UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	STE2	YFL026W	541	n/a	chrVI 83,227	Receptor for alpha-factor pheromone seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
2	HXK2	YGL253W	541	n/a	chrVII 24,665	Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol predominant hexokinase during growth on glucose functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
3	FUS1	YCL027W	541	n/a	chrIII 72,572	Membrane protein localized to the shmoo tip, required for cell fusion expression regulated by mating pheromone proposed to coordinate signaling, fusion, and polarization events required for fusion potential Cdc28p substrate
4	SST2	YLR452C	541	n/a	chrXII 1,040,318	GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone also required to prevent receptor-independent signaling of the mating pathway member of the RGS (regulator of G-protein signaling) family
5	BAR1	YIL015W	541	n/a	chrIX 323,223	Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
6	RSR1	YGR152C	541	n/a	chrVII 795,083	GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion localized to the plasma membrane significantly similar to mammalian Rap GTPases
7	URA4	YLR420W	541	n/a	chrXII 964,332	Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
8	SEC62	YPL094C	541	n/a	chrXVI 370,251	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p) with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
9	EXG1	YLR300W	541	n/a	chrXII 729,628	Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly exists as three differentially glycosylated isoenzymes
10	CLB1	YGR108W	541	n/a	chrVII 704,343	B-type cyclin involved in cell cycle progression activates Cdc28p to promote the transition from G2 to M phase accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
11	ERG6	YML008C	541	n/a	chrXIII 252,414	Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24 localized to both lipid particles and mitochondrial outer membrane
12	PMI40	YER003C	541	n/a	chrV 158,427	Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P required for early steps in protein mannosylation
13	AGA1	YNR044W	541	n/a	chrXIV 704,787	Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
14	ERG2	YMR202W	541	3e-130	chrXIII 667,871	C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
15	SEC61	YLR378C	541	n/a	chrXII 876,457	Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p) forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER with Sec63 complex allows SRP-independent protein import into ER
16	MFA1	YDR461W	541	n/a	chrIV 1,385,231	Mating pheromone a-factor, made by a cells interacts with alpha cells to induce cell cycle arrest and other responses leading to mating biogenesis involves C-terminal modification, N-terminal proteolysis, and export also encoded by MFA2
17	MFA2	YNL145W	541	n/a	chrXIV 352,472	Mating pheromone a-factor, made by a cells interacts with alpha cells to induce cell cycle arrest and other responses leading to mating biogenesis involves C-terminal modification, N-terminal proteolysis, and export also encoded by MFA1
18	PRY2	YKR013W	541	n/a	chrXI 464,453	Protein of unknown function
19	UTH1	YKR042W	541	n/a	chrXI 520,075	Mitochondrial outer membrane and cell wall localized SUN family member involved in cell wall biogenesis and required for mitochondrial autophagy involved in the oxidative stress response, life span during starvation, and cell death
20	ECM33	YBR078W	541	n/a	chrII 393,932	GPI-anchored protein of unknown function, has a possible role in apical bud growth GPI-anchoring on the plasma membrane crucial to function phosphorylated in mitochondria similar to Sps2p and Pst1p
21	TOS1	YBR162C	541	n/a	chrII 563,886	Covalently-bound cell wall protein of unknown function identified as a cell cycle regulated SBF target gene deletion mutants are highly resistant to treatment with beta-1,3-glucanase has sequence similarity to YJL171C
22	DSE2	YHR143W	541	n/a	chrVIII 385,998	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother expression is repressed by cAMP
23	EGD2	YHR193C	541	n/a	chrVIII 487,974	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
24	BFR1	YOR198C	541	n/a	chrXV 719,359	Component of mRNP complexes associated with polyribosomes implicated in secretion and nuclear segregation multicopy suppressor of BFA (Brefeldin A) sensitivity
25	ERG10	YPL028W	541	n/a	chrXVI 498,694	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA involved in the first step in mevalonate biosynthesis
26	PSA1	YDL055C	541	n/a	chrIV 356,216	GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis required for normal cell wall structure
27	GCN20	YFR009W	541	n/a	chrVI 163,617	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p proposed to stimulate Gcn2p activation by an uncharged tRNA
28	CIS3	YJL158C	541	n/a	chrX 122,606	Mannose-containing glycoprotein constituent of the cell wall member of the PIR (proteins with internal repeats) family
29	ADO1	YJR105W	541	n/a	chrX 624,092	Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet) may be involved in recycling adenosine produced through the methyl cycle
30	PPT1	YGR123C	541	n/a	chrVII 737,432	Protein serine/threonine phosphatase with similarity to human phosphatase PP5 present in both the nucleus and cytoplasm expressed during logarithmic growth computational analyses suggest roles in phosphate metabolism and rRNA processing
31	ARO8	YGL202W	541	n/a	chrVII 116,810	Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
32	YIP3	YNL044W	541	n/a	chrXIV 545,572	Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport interacts with members of the Rab GTPase family and Yip1p also interacts with Rtn1p
33	ERG13	YML126C	541	n/a	chrXIII 19,797	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA involved in the second step in mevalonate biosynthesis
34	SCW10	YMR305C	541	n/a	chrXIII 879,647	Cell wall protein with similarity to glucanases may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
35	YLR179C	YLR179C	541	n/a	chrXII 514,410	Protein of unknown function with similarity to Tfs1p transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance GFP-tagged protein localizes to the cytoplasm and nucleus
36	ABP140	YOR239W	541	n/a	chrXV 785,800	AdoMet-dependent tRNA methyltransferase and actin binding protein C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift
37	SRL1	YOR247W	541	n/a	chrXV 797,992	Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins has a high serine-threonine content expression is induced in cell wall mutants
38	SVS1	YPL163C	541	n/a	chrXVI 242,309	Cell wall and vacuolar protein, required for wild-type resistance to vanadate