UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	RAD3	YER171W	559	n/a	chrV 528,250	5' to 3' DNA helicase, involved in nucleotide excision repair and transcription subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPD protein mutant has aneuploidy tolerance
2	ADH4	YGL256W	559	n/a	chrVII 15,733	Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases transcription is induced in response to zinc deficiency
3	IDI1	YPL117C	559	n/a	chrXVI 328,297	Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway required for viability
4	STE4	YOR212W	559	n/a	chrXV 743,545	G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling may recruit Rho1p to the polarized growth site during mating contains WD40 repeats
5	ELM1	YKL048C	559	n/a	chrXI 348,175	Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis required for the regulation of other kinases forms part of the bud neck ring
6	THI80	YOR143C	559	n/a	chrXV 601,862	Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
7	RRN3	YKL125W	559	n/a	chrXI 209,188	Protein required for transcription of rDNA by RNA polymerase I transcription factor independent of DNA template involved in recruitment of RNA polymerase I to rDNA
8	MUD2	YKL074C	559	n/a	chrXI 295,401	Protein involved in early pre-mRNA splicing component of the pre-mRNA-U1 snRNP complex, the commitment complex interacts with Msl5p/BBP splicing factor and Sub2p similar to metazoan splicing factor U2AF65
9	LAS1	YKR063C	559	n/a	chrXI 561,543	Essential nuclear protein possibly involved in bud formation and morphogenesis mutants require the SSD1-v allele for viability
10	POP8	YBL018C	559	n/a	chrII 186,236	Subunit of both RNase MRP and nuclear RNase P RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
11	TRS20	YBR254C	559	n/a	chrII 723,999	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
12	RRP4	YHR069C	559	n/a	chrVIII 234,118	Exosome non-catalytic core component involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm predicted to contain RNA binding domains has similarity to human hRrp4p (EXOSC2)
13	YHR127W	YHR127W	559	n/a	chrVIII 361,278	Protein of unknown function localizes to the nucleus required for asymmetric localization of Kar9p during mitosis
14	SKN7	YHR206W	559	n/a	chrVIII 513,666	Nuclear response regulator and transcription factor physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets part of a branched two-component signaling system required for optimal induction of heat-shock genes in response to oxidative stress involved in osmoregulation
15	SAK1	YER129W	559	n/a	chrV 418,995	Upstream serine/threonine kinase for the SNF1 complex partially redundant with Elm1p and Tos3p members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
16	PZF1	YPR186C	559	n/a	chrXVI 910,377	Transcription factor IIIA (TFIIIA) essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III not involved in transcription of other RNAP III genes nine conserved zinc fingers may also bind 5S rRNA
17	FCY21	YER060W	559	n/a	chrV 275,360	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
18	GLE2	YER107C	559	n/a	chrV 373,996	Component of the Nup82 subcomplex of the nuclear pore complex required for polyadenylated RNA export but not for protein import homologous to S. pombe Rae1p
19	LSM4	YER112W	559	n/a	chrV 387,513	Lsm (Like Sm) protein part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
20	PEA2	YER149C	559	n/a	chrV 466,839	Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx forms polarisome complex with Bni1p, Bud6p, and Spa2p localizes to sites of polarized growth
21	RFC2	YJR068W	559	n/a	chrX 568,173	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
22	ASG1	YIL130W	559	n/a	chrIX 104,229	Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
23	DPH1	YIL103W	559	n/a	chrIX 172,389	Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph2p and Kti11p
24	YIL092W	YIL092W	559	n/a	chrIX 190,016	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
25	SAS2	YMR127C	559	n/a	chrXIII 522,837	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing member of the MYSTacetyltransferase family
26	FKH2	YNL068C	559	n/a	chrXIV 496,995	Forkhead family transcription factor with a major role in the expression of G2/M phase genes positively regulates transcriptional elongation negative role in chromatin silencing at HML and HMR substrate of the Cdc28p/Clb5p kinase
27	BRE2	YLR015W	559	n/a	chrXII 175,985	Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p similar to trithorax-group protein ASH2L
28	CTK2	YJL006C	559	n/a	chrX 423,623	Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity
29	PFD1	YJL179W	559	n/a	chrX 88,951	Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it involved in the biogenesis of actin and of alpha- and gamma-tubulin
30	YGR093W	YGR093W	559	n/a	chrVII 671,149	Putative protein of unconfirmed function green fluorescent protein (GFP)-fusion protein localizes to the nucleus
31	RRP46	YGR095C	559	n/a	chrVII 676,006	Exosome non-catalytic core component involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
32	NRD1	YNL251C	559	n/a	chrXIV 173,451	RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) complex mediates termination of snoRNAs and cryptic unstable transcripts (CUTs) interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5 H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites required for 3' end maturation of nonpolyadenylated RNAs
33	RTC4	YNL254C	559	n/a	chrXIV 168,645	Protein of unknown function null mutation suppresses cdc13-1 temperature sensitivity (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
34	VPS9	YML097C	559	n/a	chrXIII 79,012	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors binds ubiquitin
35	STD1	YOR047C	559	n/a	chrXV 417,014	Protein involved in control of glucose-regulated gene expression interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p regulator of transcription factor Rgt1p interactions with Pma1p appear to propagate [GAR+]
36	YPL108W	YPL108W	559	n/a	chrXVI 348,699	Cytoplasmic protein of unknown function non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism GFP-fusion protein is induced in response to the DNA-damaging agent MMS
37	MET31	YPL038W	559	n/a	chrXVI 480,801	Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met32p
38	MAK3	YPR051W	559	n/a	chrXVI 665,225	Catalytic subunit of N-terminal acetyltransferase of the NatC type required for replication of dsRNA virus
39	YML108W	YML108W	559	n/a	chrXIII 54,951	Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus YML108W is not an essential gene
40	RPC11	YDR045C	559	n/a	chrIV 548,144	RNA polymerase III subunit C11 mediates pol III RNA cleavage activity and is important for termination of transcription homologous to TFIIS
41	RBA50	YDR527W	559	n/a	chrIV 1,491,753	Protein involved in transcription interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p has similarity to human RPAP1
42	YML096W	YML096W	559	n/a	chrXIII 80,697	Putative protein of unknown function with similarity to asparagine synthetases green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm YML096W is not an essential gene and partially overlaps the verified gene RAD10
43	RNH202	YDR279W	559	n/a	chrIV 1,019,894	Ribonuclease H2 subunit, required for RNase H2 activity related to human AGS2 that causes Aicardi-Goutieres syndrome
44	YDR370C	YDR370C	559	n/a	chrIV 1,218,446	Putative protein of unknown function
45	IRC25	YLR021W	559	n/a	chrXII 183,892	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome may regulate formation of proteasome isoforms with alternative subunits under different conditions
46	RRG7	YOR305W	559	n/a	chrXV 889,386	Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) YOR305W is not an essential gene
47	MCH5	YOR306C	559	n/a	chrXV 890,649	Plasma membrane riboflavin transporter facilitates the uptake of vitamin B2 required for FAD-dependent processes sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
48	RSA1	YPL193W	559	n/a	chrXVI 181,975	Protein involved in the assembly of 60S ribosomal subunits functionally interacts with Dbp6p functions in a late nucleoplasmic step of the assembly
49	YOR283W	YOR283W	559	n/a	chrXV 847,799	Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase YOR283W is not an essential gene
50	FAP7	YDL166C	559	8e-101	chrIV 163,745	Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D