UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	PIS1	YPR113W	367	n/a	chrXVI 752,588	Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
2	ALG7	YBR243C	367	n/a	chrII 706,120	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation inhibited by tunicamycin
3	SPE1	YKL184W	367	n/a	chrXI 97,457	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis degraded in a proteasome-dependent manner in the presence of excess polyamines deletion decreases lifespan, and increases necrotic cell death and ROS generation
4	ARF1	YDL192W	367	n/a	chrIV 116,593	ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi functionally interchangeable with Arf2p
5	TCP1	YDR212W	367	n/a	chrIV 888,071	Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol involved in actin cytoskeleton maintenance overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
6	NMT1	YLR195C	367	n/a	chrXII 542,620	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
7	PHO13	YDL236W	367	n/a	chrIV 32,765	Alkaline phosphatase specific for p-nitrophenyl phosphate also has protein phosphatase activity
8	SAR1	YPL218W	367	n/a	chrXVI 139,053	GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles required for transport vesicle formation during ER to Golgi protein transport
9	MCK1	YNL307C	367	n/a	chrXIV 57,009	Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis related to mammalian glycogen synthase kinases of the GSK-3 family
10	TRX1	YLR043C	367	n/a	chrXII 231,857	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance
11	TOM40	YMR203W	367	n/a	chrXIII 669,073	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins constitutes the core element of the protein conducting pore
12	ERG4	YGL012W	367	n/a	chrVII 473,565	C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis mutants are viable, but lack ergosterol
13	VMA3	YEL027W	367	n/a	chrV 101,010	Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c dicyclohexylcarbodiimide binding subunit) required for vacuolar acidification and important for copper and iron metal ion homeostasis
14	ITR2	YOL103W	367	n/a	chrXV 124,915	Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily expressed constitutively
15	EMP24	YGL200C	367	n/a	chrVII 122,999	Component of the p24 complex binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
16	SLC1	YDL052C	367	n/a	chrIV 363,127	1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism enzymatic activity detected in lipid particles and microsomes
17	PGM1	YKL127W	367	n/a	chrXI 204,397	Phosphoglucomutase, minor isoform catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
18	SEC66	YBR171W	367	n/a	chrII 578,674	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p) with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
19	WBP1	YEL002C	367	n/a	chrV 149,368	Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex required for N-linked glycosylation of proteins in the endoplasmic reticulum
20	YBL055C	YBL055C	367	n/a	chrII 116,201	3'-->5' exonuclease and endonuclease with a possible role in apoptosis has similarity to mammalian and C. elegans apoptotic nucleases
21	KES1	YPL145C	367	n/a	chrXVI 279,047	Member of the oxysterol binding protein family, which includes seven yeast homologs involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex
22	KTR3	YBR205W	367	n/a	chrII 634,229	Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family Svp26p mediates uptake of Ktr3p into COPII vesicles
23	ERV15	YBR210W	367	n/a	chrII 645,764	Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
24	LAG1	YHL003C	367	n/a	chrVIII 101,265	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
25	CHS7	YHR142W	367	n/a	chrVIII 384,013	Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
26	GAA1	YLR088W	367	n/a	chrXII 317,029	Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER
27	SOP4	YJL192C	367	n/a	chrX 73,062	ER-membrane protein suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER
28	ERP2	YAL007C	367	n/a	chrI 138,021	Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
29	ALG8	YOR067C	367	n/a	chrXV 452,595	Glucosyl transferase, involved in N-linked glycosylation adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis similar to Alg6p
30	PAN6	YIL145C	367	n/a	chrIX 76,818	Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
31	APQ12	YIL040W	367	n/a	chrIX 277,931	Protein required for nuclear envelope morphology, nuclear pore complex localization, mRNA export from the nucleus exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism
32	TED1	YIL039W	367	n/a	chrIX 279,136	Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
33	PHS1	YJL097W	367	n/a	chrX 245,917	Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids evolutionarily conserved, similar to mammalian PTPLA and PTPLB involved in sphingolipid biosynthesis and protein trafficking
34	PMP2	YEL017C-A	367	n/a	chrV 122,863	Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p) regulates plasma membrane H(+)-ATPase activity nearly identical to PMP1
35	GAB1	YLR459W	367	n/a	chrXII 1,057,926	GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins may have a role in recognition of the attachment signal or of the lipid portion of GPI
36	VMA21	YGR105W	367	n/a	chrVII 698,715	Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex functions in the assembly of the V-ATPase localized to the yeast endoplasmic reticulum (ER)
37	MID1	YNL291C	367	n/a	chrXIV 84,992	N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone interacts with Cch1p forms an oligomer
38	PHO86	YJL117W	367	n/a	chrX 192,998	Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles
39	AVT1	YJR001W	367	n/a	chrX 437,706	Vacuolar transporter, imports large neutral amino acids into the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
40	OST3	YOR085W	367	n/a	chrXV 482,559	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Ost3p is important for N-glycosylation of a subset of proteins
41	YIP1	YGR172C	367	n/a	chrVII 843,218	Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles interacts with Yif1p and Yos1p localizes to the Golgi, the ER, and COPII vesicles homolog of human YIPF4
42	NPY1	YGL067W	367	n/a	chrVII 376,678	NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides localizes to peroxisomes
43	YGL039W	YGL039W	367	n/a	chrVII 424,484	Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols
44	ERG26	YGL001C	367	n/a	chrVII 495,977	C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
45	VOA1	YGR106C	367	n/a	chrVII 699,387	Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase) null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
46	TOM7	YNL070W	367	n/a	chrXIV 493,457	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins promotes assembly and stability of the TOM complex
47	ALG9	YNL219C	367	n/a	chrXIV 236,829	Mannosyltransferase, involved in N-linked glycosylation catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides mutation of the human ortholog causes type 1 congenital disorders of glycosylation
48	ACT1	YFL039C	367	n/a	chrVI 53,978	Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
49	SWP1	YMR149W	367	n/a	chrXIII 561,426	Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
50	OST6	YML019W	367	n/a	chrXIII 233,956	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins similar to and partially functionally redundant with Ost3p