UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	cogc-1	Y54E10A.2	0	chrI 3,244,479	cogc-1 encodes an ortholog of mammalian COG-1/ldlBp (OMIM:606973, mutated in congenital disorder of glycosylation type II), a subunit of lobe A of the conserved oligomeric Golgi complex (COGC); COGC-1 is required for normal gonadal distal tip cell migration, a process that also requires COGC-3 and six other orthologs of COGC subunits; COGC-1 is also required for normal vulval morphology, growth rate, ventral nerve cord fasciculation, and adult locomotion; COGC-1 has a predicted coiled-coil N-terminal domain; COGC-1 co-precipitates with COGC-3, and the amount of COGC-1 is lowered in a cogc-3 mutant, implying that these proteins not only bind one another but stabilize one another in vivo; in cogc-1 mutants, MIG-23 is abnormally localized and expressed within cells; in cogc-1 mutants, MIG-23's substrate MIG-17 is underglycosylated and fails to bind to the gonadal basement membrane, but is still secreted normally from muscle cells; cogc-1, cogc-3, and mig-17 null mutants do not enhance one another, indicating a shared genetic pathway; like other lobe A subunits in both C. elegans and S. cerevisiae, COGC-1 is strongly required for normal function, while lobe B subunits are only partially required in either worms or yeast.