UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	COX5B	YIL111W	583	n/a	chrIX 155,493	Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth
2	PAI3	YMR174C	583	n/a	chrXIII 610,262	Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
3	PHR1	YOR386W	583	n/a	chrXV 1,067,687	DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light induced by DNA damage regulated by transcriptional repressor Rph1p
4	TPK2	YPL203W	583	n/a	chrXVI 166,827	cAMP-dependent protein kinase catalytic subunit promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway partially redundant with Tpk1p and Tpk3p localizes to P-bodies during stationary phase
5	GPH1	YPR160W	583	n/a	chrXVI 862,660	Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
6	CAR2	YLR438W	583	n/a	chrXII 1,013,138	L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process not nitrogen catabolite repression sensitive
7	PYC1	YGL062W	583	n/a	chrVII 386,964	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate highly similar to isoform Pyc2p but differentially regulated mutations in the human homolog are associated with lactic acidosis
8	ACO1	YLR304C	583	n/a	chrXII 736,380	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance phosphorylated component of the mitochondrial nucleoid mutation leads to glutamate auxotrophy
9	PDE1	YGL248W	583	n/a	chrVII 36,207	Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway glucose induces transcription and inhibits translation
10	CMK2	YOL016C	583	n/a	chrXV 295,448	Calmodulin-dependent protein kinase may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II
11	SIS1	YNL007C	583	n/a	chrXIV 619,036	Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p not functionally redundant with Ydj1p due to due to substrate specificity shares similarity with bacterial DnaJ proteins
12	IDH2	YOR136W	583	n/a	chrXV 580,804	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle phosphorylated
13	IDH1	YNL037C	583	n/a	chrXIV 558,461	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
14	PEP12	YOR036W	583	n/a	chrXV 400,781	Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment syntaxin
15	AFR1	YDR085C	583	n/a	chrIV 615,219	Protein required for pheromone-induced projection (shmoo) formation regulates septin architecture during mating has an RVXF motif that mediates targeting of Glc7p to mating projections interacts with Cdc12p
16	MSN4	YKL062W	583	n/a	chrXI 324,174	Transcriptional activator related to Msn2p activated in stress conditions, which results in translocation from the cytoplasm to the nucleus binds DNA at stress response elements of responsive genes, inducing gene expression
17	NTH2	YBR001C	583	n/a	chrII 240,112	Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses
18	MDJ1	YFL016C	583	n/a	chrVI 105,468	Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p involved in protein folding/refolding in the mitochodrial matrix required for proteolysis of misfolded proteins member of the HSP40 (DnaJ) family of chaperones
19	MRP8	YKL142W	583	n/a	chrXI 178,844	Protein of unknown function undergoes sumoylation transcription induced under cell wall stress protein levels are reduced under anaerobic conditions originally thought to be a mitochondrial ribosomal protein based on sequence analysis
20	YET1	YKL065C	583	n/a	chrXI 316,747	Endoplasmic reticulum transmembrane protein may interact with ribosomes, based on co-purification experiments homolog of human BAP31 protein
21	SDS22	YKL193C	583	n/a	chrXI 79,374	Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis
22	GPT2	YKR067W	583	n/a	chrXI 569,033	Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
23	SRL3	YKR091W	583	n/a	chrXI 611,895	Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation potential Cdc28p substrate
24	QCR10	YHR001W-A	583	n/a	chrVIII 107,974	Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
25	ETR1	YBR026C	583	n/a	chrII 293,448	2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family localized to in mitochondria, where it has a probable role in fatty acid synthesis
26	AGP2	YBR132C	583	n/a	chrII 500,547	High affinity polyamine permease, preferentially uses spermidine over putrescine expression is down-regulated by osmotic stress plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
27	ZTA1	YBR046C	583	n/a	chrII 331,009	NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin
28	CRG1	YHR209W	583	n/a	chrVIII 519,874	mRNA binding protein and putative S-adenosylmethionine-dependent methyltransferase mediates cantharidin resistance
29	BDH1	YAL060W	583	n/a	chrI 35,729	NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin enhances use of 2,3-butanediol as an aerobic carbon source
30	GIP2	YER054C	583	n/a	chrV 262,875	Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p
31	YER121W	YER121W	583	n/a	chrV 402,547	Putative protein of unknown function may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
32	XBP1	YIL101C	583	n/a	chrIX 176,278	Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2 expression is induced by stress or starvation during mitosis, and late in meiosis member of the Swi4p/Mbp1p family potential Cdc28p substrate
33	MET28	YIR017C	583	n/a	chrIX 383,837	Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
34	XKS1	YGR194C	583	n/a	chrVII 886,974	Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP rate limiting step in fermentation of xylulose required for xylose fermentation by recombinant S. cerevisiae strains
35	YFL054C	YFL054C	583	n/a	chrVI 21,817	Putative channel-like protein similar to Fps1p mediates passive diffusion of glycerol in the presence of ethanol
36	YFL042C	YFL042C	583	n/a	chrVI 46,732	Putative protein of unknown function YFL042C is not an essential gene
37	IKS1	YJL057C	583	n/a	chrX 329,119	Putative serine/threonine kinase expression is induced during mild heat stress deletion mutants are hypersensitive to copper sulphate and resistant to sorbate interacts with an N-terminal fragment of Sst2p
38	BAT2	YJR148W	583	n/a	chrX 706,309	Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism homolog of murine ECA39 highly expressed during stationary phase and repressed during logarithmic phase
39	GCV1	YDR019C	583	n/a	chrIV 484,764	T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
40	GLO1	YML004C	583	n/a	chrXIII 262,195	Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione expression regulated by methylglyoxal levels and osmotic stress
41	PYK2	YOR347C	583	n/a	chrXV 985,702	Pyruvate kinase that appears to be modulated by phosphorylation PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux
42	YPS5	YGL259W	583	n/a	chrVII 8,718	Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p
43	STR3	YGL184C	583	n/a	chrVII 155,313	Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine may be redox regulated by Gto1p
44	ATG1	YGL180W	583	n/a	chrVII 161,411	Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway structurally required for phagophore assembly site formation during autophagy forms a complex with Atg13p and Atg17p
45	LSC2	YGR244C	583	n/a	chrVII 978,677	Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
46	DAK1	YML070W	583	n/a	chrXIII 134,352	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA) involved in stress adaptation
47	TPS1	YBR126C	583	n/a	chrII 489,648	Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose also found in a monomeric form expression is induced by the stress response and repressed by the Ras-cAMP pathway
48	SED1	YDR077W	583	n/a	chrIV 601,301	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance ORF contains two distinct variable minisatellites
49	RPM2	YML091C	583	n/a	chrXIII 88,927	Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
50	RNY1	YPL123C	583	n/a	chrXVI 318,293	Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress promotes apoptosis under stress conditions and this function is independent of its catalytic activity