UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	RSF1	YMR030W	361	n/a	chrXIII 331,358	Protein required for respiratory growth localized to both the nucleus and mitochondrion may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes
2	CDC37	YDR168W	361	n/a	chrIV 791,088	Essential Hsp90p co-chaperone necessary for passage through the START phase of the cell cycle stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
3	RAD2	YGR258C	361	n/a	chrVII 1,009,218	Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA subunit of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPG protein
4	BCY1	YIL033C	361	n/a	chrIX 291,044	Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
5	KIN1	YDR122W	361	n/a	chrIV 696,297	Serine/threonine protein kinase involved in regulation of exocytosis localizes to the cytoplasmic face of the plasma membrane closely related to Kin2p
6	SNA3	YJL151C	361	n/a	chrX 136,572	Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
7	RAD4	YER162C	361	0	chrV 501,762	Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair subunit of Nuclear Excision Repair Factor 2 (NEF2) also involved, with Rad23p, in turnover of ubiquitylated proteins
8	CMP2	YML057W	361	n/a	chrXIII 161,087	Calcineurin A one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
9	ART10	YLR392C	361	n/a	chrXII 905,527	Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p overexpression confers resistance to arsenite green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm non-essential gene
10	YMR31	YFR049W	361	n/a	chrVI 248,708	Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
11	MRS4	YKR052C	361	n/a	chrXI 533,007	Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane mitochondrial carrier family member, similar to and functionally redundant with Mrs3p active under low-iron conditions may transport other cations
12	RBK1	YCR036W	361	n/a	chrIII 193,797	Putative ribokinase
13	ADP1	YCR011C	361	n/a	chrIII 135,298	Putative ATP-dependent permease of the ABC transporter family of proteins
14	PBN1	YCL052C	361	n/a	chrIII 34,768	Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation homolog of mammalian PIG-X
15	COQ3	YOL096C	361	n/a	chrXV 138,576	O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis component of a mitochondrial ubiquinone-synthesizing complex phosphoprotein
16	YIM1	YMR152W	361	n/a	chrXIII 563,644	Protein of unknown function null mutant displays sensitivity to DNA damaging agents the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
17	MSP1	YGR028W	361	n/a	chrVII 542,747	Mitochondrial protein involved in sorting of proteins in the mitochondria putative membrane-spanning ATPase
18	RAD16	YBR114W	361	n/a	chrII 468,434	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
19	MLF3	YNL074C	361	n/a	chrXIV 487,445	Serine-rich protein of unknown function, predicted to be palmitoylated overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
20	YPS1	YLR120C	361	n/a	chrXII 387,365	Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
21	KNS1	YLL019C	361	n/a	chrXII 106,792	Nonessential putative protein kinase of unknown cellular role member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
22	DOA4	YDR069C	361	n/a	chrIV 586,329	Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
23	NGR1	YBR212W	361	n/a	chrII 648,895	RNA binding protein that negatively regulates growth rate interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation overexpression impairs mitochondrial function expressed in stationary phase
24	PPG1	YNR032W	361	n/a	chrXIV 686,563	Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation interacts with Tap42p, which binds to and regulates other protein phosphatases
25	PPZ2	YDR436W	361	n/a	chrIV 1,335,887	Serine/threonine protein phosphatase Z, isoform of Ppz1p involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
26	MNR2	YKL064W	361	n/a	chrXI 319,218	Vacuolar membrane protein required for magnesium homeostasis putative magnesium transporter has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
27	KKQ8	YKL168C	361	n/a	chrXI 132,375	Putative serine/threonine protein kinase with unknown cellular role
28	TUL1	YKL034W	361	n/a	chrXI 372,967	Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes
29	TGL4	YKR089C	361	n/a	chrXI 606,999	Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2 catalyzes acyl-CoA dependent acylation of LPA to PA required with Tgl3p for timely bud formation phosphorylated and activated by Cdc28p
30	MRPL24	YMR193W	361	n/a	chrXIII 650,424	Mitochondrial ribosomal protein of the large subunit
31	SCO2	YBR024W	361	n/a	chrII 289,897	Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase interacts with Cox2p
32	ECM21	YBL101C	361	n/a	chrII 26,622	Protein involved in regulating the endocytosis of plasma membrane proteins identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p promoter contains several Gcn4p binding elements
33	BSD2	YBR290W	361	n/a	chrII 783,073	Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
34	RIM11	YMR139W	361	n/a	chrXIII 546,681	Protein kinase required for signal transduction during entry into meiosis promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p shares similarity with mammalian glycogen synthase kinase 3-beta
35	RCK2	YLR248W	361	n/a	chrXII 635,168	Protein kinase involved in the response to oxidative and osmotic stress identified as suppressor of S. pombe cell cycle checkpoint mutations similar to CaM (calmodulin) kinases
36	ETP1	YHL010C	361	n/a	chrVIII 82,842	Putative protein of unknown function that is required for growth on ethanol contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
37	YHR113W	YHR113W	361	n/a	chrVIII 337,073	Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole CVT pathway cargo protein cleaves unblocked N-terminal acidic amino acids from peptide substrates forms a 12-subunit homo-oligomer M18 metalloprotease family
38	YAP1801	YHR161C	361	n/a	chrVIII 421,329	Protein involved in clathrin cage assembly binds Pan1p and clathrin homologous to Yap1802p, member of the AP180 protein family
39	NVJ1	YHR195W	361	n/a	chrVIII 491,229	Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
40	AIM18	YHR198C	361	n/a	chrVIII 496,797	Putative protein of unknown function the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies null mutant displays elevated frequency of mitochondrial genome loss
41	AIM46	YHR199C	361	n/a	chrVIII 497,956	Putative protein of unknown function the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies null mutant displays elevated frequency of mitochondrial genome loss
42	UIP3	YAR027W	361	n/a	chrI 184,123	Putative integral membrane protein of unknown function interacts with Ulp1p at the nuclear periphery member of DUP240 gene family
43	GID8	YMR135C	361	n/a	chrXIII 539,372	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase contains LisH and CTLH domains, like Vid30p dosage-dependent regulator of START
44	SIP5	YMR140W	361	n/a	chrXIII 548,448	Protein of unknown function interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase
45	ATG3	YNR007C	361	n/a	chrXIV 639,648	E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt
46	FMC1	YIL098C	361	n/a	chrIX 180,005	Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
47	YIR007W	YIR007W	361	n/a	chrIX 371,851	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm YIR007W is a non-essential gene
48	GLC8	YMR311C	361	n/a	chrXIII 897,258	Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation proposed to regulate Glc7p activity via conformational alteration ortholog of the mammalian protein phosphatase inhibitor 2
49	YFR045W	YFR045W	361	n/a	chrVI 242,498	Putative mitochondrial transport protein null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
50	BNA6	YFR047C	361	n/a	chrVI 244,722	Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine expression regulated by Hst1p