UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	CDC36	YDL165W	535	n/a	chrIV 164,577	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation basal transcription factor
2	CBP1	YJL209W	535	n/a	chrX 38,987	Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation found in a complex at the inner membrane along with Pet309p
3	ERG12	YMR208W	535	n/a	chrXIII 685,132	Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
4	CKA1	YIL035C	535	n/a	chrIX 288,349	Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
5	VMA2	YBR127C	535	n/a	chrII 492,045	Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system contains nucleotide binding sites also detected in the cytoplasm
6	TYR1	YBR166C	535	n/a	chrII 570,521	Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels
7	SLY1	YDR189W	535	n/a	chrIV 839,392	Hydrophilic protein involved in vesicle trafficking between the ER and Golgi SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
8	APN1	YKL114C	535	n/a	chrXI 223,903	Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
9	ERG8	YMR220W	535	n/a	chrXIII 712,993	Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
10	YCR090C	YCR090C	535	n/a	chrIII 272,589	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus YCR090C is not an essential gene
11	VPH2	YKL119C	535	n/a	chrXI 218,893	Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex functions in the assembly of the V-ATPase localized to the endoplasmic reticulum (ER)
12	CDC11	YJR076C	535	n/a	chrX 575,977	Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
13	ERG24	YNL280C	535	n/a	chrXIV 109,753	C-14 sterol reductase, acts in ergosterol biosynthesis mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
14	ECM25	YJL201W	535	n/a	chrX 55,278	Non-essential protein of unknown function promoter contains a consensus binding sequence for factor Abf1p
15	STE14	YDR410C	535	n/a	chrIV 1,292,731	Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane
16	HBS1	YKR084C	535	n/a	chrXI 597,972	GTPase with similarity to translation release factors together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled genetically implicated in mRNA no-go decay
17	NPL6	YMR091C	535	n/a	chrXIII 450,711	Component of the RSC chromatin remodeling complex interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions involved in nuclear protein import and maintenance of proper telomere length
18	KRE11	YGR166W	535	n/a	chrVII 831,356	Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi role in cell wall beta-glucan biosynthesis and the stress response
19	BUD2	YKL092C	535	n/a	chrXI 267,802	GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns mutants exhibit random budding in all cell types
20	ARL1	YBR164C	535	n/a	chrII 568,150	Soluble GTPase with a role in regulation of membrane traffic regulates potassium influx G protein of the Ras superfamily, similar to ADP-ribosylation factor
21	APM3	YBR288C	535	n/a	chrII 778,737	Mu3-like subunit of the clathrin associated protein complex (AP-3) functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
22	YBL036C	YBL036C	535	n/a	chrII 150,833	Putative non-specific single-domain racemase based on structural similarity binds pyridoxal 5'-phosphate expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
23	RFC5	YBR087W	535	n/a	chrII 424,297	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
24	GLO3	YER122C	535	n/a	chrV 403,611	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport shares functional similarity with Gcs1p
25	SRP14	YDL092W	535	n/a	chrIV 293,001	Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting homolog of mammalian SRP14
26	RCY1	YJL204C	535	n/a	chrX 51,890	F-box protein involved in recycling plasma membrane proteins internalized by endocytosis localized to sites of polarized growth
27	SEC72	YLR292C	535	n/a	chrXII 720,079	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p) with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
28	AGE2	YIL044C	535	n/a	chrIX 273,398	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport contains C2C2H2 cysteine/histidine motif
29	KRE27	YIL027C	535	n/a	chrIX 303,891	Member of a transmembrane complex required for efficient folding of proteins in the ER null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance
30	IOC3	YFR013W	535	n/a	chrVI 171,103	Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome has homology to Esc8p, which is involved in silencing
31	HOC1	YJR075W	535	n/a	chrX 574,576	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p identified as a suppressor of a cell lysis sensitive pkc1-371 allele
32	NUP57	YGR119C	535	n/a	chrVII 728,858	Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p
33	TAF4	YMR005W	535	n/a	chrXIII 276,628	TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation potential Cdc28p substrate
34	ORC5	YNL261W	535	n/a	chrXIV 155,819	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
35	OCA1	YNL099C	535	n/a	chrXIV 438,925	Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA
36	FOL2	YGR267C	535	n/a	chrVII 1,025,369	GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
37	UBA2	YDR390C	535	n/a	chrIV 1,255,892	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting essential for viability
38	SCY1	YGL083W	535	n/a	chrVII 354,265	Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
39	TAF6	YGL112C	535	n/a	chrVII 298,953	Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
40	TAN1	YGL232W	535	n/a	chrVII 62,538	Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA
41	EMC4	YGL231C	535	n/a	chrVII 63,334	Member of a transmembrane complex required for efficient folding of proteins in the ER null mutant displays induction of the unfolded protein response human ortholog TMEM85 may function in apoptosis
42	SDT1	YGL224C	535	n/a	chrVII 78,436	Pyrimidine nucleotidase overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
43	TYW3	YGL050W	535	n/a	chrVII 406,186	tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
44	GET1	YGL020C	535	n/a	chrVII 457,516	Subunit of the GET complex involved in insertion of proteins into the ER membrane required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
45	COG6	YNL041C	535	0	chrXIV 550,727	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
46	KTR6	YPL053C	535	n/a	chrXVI 457,788	Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway member of the KRE2/MNT1 mannosyltransferase family
47	SED5	YLR026C	535	n/a	chrXII 195,961	cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
48	SKO1	YNL167C	535	n/a	chrXIV 320,387	Basic leucine zipper transcription factor of the ATF/CREB family forms a complex with Tup1p and Cyc8p to both activate and repress transcription cytosolic and nuclear protein involved in osmotic and oxidative stress responses
49	RSC4	YKR008W	535	n/a	chrXI 453,139	Component of the RSC chromatin remodeling complex found in close proximity to nucleosomal DNA displaced from the surface of nucleosomal DNA after chromatin remodeling acetylated (K25) by Gcn5p, altering replication stress tolerance contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
50	GRX3	YDR098C	535	n/a	chrIV 644,606	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase monothiol glutaredoxin subfamily member along with Grx4p and Grx5p protects cells from oxidative damage