UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	PET54	YGR222W	379	n/a	chrVII 940,363	Mitochondrial inner membrane protein binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing
2	HSF1	YGL073W	379	n/a	chrVII 370,003	Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats posttranslationally regulated
3	CBS2	YDR197W	379	n/a	chrIV 851,812	Mitochondrial translational activator of the COB mRNA interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
4	DAP2	YHR028C	379	n/a	chrVIII 166,206	Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor localizes to the vacuolar membrane similar to Ste13p
5	VPS34	YLR240W	379	0	chrXII 618,846	Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting activated by the GTP-bound form of Gpa1p
6	MRPL25	YGR076C	379	n/a	chrVII 637,340	Mitochondrial ribosomal protein of the large subunit
7	STE11	YLR362W	379	n/a	chrXII 850,942	Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p regulated by Ste20p and Ste50p
8	CAD1	YDR423C	379	n/a	chrIV 1,318,660	AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance controls a set of genes involved in stabilizing proteins binds consensus sequence TTACTAA
9	CPR4	YCR069W	379	n/a	chrIII 239,533	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues has a potential role in the secretory pathway
10	YJU3	YKL094W	379	n/a	chrXI 263,819	Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
11	SNC1	YAL030W	379	n/a	chrI 87,519	Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane proposed to be involved in endocytosis member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
12	HYM1	YKL189W	379	n/a	chrXI 85,303	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
13	SEC17	YBL050W	379	n/a	chrII 125,622	Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy stimulates the ATPase activity of Sec18p has similarity to mammalian alpha-SNAP
14	YKU70	YMR284W	379	n/a	chrXIII 839,091	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
15	XRS2	YDR369C	379	n/a	chrIV 1,216,298	Protein required for DNA repair component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
16	SHP1	YBL058W	379	n/a	chrII 112,072	UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
17	VPS21	YOR089C	379	n/a	chrXV 490,512	Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases localized in endocytic intermediates detected in mitochondria geranylgeranylation required for membrane association mammalian Rab5 homolog
18	CBT1	YKL208W	379	n/a	chrXI 47,564	Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts may also have a role in 3' end processing of the COB pre-mRNA displays genetic interaction with cell cycle-regulated kinase Dbf2p
19	YKL023W	YKL023W	379	n/a	chrXI 394,137	Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
20	PDX3	YBR035C	379	n/a	chrII 306,612	Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus transcription is under the general control of nitrogen metabolism
21	TBS1	YBR150C	379	n/a	chrII 542,851	Putative protein of unknown function the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
22	TCM62	YBR044C	379	n/a	chrII 325,200	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex putative chaperone
23	UBX7	YBR273C	379	n/a	chrII 748,716	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
24	STB5	YHR178W	379	n/a	chrVIII 460,414	Transcription factor, involved in regulating multidrug resistance and oxidative stress response forms a heterodimer with Pdr1p contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro
25	APM2	YHL019C	379	n/a	chrVIII 68,639	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex involved in vesicular transport
26	DIA4	YHR011W	379	n/a	chrVIII 128,450	Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
27	OSH7	YHR001W	379	n/a	chrVIII 106,711	Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
28	NEM1	YHR004C	379	n/a	chrVIII 112,424	Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation homolog of the human protein Dullard
29	PET100	YDR079W	379	n/a	chrIV 603,231	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
30	AIM2	YAL049C	379	n/a	chrI 52,225	Cytoplasmic protein involved in mitochondrial function or organization null mutant displays reduced frequency of mitochondrial genome loss potential Hsp82p interactor
31	SNF7	YLR025W	379	n/a	chrXII 194,813	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III) involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway recruited from the cytoplasm to endosomal membranes
32	PEX17	YNL214W	379	n/a	chrXIV 245,916	Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins required for peroxisome biogenesis
33	OSW5	YMR148W	379	n/a	chrXIII 560,589	Protein of unknown function that may play a role in spore wall assembly predicted to contain an N-terminal transmembrane domain osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
34	CST6	YIL036W	379	n/a	chrIX 286,547	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, proposed to be a regulator of oleate responsive genes involved in utilization of non-optimal carbon sources and chromosome stability
35	YIR024C	YIR024C	379	n/a	chrIX 403,166	Protein of unknown function the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies interacts with Arh1p, a mitochondrial oxidoreductase deletion mutant has a respiratory growth defect
36	GTS1	YGL181W	379	n/a	chrVII 158,501	Protein involved in Arf3p regulation and in transcription regulation localizes to the nucleus and to endocytic patches contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis expression oscillates in a pattern similar to metabolic oscillations
37	PHB1	YGR132C	379	n/a	chrVII 756,020	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins determinant of replicative life span involved in mitochondrial segregation
38	GUF1	YLR289W	379	n/a	chrXII 716,057	Mitochondrial matrix GTPase that associates with mitochondrial ribosomes important for translation under temperature and nutrient stress may have a role in translational fidelity similar to bacterial LepA elongation factor
39	DAS1	YJL149W	379	n/a	chrX 138,374	Putative SCF ubiquitin ligase F-box protein interacts physically with both Cdc53p and Skp1 and genetically with CDC34 similar to putative F-box protein YDR131C
40	YJL055W	YJL055W	379	n/a	chrX 333,725	Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues deletion mutants are sensitive to HAP and AHA overexpression confers resistance to 5-FOA and 5-FU
41	AIM25	YJR100C	379	n/a	chrX 616,842	Putative protein of unknown function non-tagged protein is detected in purified mitochondria in high-throughput studies similar to murine NOR1 null mutant is viable and displays elevated frequency of mitochondrial genome loss
42	SSN8	YNL025C	379	n/a	chrXIV 584,805	Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain involved in glucose repression and telomere maintenance
43	AIM37	YNL100W	379	n/a	chrXIV 437,965	Putative protein of unknown function non-tagged protein is detected in purified mitochondria null mutant is viable and displays reduced respiratory growth and reduced frequency of mitochondrial genome loss
44	VID30	YGL227W	379	n/a	chrVII 71,109	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase) binds FBPase shifts the balance of nitrogen metabolism toward glutamate production localizes to the nucleus and the cytoplasm
45	MDM34	YGL219C	379	n/a	chrVII 83,567	Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
46	DSD1	YGL196W	379	n/a	chrVII 130,526	D-serine dehydratase (aka D-serine ammonia-lyase) converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc may play a role in D-serine detoxification L-serine is not a substrate
47	YGL185C	YGL185C	379	n/a	chrVII 153,736	Putative protein with sequence similarity to hydroxyacid dehydrogenases green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
48	PEX14	YGL153W	379	n/a	chrVII 216,785	Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p
49	PRM8	YGL053W	379	n/a	chrVII 402,945	Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding forms a complex with Prp9p in the ER member of DUP240 gene family
50	JAC1	YGL018C	379	n/a	chrVII 459,387	Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism contains a J domain typical to J-type chaperones localizes to the mitochondrial matrix