UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	GCR1	YPL075W	553	n/a	chrXVI 413,808	Transcriptional activator of genes involved in glycolysis DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
2	LEU3	YLR451W	553	n/a	chrXII 1,037,423	Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis
3	SWI6	YLR182W	553	n/a	chrXII 519,145	Transcription cofactor, forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition involved in meiotic gene expression cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization
4	MCM1	YMR043W	553	n/a	chrXIII 354,301	Transcription factor involved in cell-type-specific transcription and pheromone response plays a central role in the formation of both repressor and activator complexes
5	TRK1	YJL129C	553	n/a	chrX 175,452	Component of the Trk1p-Trk2p potassium transport system 180 kDa high affinity potassium transporter phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation
6	KIN2	YLR096W	553	n/a	chrXII 334,311	Serine/threonine protein kinase involved in regulation of exocytosis localizes to the cytoplasmic face of the plasma membrane closely related to Kin1p
7	PMS1	YNL082W	553	n/a	chrXIV 474,701	ATP-binding protein required for mismatch repair in mitosis and meiosis functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
8	RED1	YLR263W	553	n/a	chrXII 671,581	Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division critical for coupling checkpoint signaling to SC formation interacts with Hop1p, Mec3p and Ddc1p
9	TUP1	YCR084C	553	n/a	chrIII 261,381	General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
10	CBF1	YJR060W	553	n/a	chrX 549,286	Dual function helix-loop-helix protein binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI) affects nucleosome positioning at this motif associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression associates with kinetochore proteins and required for efficient chromosome segregation
11	RGR1	YLR071C	553	n/a	chrXII 277,002	Subunit of the RNA polymerase II mediator complex associates with core polymerase subunits to form the RNA polymerase II holoenzyme required for glucose repression, HO repression, RME1 repression and sporulation
12	ACE2	YLR131C	553	n/a	chrXII 405,666	Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation
13	AFT1	YGL071W	553	n/a	chrVII 373,048	Transcription factor involved in iron utilization and homeostasis binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
14	URE2	YNL229C	553	n/a	chrXIV 219,669	Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source has glutathione peroxidase activity and can mutate to acquire GST activity altered form creates [URE3] prion
15	RSC6	YCR052W	553	n/a	chrIII 215,719	Component of the RSC chromatin remodeling complex essential for mitotic growth homolog of SWI/SNF subunit Swp73p
16	ASF1	YJL115W	553	n/a	chrX 196,706	Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed plays a role in regulating Ty1 transposition
17	HIR2	YOR038C	553	n/a	chrXV 404,074	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription recruits Swi-Snf complexes to histone gene promoters promotes heterochromatic gene silencing with Asf1p
18	SWI3	YJL176C	553	n/a	chrX 93,291	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
19	CHD1	YER164W	553	n/a	chrV 507,595	Nucleosome remodeling factor that functions in regulation of transcription elongation contains a chromo domain, a helicase domain and a DNA-binding domain component of both the SAGA and SLIK complexes
20	ORC2	YBR060C	553	0	chrII 361,583	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing interacts with Spp1p and with trimethylated histone H3 phosphorylated by Cdc28p
21	MRS6	YOR370C	553	n/a	chrXV 1,030,088	Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) sequence similarity to mammalian choroideraemia gene
22	PDC2	YDR081C	553	n/a	chrIV 608,692	Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes
23	TIP20	YGL145W	553	n/a	chrVII 231,295	Peripheral membrane protein required for fusion of COPI vesicles with the ER prohibits back-fusion of COPII vesicles with the ER forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
24	SKT5	YBL061C	553	n/a	chrII 106,361	Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p has similarity to Shc1p, which activates Chs3p during sporulation
25	LST4	YKL176C	553	n/a	chrXI 116,743	Protein possibly involved in a post-Golgi secretory pathway required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
26	SKI2	YLR398C	553	n/a	chrXII 917,087	Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
27	SPT10	YJL127C	553	n/a	chrX 183,259	Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box
28	SPT21	YMR179W	553	n/a	chrXIII 620,996	Protein with a role in transcriptional silencing required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci functionally related to Spt10p
29	SNU114	YKL173W	553	n/a	chrXI 124,030	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome binds directly to U5 snRNA proposed to be involved in conformational changes of the spliceosome similarity to ribosomal translocation factor EF-2
30	SAP190	YKR028W	553	n/a	chrXI 495,807	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function member of a family of similar proteins including Sap4p, Sap155p, and Sap185p
31	CAF4	YKR036C	553	n/a	chrXI 509,667	WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission
32	NUP170	YBL079W	553	n/a	chrII 77,513	Subunit of the nuclear pore complex (NPC), required for NPC localization of specific nucleoporins involved in nuclear envelope permeability and chromosome segregation has similar to Nup157p essential role, with Nup157p, in NPC assembly
33	SHE1	YBL031W	553	n/a	chrII 162,207	Mitotic spindle protein that interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure
34	HSL7	YBR133C	553	n/a	chrII 503,045	Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p
35	YLF2	YHL014C	553	n/a	chrVIII 76,705	Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1 the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
36	GIC1	YHR061C	553	n/a	chrVIII 222,006	Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain
37	SET1	YHR119W	553	n/a	chrVIII 347,664	Histone methyltransferase, subunit of the COMPASS (Set1C) complex COMPASS methylates histone H3K4 Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination required in transcriptional silencing near telomeres and at silent mating type loci has a SET domain
38	UME6	YDR207C	553	n/a	chrIV 866,267	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
39	UBP12	YJL197W	553	n/a	chrX 65,687	Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins
40	SLN1	YIL147C	553	n/a	chrIX 71,622	Histidine kinase osmosensor that regulates a MAP kinase cascade transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
41	BOI2	YER114C	553	n/a	chrV 392,151	Protein implicated in polar growth, functionally redundant with Boi1p interacts with bud-emergence protein Bem1p contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
42	TAO3	YIL129C	553	n/a	chrIX 109,672	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
43	IRR1	YIL026C	553	n/a	chrIX 306,203	Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
44	SUM1	YDR310C	553	n/a	chrIV 1,082,722	Transcriptional repressor required for mitotic repression of middle sporulation-specific genes also acts as general replication initiation factor involved in telomere maintenance, chromatin silencing regulated by pachytene checkpoint
45	SMC3	YJL074C	553	n/a	chrX 301,003	Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells also required, with Rec8p, for cohesion and recombination during meiosis phylogenetically conserved SMC chromosomal ATPase family member
46	HIR3	YJR140C	553	n/a	chrX 693,223	Subunit of the HIR complex a nucleosome assembly complex involved in regulation of histone gene transcription involved in position-dependent gene silencing and nucleosome reassembly ortholog of human CABIN1 protein
47	HSH155	YMR288W	553	n/a	chrXIII 847,028	U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation similarity to the mammalian U2 snRNP-associated splicing factor SAP155
48	CTF18	YMR078C	553	n/a	chrXIII 423,615	Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion may have overlapping functions with Rad24p in the DNA damage replication checkpoint
49	RTF1	YGL244W	553	n/a	chrVII 42,336	Subunit of the RNA polymerase II-associated Paf1 complex directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements involved in telomere maintenance involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
50	NNF2	YGR089W	553	n/a	chrVII 658,365	Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation