UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	GAL4	YPL248C	403	n/a	chrXVI 81,033	DNA-binding transcription factor required for the activation of the GAL genes in response to galactose repressed by Gal80p and activated by Gal3p
2	ARG81	YML099C	403	n/a	chrXIII 75,719	Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes acts with Arg80p and Arg82p
3	HAP2	YGL237C	403	n/a	chrVII 53,129	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression contains sequences sufficient for both complex assembly and DNA binding
4	STE7	YDL159W	403	n/a	chrIV 173,254	Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p phosphorylated by Ste11p, degraded by ubiquitin pathway
5	SPT2	YER161C	403	n/a	chrV 499,847	Protein involved in negative regulation of transcription required for RNA polyadenylation exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
6	HAP1	YLR256W	403	n/a	chrXII 648,669	Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
7	ABF1	YKL112W	403	n/a	chrXI 227,667	DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
8	MTF1	YMR228W	403	n/a	chrXIII 725,138	Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p
9	CDC23	YHR166C	403	0	chrVIII 438,110	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
10	SNF5	YBR289W	403	n/a	chrII 781,025	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation functions interdependently in transcriptional activation with Snf2p and Snf6p
11	GAL11	YOL051W	403	n/a	chrXV 236,562	Subunit of the RNA polymerase II mediator complex associates with core polymerase subunits to form the RNA polymerase II holoenzyme affects transcription by acting as target of activators and repressors forms part of the tail domain of mediator
12	DAL81	YIR023W	403	n/a	chrIX 401,233	Positive regulator of genes in multiple nitrogen degradation pathways contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
13	OPI1	YHL020C	403	n/a	chrVIII 66,849	Transcriptional regulator of a variety of genes phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes involved in telomere maintenance
14	SNF2	YOR290C	403	n/a	chrXV 857,702	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation contains DNA-stimulated ATPase activity functions interdependently in transcriptional activation with Snf5p and Snf6p
15	YCK1	YHR135C	403	n/a	chrVIII 373,502	Palmitoylated plasma membrane-bound casein kinase I isoform shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking provides an essential function overlapping with that of Yck2p
16	PEX1	YKL197C	403	n/a	chrXI 72,299	AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol induced by oleic acid and upregulated during anaerobiosis
17	ROX1	YPR065W	403	n/a	chrXVI 680,246	Heme-dependent repressor of hypoxic genes contains an HMG domain that is responsible for DNA bending activity
18	SWI4	YER111C	403	n/a	chrV 384,235	DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
19	SED4	YCR067C	403	n/a	chrIII 234,723	Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes binds Sec16p similar to Sec12p
20	PUT3	YKL015W	403	n/a	chrXI 410,013	Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state has a Zn(2)-Cys(6) binuclear cluster domain
21	HIR1	YBL008W	403	n/a	chrII 210,914	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
22	PET127	YOR017W	403	n/a	chrXV 362,613	Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane
23	STE5	YDR103W	403	n/a	chrIV 659,726	Pheromone-response scaffold protein that controls the mating decision binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p allosteric activator of Fus3p
24	IXR1	YKL032C	403	n/a	chrXI 380,961	Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA mediates aerobic transcriptional repression of COX5b
25	MKS1	YNL076W	403	n/a	chrXIV 484,433	Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation involved in retrograde (RTG) mitochondria-to-nucleus signaling
26	MOT2	YER068W	403	n/a	chrV 293,931	Subunit of the CCR4-NOT complex, which has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p
27	SPT23	YKL020C	403	n/a	chrXI 400,456	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
28	OAF3	YKR064W	403	n/a	chrXI 563,842	Zinc cluster protein regulates transcription in response to oleate levels the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
29	UBP14	YBR058C	403	n/a	chrII 354,844	Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains involved in fructose-1,6-bisphosphatase (Fbp1p) degradation similar to human isopeptidase T
30	MMS4	YBR098W	403	n/a	chrII 442,552	Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination
31	KIC1	YHR102W	403	n/a	chrVIII 318,193	Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall physically interacts with Cdc31p (centrin), which is a component of the spindle pole body
32	YAP3	YHL009C	403	n/a	chrVIII 84,564	Basic leucine zipper (bZIP) transcription factor
33	NAB3	YPL190C	403	n/a	chrXVI 186,521	Single stranded RNA binding protein acidic ribonucleoprotein required for termination of non-poly(A) transcripts and efficient splicing interacts with Nrd1p
34	FLO8	YER109C	403	n/a	chrV 376,414	Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth genome reference strain S288C and most laboratory strains have a mutation in this gene
35	HOS4	YIL112W	403	n/a	chrIX 153,220	Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity potential Cdc28p substrate
36	LYS14	YDR034C	403	n/a	chrIV 510,923	Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway requires 2-aminoadipate semialdehyde as co-inducer
37	CHA4	YLR098C	403	n/a	chrXII 338,500	DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1) Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
38	BRO1	YPL084W	403	n/a	chrXVI 395,305	Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
39	ZDS1	YMR273C	403	n/a	chrXIII 812,606	Protein with a role in regulating Swe1p-dependent polarized growth interacts with silencing proteins at the telomere has a role in Bcy1p localization implicated in mRNA nuclear export involved in mitotic exit through Cdc14p regulation
40	SNT2	YGL131C	403	n/a	chrVII 263,753	DNA binding protein with similarity to the S. pombe Snt2 protein computational analysis suggests a role in regulation of expression of genes encoding amine transporters
41	YGR012W	YGR012W	403	n/a	chrVII 513,749	Putative cysteine synthase, localized to the mitochondrial outer membrane
42	SNF12	YNR023W	403	n/a	chrXIV 671,268	73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation homolog of Rsc6p subunit of the RSC chromatin remodeling complex deletion mutants are temperature-sensitive
43	CRZ1	YNL027W	403	n/a	chrXIV 580,598	Transcription factor that activates transcription of genes involved in stress response nuclear localization is positively regulated by calcineurin-mediated dephosphorylation
44	MOT3	YMR070W	403	n/a	chrXIII 409,890	Nuclear transcription factor with two Cys2-His2 zinc fingers involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes can form the [MOT3+] prion
45	HPC2	YBR215W	403	n/a	chrII 654,336	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes
46	GCR2	YNL199C	403	n/a	chrXIV 265,728	Transcriptional activator of genes involved in glycolysis interacts and functions with the DNA-binding protein Gcr1p
47	RIM13	YMR154C	403	n/a	chrXIII 567,090	Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH has similarity to A. nidulans palB
48	UBX2	YML013W	403	n/a	chrXIII 245,026	Protein involved in ER-associated protein degradation proposed to coordinate the assembly of proteins involved in ERAD contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain
49	THI3	YDL080C	403	n/a	chrIV 311,556	Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols required for expression of enzymes involved in thiamine biosynthesis
50	ISW2	YOR304W	403	n/a	chrXV 886,195	ATP-dependent DNA translocase involved in chromatin remodeling ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth