UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	ECM12	YHR021W-A	571	n/a	chrVIII 149,452	Putative protein of unknown function may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
2	ADR1	YDR216W	571	n/a	chrIV 897,020	Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
3	YMR085W	YMR085W	571	n/a	chrXIII 438,140	Putative protein of unknown function YMR085W and adjacent ORF YMR084W are merged in related strains
4	KGD1	YIL125W	571	n/a	chrIX 124,211	Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
5	SSD1	YDR293C	571	n/a	chrIV 1,047,516	Translational repressor with a role in cell wall polar growth and integrity regulated by Cbk1p phosphorylation to effect bud-specific translational control of specific mRNAs interacts with TOR pathway components
6	MIG1	YGL035C	571	n/a	chrVII 432,305	Transcription factor involved in glucose repression sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs regulated by the SNF1 kinase and the GLC7 phosphatase
7	DLD1	YDL174C	571	n/a	chrIV 146,707	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate located in the mitochondrial inner membrane
8	NNK1	YKL171W	571	n/a	chrXI 128,868	Protein kinase implicated in proteasome function interacts with TORC1, Ure2 and Gdh2 overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3 epitope-tagged protein localizes to the cytoplasm
9	YKR096W	YKR096W	571	n/a	chrXI 628,586	Protein of unknown function that may interact with ribosomes, based on co-purification experiments green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm predicted to contain a PINc domain
10	FTH1	YBR207W	571	n/a	chrII 635,844	Putative high affinity iron transporter involved in transport of intravacuolar stores of iron forms complex with Fet5p expression is regulated by iron proposed to play indirect role in endocytosis
11	TPS3	YMR261C	571	n/a	chrXIII 791,787	Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose expression is induced by stress conditions and repressed by the Ras-cAMP pathway
12	KSP1	YHR082C	571	n/a	chrVIII 270,003	Ser/thr protein kinase nuclear translocation required for haploid filamentous growth regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p overproduction causes allele-specific suppression of prp20-10
13	VPS8	YAL002W	571	n/a	chrI 145,619	Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization component of the CORVET complex required for localization and trafficking of the CPY sorting receptor contains RING finger motif
14	GEM1	YAL048C	571	n/a	chrI 53,795	Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria not required for pheromone-induced cell death
15	YEL073C	YEL073C	571	n/a	chrV 7,391	Putative protein of unknown function located adjacent to ARS503 and the telomere on the left arm of chromosome V regulated by inositol/choline
16	ECM10	YEL030W	571	n/a	chrV 95,611	Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner overexpression induces extensive mitochondrial DNA aggregations
17	YEL020C	YEL020C	571	n/a	chrV 119,458	Hypothetical protein with low sequence identity to Pdc1p
18	ZRG8	YER033C	571	n/a	chrV 219,672	Protein of unknown function authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies GFP-fusion protein is localized to the cytoplasm transcription induced under conditions of zinc deficiency
19	RAD26	YJR035W	571	0	chrX 498,983	Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions recruitment to DNA lesions is dependent on an elongating RNA polymerase II homolog of human CSB protein
20	YJL070C	YJL070C	571	n/a	chrX 309,304	Putative protein of unknown function with similarity to AMP deaminases the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies YJL070C is a non-essential gene
21	YIL166C	YIL166C	571	n/a	chrIX 31,752	Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily mRNA expression is elevated by sulfur limitation YIL166C is a non-essential gene
22	VHR1	YIL056W	571	n/a	chrIX 250,952	Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
23	YIL055C	YIL055C	571	n/a	chrIX 252,983	Putative protein of unknown function
24	PKP1	YIL042C	571	n/a	chrIX 275,700	Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
25	YIR014W	YIR014W	571	n/a	chrIX 381,450	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the vacuole expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p YIR014W is a non-essential gene
26	HUL4	YJR036C	571	n/a	chrX 502,052	Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability
27	LST8	YNL006W	571	n/a	chrXIV 620,522	Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface component of the TOR signaling pathway associates with both Tor1p and Tor2p contains a WD-repeat
28	CUP9	YPL177C	571	n/a	chrXVI 213,502	Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
29	YGR205W	YGR205W	571	n/a	chrVII 909,649	ATP-binding protein of unknown function crystal structure resembles that of E.coli pantothenate kinase and other small kinases null mutant is sensitive to expression of the top1-T722A allele
30	RSF2	YJR127C	571	n/a	chrX 660,988	Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions
31	IML2	YJL082W	571	n/a	chrX 282,282	Protein of unknown function the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
32	YJR039W	YJR039W	571	n/a	chrX 505,618	Putative protein of unknown function the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
33	JSN1	YJR091C	571	n/a	chrX 596,698	Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins involved in localizing the Arp2/3 complex to mitochondria overexpression causes increased sensitivity to benomyl
34	YJR149W	YJR149W	571	n/a	chrX 707,767	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
35	SHE4	YOR035C	571	n/a	chrXV 398,919	Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
36	ROM1	YGR070W	571	n/a	chrVII 629,539	GDP/GTP exchange protein (GEP) for Rho1p mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
37	YOR1	YGR281W	571	n/a	chrVII 1,055,040	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin similar to human cystic fibrosis transmembrane receptor (CFTR)
38	IMA1	YGR287C	571	n/a	chrVII 1,068,106	Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization has specificity for isomaltose, palatinose, and methyl-alpha-glucoside member of the IMA isomaltase family
39	VEL1	YGL258W	571	n/a	chrVII 11,420	Protein of unknown function highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
40	FHN1	YGR131W	571	n/a	chrVII 754,988	Protein of unknown function induced by ketoconazole promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site overexpression complements function of Nce102p in NCE102 deletion strain
41	MAL13	YGR288W	571	n/a	chrVII 1,071,003	MAL-activator protein, part of complex locus MAL1 nonfunctional in genomic reference strain S288C
42	YPR003C	YPR003C	571	n/a	chrXVI 562,636	Putative sulfate permease physically interacts with Hsp82p green fluorescent protein (GFP)-fusion protein localizes to the ER YPR003C is not an essential gene
43	FPK1	YNR047W	571	n/a	chrXIV 709,863	Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p phosphorylates and inhibits upstream inhibitory kinase, Ypk1p localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane
44	CTF19	YPL018W	571	n/a	chrXVI 518,205	Outer kinetochore protein, required for accurate mitotic chromosome segregation component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
45	YMR279C	YMR279C	571	n/a	chrXIII 825,540	Putative boron transporter involved in boron efflux and resistance overexpression mutant but not null mutant displays boron tolerance phenotype identified as a heat-induced gene in a high-throughout screen YMR279C is not an essential gene paralog of the efflux pump ATR1
46	YMR160W	YMR160W	571	n/a	chrXIII 576,291	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole mutant has enhanced sensitivity to overexpression of mutant huntingtin YMR160W is not an essential gene
47	ARO80	YDR421W	571	n/a	chrIV 1,313,466	Zinc finger transcriptional activator of the Zn2Cys6 family activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
48	PDR15	YDR406W	571	n/a	chrIV 1,281,504	Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification regulated by Pdr1p, Pdr3p and Pdr8p promoter contains a PDR responsive element
49	XYL2	YLR070C	571	n/a	chrXII 274,676	Xylitol dehydrogenase, converts xylitol to D-xylulose expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae null mutant has cell wall defect
50	DNL4	YOR005C	571	n/a	chrXV 335,926	DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p involved in meiosis, not essential for vegetative growth