n/a	chrV 7,529,245
26	F21D5.6	F21D5.6	n/a	chrIV 8,740,745	contains similarity to Xenopus laevis Ribonuclease H2 subunit B (RNase H2 subunit B) (Ribonuclease HIssubunit B).; SW:Q5HZP1
27	srh-68	T21B4.5	n/a	chrII 12,507,810	C. elegans SRH-68 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR002379 (ATPase, F0/V0 complex, subunit C)
28	C05G5.2	C05G5.2	n/a	chrX 14,748,776	contains similarity to Xenopus laevis Nucleolar phosphoprotein.; TR:Q91803
29	egl-26	C23H3.1	n/a	chrII 70,469	egl-26 encodes a protein that contains an H-box and an NC domain that is a member of the LRAT (lecithin retinol acyltransferase) subfamily of the NlpC/P60 superfamily of enzymes; egl-26 activity is required for fertility, egg laying, and vulval development, specifically the connection of the uterus to the vulva mediated by proper morphogenesis of vulF, the most dorsal vulval cell; EGL-26 is an apical membrane protein that is expressed in many cells, including vulF, and appears to be expressed near the vulva and uterus only during the L4 larval stage; EGL-26 membrane localization is necessary for its function.
30	F10E7.5	F10E7.5	n/a	chrII 7,112,410	contains similarity to Pfam domain PF00466 Ribosomal protein L10 contains similarity to Interpro domain IPR001790 (Ribosomal protein L10)
31	tor-1	Y37A1B.12	n/a	chrIV 13,985,958	C. elegans TOR-1 protein; contains similarity to Pfam domain PF06309 Torsin contains similarity to Interpro domains IPR017378 (Torsin, subgroup), IPR001270 (Chaperonin clpA/B), IPR000641 (CbxX/CfqX), IPR003593 (AAA+ ATPase, core), IPR010448 (Torsin)
32	gur-3	ZC504.5	n/a	chrX 10,404,346	gur-3 encodes a predicted seven-transmembrane protein related to the gustatory class of receptors in Drosophila.
33	F43E2.1	F43E2.1	n/a	chrII 7,376,369
34	K01A2.3	K01A2.3	n/a	chrII 315,416
35	F28C6.1	F28C6.1	n/a	chrII 8,591,963	F28C6.1 encodes an AP-2-like transcription factor that is ~60% identical to that of F28C6.2 which lies immediately adjacent to F28C6.1 on chromosome II; loss of F28C6.1 activity via large-scale RNAi experiments results in embryonic and larval lethality.
36	M01B2.10	M01B2.10	n/a	chrV 15,261,657	contains similarity to Homo sapiens Phytanoyl-CoA 2-hydroxylase-interacting protein-like; ENSEMBL:ENSP00000362987
37	cpf-2	F56A8.6	n/a	chrIII 13,267,824	C. elegans CPF-2 protein; contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR012677 (Nucleotide-binding, alpha-beta plait), IPR003954 (RNA recognition, region 1), IPR000504 (RNA recognition motif, RNP-1)
38	D1025.1	D1025.1	n/a	chrX 14,521,627	contains similarity to Homo sapiens Splice isoform 3 of Q9ULU4 Protein kinase C binding protein 1; ENSEMBL:ENSP00000262975
39	C52E12.4	C52E12.4	n/a	chrII 7,017,594	contains similarity to Pfam domains PF01477 (PLAT/LH2 domain) , PF02141 (DENN (AEX-3) domain) , PF03456 (uDENN domain) , PF03455 (dDENN domain) , PF02759 (RUN domain) contains similarity to Interpro domains IPR005112 (dDENN), IPR001024 (Lipoxygenase, LH2), IPR008976 (Lipase/lipooxygenase, PLAT/LH2), IPR004012 (RUN), IPR005113 (uDENN), IPR001194 (DENN)
40	cec-1	ZK1236.2	n/a	chrIII 8,427,378	cec-1 encodes a nuclear protein with a chromodomain that is ubiquitously expressed in somatic cells, but is dispensable for embryonic survival or gross adult morphology.
41	irx-1	C36F7.1	n/a	chrI 9,538,707	irx-1 encodes a homeodomain-containing protein that is most similar to members of the Iroquois subclass of TALE (three amino acid loop extension) superclass atypical homeodomain proteins; IRX-1 is predicted to function as a transcriptional regulator during development, but as loss of irx-1 activity via RNAi results in no obvious defects, the precise role of irx-1 in C. elegans development and/or behavior is not yet known.
42	nhr-151	C06B8.3	n/a	chrV 15,484,320	C. elegans NHR-151 protein ;
43	Y9D1A.2	Y9D1A.2	n/a	chrII 7,450,882	contains similarity to Homo sapiens Uncharacterized protein ENSP00000370861; ENSEMBL:ENSP00000370861
44	pro-1	R166.4	n/a	chrII 10,540,649	pro-1 encodes a WD-repeat-containing protein that is orthologous to Saccharomyces cerevisiae IPI3; pro-1 activity is required for ribosome biogenesis and specifically, for efficient processing of intervening sequence 2 (ITS2) from rRNA intermediates during 26S rRNA maturation; during development, pro-1 is essential for larval growth, fertility, and normal cell division patterns; in addition, pro-1 is required cell autonomously in the somatic gonad for proper spatial and temporal regulation of germline development and proliferation; a pro-1 promoter::gfp fusion construct reveals that pro-1 is widely expressed in the embryo as well as in every major post-embryonic lineage including the somatic gonad.
45	T05H4.10	T05H4.10	n/a	chrV 6,420,809	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domains IPR000357 (HEAT), IPR016024 (Armadillo-type fold)
46	hst-2	C34F6.4	n/a	chrX 11,205,546	hst-2 encodes the C. elegans ortholog of the heparan sulfate modifying enzyme 2O-sulfotransferase; by homology, HST-2 is predicted to function in heparan sulfate biosynthesis by catalyzing the chain-modifying sulfation of the C2 hydroxyl group of hexuronic acid; during development, hst-2 activity is required for normal body size, cell migration, and nervous system development; an hst-2::gfp reporter fusion is first expressed in embryos, continuing on through adulthood; expression is detected in many tissues, including the pharynx, hypodermis, muscles, vulva, and distal tip cells (DTCs) of the somatic gonad.
47	ceh-41	T26C11.5	n/a	chrX 1,847,671	ceh-41 encodes a a ONECUT class CUT homeobox protein with a single N-terminal OCAM domain; the OCAM domain is a nematode-specific motif conserved between CEH-21, CEH-41, and T02B5.2; ceh-41 is one of three nematode-specific ONECUT genes in a cluster with ceh-21 and ceh-39; ceh-41 has no obvious function in mass RNAi assays.
48	Y75B8A.5	Y75B8A.5	n/a	chrIII 12,116,403	contains similarity to Interpro domain IPR000372 (Leucine-rich repeat, cysteine-rich flanking region, N-terminal)
49	gpa-8	F56H9.3	n/a	chrV 12,639,639	gpa-8 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; expressed in URX, AQR, and PQR sensory cells.
50	F08B6.3	F08B6.3	n/a	chrI 6,759,203	contains similarity to Pfam domain PF00036 EF hand contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR008080 (Parvalbumin), IPR000886 (Endoplasmic reticulum, targeting sequence)