UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	PDR1	YGL013C	421	n/a	chrVII 470,695	Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes
2	YPK1	YKL126W	421	n/a	chrXI 206,728	Serine/threonine protein kinase that phosphorylates and downregulates flippase activator Fpk1p mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways homolog of mammalian kinase SGK
3	SNF4	YGL115W	421	n/a	chrVII 292,517	Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member) activates glucose-repressed genes, represses glucose-induced genes role in sporulation, and peroxisome biogenesis
4	PRE1	YER012W	421	0.00000005	chrV 178,133	Beta 4 subunit of the 20S proteasome localizes to the nucleus throughout the cell cycle
5	PUP1	YOR157C	421	1e-149	chrXV 631,358	Beta 2 subunit of the 20S proteasome endopeptidase with trypsin-like activity that cleaves after basic residues synthesized as a proprotein before being proteolytically processed for assembly into 20S particle human homolog is subunit Z
6	CNB1	YKL190W	421	n/a	chrXI 83,248	Calcineurin B the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1
7	ARP2	YDL029W	421	n/a	chrIV 399,989	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity
8	RPN12	YFR052W	421	n/a	chrVI 252,917	Subunit of the 19S regulatory particle of the 26S proteasome lid synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle physically interacts with Nob1p and Rpn3p
9	RPT5	YOR117W	421	n/a	chrXV 545,681	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates recruited to the GAL1-10 promoter region upon induction of transcription similar to human TBP1
10	PTC3	YBL056W	421	n/a	chrII 114,465	Type 2C protein phosphatase (PP2C) dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p) role in DNA damage checkpoint inactivation
11	YKT6	YKL196C	421	n/a	chrXI 75,233	Vesicle membrane protein (v-SNARE) with acyltransferase activity involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion membrane localization due to prenylation at the carboxy-terminus
12	PRE3	YJL001W	421	2e-21	chrX 435,544	Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
13	END3	YNL084C	421	n/a	chrXIV 470,577	EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis forms a complex with Sla1p and Pan1p
14	LTP1	YPR073C	421	n/a	chrXVI 692,175	Protein phosphotyrosine phosphatase of unknown cellular role activated by adenine
15	ARC15	YIL062C	421	n/a	chrIX 244,230	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches has mRNA binding activity
16	DOT5	YIL010W	421	n/a	chrIX 335,205	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
17	RBL2	YOR265W	421	n/a	chrXV 820,614	Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin proposed to be involved the folding of beta-tubulin similar to mouse beta-tubulin cofactor A
18	YGR266W	YGR266W	421	n/a	chrVII 1,023,708	Protein of unknown function, predicted to contain a single transmembrane domain mutant has increased aneuploidy tolerance localized to both the mitochondrial outer membrane and the plasma membrane
19	UBX4	YMR067C	421	n/a	chrXIII 404,948	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
20	YMR099C	YMR099C	421	n/a	chrXIII 464,380	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
21	RPN9	YDR427W	421	n/a	chrIV 1,322,795	Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects
22	GYL1	YMR192W	421	n/a	chrXIII 648,199	Putative GTPase activating protein (GAP) with a role in exocytosis stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth interacts with Gyp5p, Rvs161p, and Rvs167p involved in recruiting Rvs167p to the bud tip during polarized growth
23	GAL83	YER027C	421	n/a	chrV 209,605	One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source contains glycogen-binding domain
24	BCH1	YMR237W	421	n/a	chrXIII 744,836	Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane may interact with ribosomes
25	RPN7	YPR108W	421	n/a	chrXVI 743,098	Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits
26	CTS2	YDR371W	421	n/a	chrIV 1,220,180	Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
27	REH1	YLR387C	421	n/a	chrXII 897,023	Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation contains dispersed C2H2 zinc finger domains
28	SNX3	YOR357C	421	n/a	chrXV 1,009,468	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment contains a PX domain and sequence similarity to human Snx3p
29	SMT3	YDR510W	421	n/a	chrIV 1,469,552	Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics phosphorylated at Ser2
30	RDI1	YDL135C	421	n/a	chrIV 218,984	Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p and Rho1p
31	APM4	YOL062C	421	n/a	chrXV 211,257	Mu2-like subunit of the clathrin associated protein complex (AP-2) involved in vesicle transport