UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	PHO2	YDL106C	529	n/a	chrIV 271,061	Homeobox transcription factor regulatory targets include genes involved in phosphate metabolism binds cooperatively with Pho4p to the PHO5 promoter phosphorylation of Pho2p facilitates interaction with Pho4p
2	PHO4	YFR034C	529	n/a	chrVI 225,489	Basic helix-loop-helix (bHLH) transcription factor of the myc-family activates transcription cooperatively with Pho2p in response to phosphate limitation binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p, function is regulated by phosphorylation at multiple sites and by phosphate availability
3	YOR302W	YOR302W	529	n/a	chrXV 882,803	CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA
4	MUC1	YIR019C	529	n/a	chrIX 391,623	GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)
5	SWI1	YPL016W	529	n/a	chrXVI 522,986	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2 can form the prion [SWI+]
6	SFL1	YOR140W	529	n/a	chrXV 588,131	Transcriptional repressor and activator involved in repression of flocculation-related genes, and activation of stress responsive genes negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
7	SPO11	YHL022C	529	n/a	chrVIII 63,559	Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction required for homologous chromosome pairing and synaptonemal complex formation
8	SPO13	YHR014W	529	n/a	chrVIII 132,484	Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
9	RER1	YCL001W	529	n/a	chrIII 112,199	Protein involved in retention of membrane proteins, including Sec12p, in the ER localized to Golgi functions as a retrieval receptor in returning membrane proteins to the ER
10	YCL073C	YCL073C	529	n/a	chrIII 7,402	Proton:glutathione antiporter localized to the vacuolar and plasma membranes imports glutathione from the vacuole and exports it through the plasma membrane has a role in resistance to oxidative stress and modulation of the PKA pathway
11	RIF1	YBR275C	529	n/a	chrII 754,231	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing deletion results in telomere elongation
12	HXT3	YDR345C	529	n/a	chrIV 1,163,808	Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
13	NIP100	YPL174C	529	n/a	chrXVI 221,470	Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells putative ortholog of mammalian p150(glued)
14	MSN2	YMR037C	529	n/a	chrXIII 345,460	Transcriptional activator related to Msn4p activated in stress conditions, which results in translocation from the cytoplasm to the nucleus binds DNA at stress response elements of responsive genes, inducing gene expression
15	GIP1	YBR045C	529	n/a	chrII 329,132	Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
16	RCK1	YGL158W	529	n/a	chrVII 207,802	Protein kinase involved in the response to oxidative stress identified as suppressor of S. pombe cell cycle checkpoint mutations
17	ARN1	YHL040C	529	n/a	chrVIII 20,029	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
18	RTT107	YHR154W	529	n/a	chrVIII 404,572	Protein implicated in Mms22-dependent DNA repair during S phase involved in recruiting the SMC5/6 complex to double-strand breaks DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs interacts with Mms22p and Slx4p has four BRCT domains has a role in regulation of Ty1 transposition
19	GDH3	YAL062W	529	n/a	chrI 32,253	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate rate of alpha-ketoglutarate utilization differs from Gdh1p expression regulated by nitrogen and carbon sources
20	OAF1	YAL051W	529	n/a	chrI 50,135	Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
21	YER130C	YER130C	529	n/a	chrV 421,780	Protein of unknown function transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators the C. Albicans homolog (MNL1) plays a role in adaptation to stress
22	YTA6	YPL074W	529	n/a	chrXVI 416,895	Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells
23	HAC1	YFL031W	529	n/a	chrVI 75,663	Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis ER stress-induced splicing pathway facilitates efficient Hac1p synthesis
24	SHR5	YOL110W	529	n/a	chrXV 109,532	Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage palmitoylation is required for Ras2p membrane localization
25	ZAP1	YJL056C	529	n/a	chrX 331,752	Zinc-regulated transcription factor binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc regulates its own transcription contains seven zinc-finger domains
26	ASK10	YGR097W	529	n/a	chrVII 680,415	Component of RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress has a role in destruction of Ssn8p proposed to function in activation of the glycerol channel Fps1p paralogous to Rgc1p
27	PSP2	YML017W	529	0	chrXIII 237,659	Asn rich cytoplasmic protein that contains RGG motifs high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha) possible role in mitochondrial mRNA splicing
28	SOK2	YMR016C	529	n/a	chrXIII 304,414	Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway negatively regulates pseudohyphal differentiation homologous to several transcription factors
29	THO2	YNL139C	529	n/a	chrXIV 363,320	Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination required for LacZ RNA expression from certain plasmids
30	BIO4	YNR057C	529	n/a	chrXIV 733,712	Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis expression appears to be repressed at low iron levels
31	ATG2	YNL242W	529	n/a	chrXIV 193,713	Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway involved in Atg9p cycling between the phagophore assembly site and mitochondria
32	ULP1	YPL020C	529	n/a	chrXVI 513,245	Protease that specifically cleaves Smt3p protein conjugates required for cell cycle progression associates with nucleoporins and may interact with septin rings during telophase sequestered to the nucleolus under stress conditions
33	IRC15	YPL017C	529	n/a	chrXVI 519,483	Microtubule associated protein regulates microtubule dynamics required for accurate meiotic chromosome segregation null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
34	UME1	YPL139C	529	n/a	chrXVI 290,360	Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif homologous with Wtm1p, Wtm2p
35	ECM5	YMR176W	529	n/a	chrXIII 613,857	Non-essential protein of unknown function, contains ATP/GTP-binding site motif A null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks
36	WAR1	YML076C	529	n/a	chrXIII 113,930	Homodimeric Zn2Cys6 zinc finger transcription factor binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
37	SCC2	YDR180W	529	n/a	chrIV 823,535	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes involved in establishing sister chromatid cohesion during DSB repair via histone H2AX evolutionarily-conserved adherin
38	CDA2	YLR308W	529	n/a	chrXII 748,406	Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan required for proper rigidity of the ascospore wall
39	YOR378W	YOR378W	529	n/a	chrXV 1,050,284	Putative paralog of ATR1, but not required for boron tolerance member of the DHA2 family of drug:H+ antiporters YOR378W is not an essential gene
40	YDL109C	YDL109C	529	n/a	chrIV 266,229	Putative lipase involved in lipid metabolism YDL109C is not an essential gene
41	RLM1	YPL089C	529	n/a	chrXVI 380,135	MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity phosphorylated and activated by the MAP-kinase Slt2p
42	DNF3	YMR162C	529	n/a	chrXIII 581,436	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles localizes to the trans-Golgi network likely involved in protein transport type 4 P-type ATPase
43	YKL044W	YKL044W	529	n/a	chrXI 356,482	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data