UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	ADE8	YDR408C	469	n/a	chrIV 1,288,537	Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
2	GAL80	YML051W	469	n/a	chrXIII 172,247	Transcriptional regulator involved in the repression of GAL genes in the absence of galactose inhibits transcriptional activation by Gal4p inhibition relieved by Gal3p or Gal1p binding
3	RAD52	YML032C	469	n/a	chrXIII 213,222	Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA anneals complementary single-stranded DNA involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
4	WHI2	YOR043W	469	n/a	chrXV 411,600	Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation regulates growth during the diauxic shift negative regulator of G1 cyclin expression
5	SKI3	YPR189W	469	n/a	chrXVI 914,813	Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
6	IRA2	YOL081W	469	n/a	chrXV 175,689	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
7	SPE2	YOL052C	469	n/a	chrXV 233,041	S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
8	YSR3	YKR053C	469	n/a	chrXI 534,674	Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism has similarity to Lcb3p
9	RDS1	YCR106W	469	n/a	chrIII 312,207	Zinc cluster transcription factor involved in conferring resistance to cycloheximide
10	FIG2	YCR089W	469	n/a	chrIII 269,848	Cell wall adhesin, expressed specifically during mating may be involved in maintenance of cell wall integrity during mating
11	SPT5	YML010W	469	n/a	chrXIII 249,272	Protein involved in regulating Pol I and Pol II transcription and pre-mRNA processing forms a complex with Spt4p contains a C-terminal repeat domain that is a target for phosphorylation by Sgv1p
12	GPI10	YGL142C	469	n/a	chrVII 237,194	Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure human PIG-Bp is a functional homolog
13	PMT2	YAL023C	469	n/a	chrI 107,411	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein Ser/Thr residues involved in ER quality control acts in a complex with Pmt1p, can instead interact with Pmt5 target for new antifungal
14	AFG1	YEL052W	469	n/a	chrV 57,335	Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits localized to matrix face of the mitochondrial inner membrane member of the AAA family but lacks a protease domain
15	HEM12	YDR047W	469	0	chrIV 552,404	Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
16	MYO4	YAL029C	469	n/a	chrI 90,062	One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
17	DUR1,2	YBR208C	469	n/a	chrII 639,456	Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3 expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
18	RTG1	YOL067C	469	n/a	chrXV 202,251	Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus
19	PMU1	YKL128C	469	n/a	chrXI 201,327	Putative phosphomutase, contains a region homologous to the active site of phosphomutases overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
20	SRO77	YBL106C	469	n/a	chrII 12,363	Protein with roles in exocytosis and cation homeostasis functions in docking and fusion of post-Golgi vesicles with plasma membrane homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor interacts with SNARE protein Sec9p
21	RPB11	YOL005C	469	n/a	chrXV 315,994	RNA polymerase II subunit B12.5 part of central core similar to Rpc19p and bacterial alpha subunit
22	CKB2	YOR039W	469	n/a	chrXV 406,156	Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
23	TAT2	YOL020W	469	n/a	chrXV 287,061	High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance
24	DRS2	YAL026C	469	n/a	chrI 97,663	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles contributes to clathrin-coated vesicle formation and endocytosis mutations in human homolog ATP8B1 result in liver disease
25	MBP1	YDL056W	469	n/a	chrIV 354,127	Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
26	BUR6	YER159C	469	n/a	chrV 491,744	Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription homologous to human NC2alpha
27	SER2	YGR208W	469	n/a	chrVII 912,347	Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
28	CKB1	YGL019W	469	n/a	chrVII 458,574	Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
29	SAC3	YDR159W	469	n/a	chrIV 773,829	Nuclear pore-associated protein required for biogenesis of the small ribosomal subunit component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
30	OST2	YOR103C	469	n/a	chrXV 516,645	Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
31	STB4	YMR019W	469	n/a	chrXIII 313,580	Protein that binds Sin3p in a two-hybrid assay contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins computational analysis suggests a role in regulation of expression of genes encoding transporters
32	YNL040W	YNL040W	469	n/a	chrXIV 554,065	Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm YNL040W is not an essential gene
33	SUB1	YMR039C	469	n/a	chrXIII 349,083	Transcriptional coactivator, facilitates elongation through factors that modify RNAP II role in peroxide resistance involving Rad2p role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes
34	TCB3	YML072C	469	n/a	chrXIII 127,048	Lipid-binding protein, localized to the bud via specific mRNA transport non-tagged protein detected in a phosphorylated state in mitochondria GFP-fusion protein localizes to the cell periphery C-termini of Tcb1p, Tcb2p and Tcb3p interact
35	PLP1	YDR183W	469	n/a	chrIV 829,931	Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding has weak similarity to phosducins, which are G-protein regulators
36	TRS120	YDR407C	469	n/a	chrIV 1,286,003	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion involved in endoplasmic reticulum (ER) to Golgi membrane traffic
37	VBA1	YMR088C	469	n/a	chrXIII 444,258	Permease of basic amino acids in the vacuolar membrane
38	PLB3	YOL011W	469	n/a	chrXV 306,379	Phospholipase B (lysophospholipase) involved in phospholipid metabolism hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
39	TLG2	YOL018C	469	n/a	chrXV 291,477	Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation homologous to mammalian SNARE protein syntaxin 16 (Sx16)
40	YAP7	YOL028C	469	n/a	chrXV 271,001	Putative basic leucine zipper (bZIP) transcription factor
41	NGL1	YOL042W	469	n/a	chrXV 250,370	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
42	LEA1	YPL213W	469	n/a	chrXVI 150,972	Component of U2 snRNP disruption causes reduced U2 snRNP levels physically interacts with Msl1p putative homolog of human U2A' snRNP protein
43	MDY2	YOL111C	469	n/a	chrXV 108,577	Protein with a role in insertion of tail-anchored proteins into the ER membrane forms a complex with Get4p required for efficient mating involved in shmoo formation and nuclear migration in the pre-zygote associates with ribosomes
44	RIB2	YOL066C	469	n/a	chrXV 203,583	Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs
45	NDJ1	YOL104C	469	n/a	chrXV 116,925	Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
46	ICT1	YLR099C	469	n/a	chrXII 340,336	Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress null displays increased sensitivity to Calcofluor white highly expressed during organic solvent stress
47	KCS1	YDR017C	469	n/a	chrIV 480,691	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
48	TRS33	YOR115C	469	n/a	chrXV 539,062	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion involved in endoplasmic reticulum (ER) to Golgi membrane traffic
49	YDL094C	YDL094C	469	n/a	chrIV 289,826	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data partially overlaps verfied gene PMT5/YDL093W YDL094C is not essential