UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	fzo-1	ZK1248.14	0	chrII 5,834,733	C. elegans FZO-1 protein; contains similarity to Pfam domain PF04799 fzo-like conserved region contains similarity to Interpro domains IPR006884 (Fzo-like conserved region), IPR001019 (Guanine nucleotide binding protein (G-protein), alpha subunit)
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	tag-353	F25D7.2	n/a	chrI 10,401,993	C. elegans TAG-353 protein; contains similarity to Interpro domain IPR000626 (Ubiquitin)
4	C02C2.4	C02C2.4	n/a	chrIII 7,863,860	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
5	C01H6.4	C01H6.4	n/a	chrI 7,211,559	contains similarity to Pfam domains PF00070 (Pyridine nucleotide-disulphide oxidoreductase) , PF00743 (Flavin-binding monooxygenase-like) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR000759 (Adrenodoxin reductase), IPR000960 (Flavin-containing monooxygenase FMO), IPR000103 (Pyridine nucleotide-disulphide oxidoreductase, class-II), IPR001327 (Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region), IPR016040 (NAD(P)-binding), IPR001100 (Pyridine nucleotide-disulphide oxidoreductase, class I)
6	F01G4.3	F01G4.3	n/a	chrIV 11,138,937	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF08148 (DSHCT (NUC185) domain) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR016438 (RNA helicase, ATP-dependent, SK12/DOB1), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR012961 (DSH, C-terminal), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
7	stdh-3	C06B3.5	n/a	chrV 13,905,299	stdh-3 encodes a putative steroid dehydrogenase orthologous to human HSD17B3 (OMIM:605573, mutated in pseudohermaphroditism), HSD17B12 (OMIM:609574), and HSDL1, and paralogous to LET-767, STDH-1/-2, and STDH-4; STDH-3 has no obvious function in mass RNAi assays.
8	vpr-1	F33D11.11	n/a	chrI 5,869,119	C. elegans VPR-1 protein; contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein), IPR016763 (Vesicle-associated membrane protein)
9	T23H2.3	T23H2.3	n/a	chrI 6,444,050	contains similarity to Pfam domains PF00271 (Helicase conserved C-terminal domain) , PF00176 (SNF2 family N-terminal domain) contains similarity to Interpro domains IPR000330 (SNF2-related), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
10	cogc-8	R02D3.2	n/a	chrIV 242,340	cogc-8 encodes an ortholog of mammalian COG-8, a subunit of lobe B of the conserved oligomeric Golgi complex (COGC); COGC-8 is weakly required for normal gonadal distal tip cell migration, a process that also requires seven other orthologs of COGC subunits; like other lobe B subunits in both C. elegans and S. cerevisiae, COGC-8 is only partially required for normal function, while lobe A subunits are strongly required in either worms or yeast.
11	gly-3	ZK688.8	n/a	chrIII 7,916,183	gly-3 encodes an N-acetylgalactosaminyltransferase that is functional in vitro.
12	F49H6.3	F49H6.3	n/a	chrV 17,015,023	contains similarity to Pfam domain PF06653 Protein of unknown function (DUF1164) contains similarity to Interpro domain IPR009545 (Protein of unknown function DUF1164)
13	nduf-2.2	T26A5.3	n/a	chrIII 6,466,129	T26A5.3 encodes a predicted mitochondrial protein whose mature sequence has near-identity (95%) to GAS-1; T26A5.3 transcription is detectable by RT-PCR, but not visible by promoter-GFP fusion; however, a transgene containing a fusion of the gas-1 promoter to the T26A5.3 protein-coding sequence is able to fully rescue gas-1 mutants, indicating that T26A5.3 encodes a fully functional mitochondrial 49 kDa subunit that may rescue gas-1(fc21) mutants from lethality; mutants homozygous for a T26A5.3 deletion have normal anesthetic sensitivity and normal sensitivity to oxygen (unlike gas-1 mutants) but a shortened lifespan at normal laboratory oxygen levels (20%); animals doubly mutant for gas-1 and T26A5.3 have maternal-effect lethality, but sterile surviving parents are abnormally long-lived (2.7 times longer than wild-type and 4.2 times longer than gas-1 mutants); double mutants remain hypersensitive to oxygen.
14	Y47G7B.2	Y47G7B.2	n/a	chrII 2,706,989
15	F37C12.7	F37C12.7	n/a	chrIII 7,169,344	contains similarity to Pfam domain PF00501 AMP-binding enzyme contains similarity to Interpro domain IPR000873 (AMP-dependent synthetase and ligase)
16	F08F8.2	F08F8.2	n/a	chrIII 7,360,724	contains similarity to Pfam domain PF00368 Hydroxymethylglutaryl-coenzyme A reductase contains similarity to Interpro domains IPR004554 (Hydroxymethylglutaryl-CoA reductase, class I, catalytic), IPR009029 (Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding), IPR002202 (Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic)
17	ubxn-1	F23C8.4	n/a	chrI 2,434,821	C. elegans UBXN-1 protein; contains similarity to Pfam domains PF00789 (UBX domain) , PF00627 (UBA/TS-N domain) contains similarity to Interpro domains IPR001969 (Peptidase aspartic, active site), IPR000449 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal), IPR015940 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote), IPR001012 (UBX), IPR007087 (Zinc finger, C2H2-type)
18	T07A9.10	T07A9.10	n/a	chrIV 391,835	contains similarity to Pfam domain PF00995 Sec1 family contains similarity to Interpro domain IPR001619 (Sec1-like protein)
19	oxi-1	Y39A1C.2	n/a	chrIII 10,862,495	C. elegans OXI-1 protein; contains similarity to Pfam domain PF00632 HECT-domain (ubiquitin-transferase) contains similarity to Interpro domain IPR000569 (HECT)
20	clec-166	F38A1.5	n/a	chrIV 1,250,233	C. elegans CLEC-166 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
21	F30A10.10	F30A10.10	n/a	chrI 9,508,859	contains similarity to Pfam domains PF00443 (Ubiquitin carboxyl-terminal hydrolase) , PF02809 (Ubiquitin interaction motif) contains similarity to Interpro domain IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)
22	F57B10.1	F57B10.1	n/a	chrI 6,582,350	contains similarity to Pfam domains PF07716 (Basic region leucine zipper) , PF00170 (bZIP transcription factor) contains similarity to Interpro domains IPR002112 (Transcription factor Jun), IPR011700 (Basic leucine zipper), IPR004827 (Basic-leucine zipper (bZIP) transcription factor), IPR002227 (Tyrosinase), IPR008917 (Eukaryotic transcription factor, Skn-1-like, DNA-binding), IPR011616 (bZIP transcription factor, bZIP-1)
23	ZK180.4	ZK180.4	n/a	chrIV 4,512,601	contains similarity to Pfam domains PF00025 (ADP-ribosylation factor family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR006687 (GTP-binding protein SAR1), IPR013684 (Miro-like), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR006688 (ADP-ribosylation factor), IPR006689 (ARF/SAR superfamily)
24	C14C10.5	C14C10.5	n/a	chrV 12,603,773	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domains IPR011989 (Armadillo-like helical), IPR016024 (Armadillo-type fold)
25	C25H3.4	C25H3.4	n/a	chrII 5,692,793	contains similarity to Pfam domains PF01472 (PUA domain) , PF01253 (Translation initiation factor SUI1) contains similarity to Interpro domains IPR004521 (Uncharacterized domain 2), IPR015947 (PUA-like), IPR001950 (Translation initiation factor SUI1), IPR002478 (PUA)
26	ZK1010.2	ZK1010.2	n/a	chrIII 12,976,346	contains similarity to Pfam domain PF02582 Uncharacterised ACR, YagE family COG1723 contains similarity to Interpro domain IPR003734 (Protein of unknown function DUF155)
27	C13B9.3	C13B9.3	n/a	chrIII 6,623,764	C13B9.3 encodes a delta subunit of the coatomer (COPI) complex; in mass RNAi assays, C13B9.3 is required for fertility and general health.
28	prdx-3	R07E5.2	n/a	chrIII 4,407,867	C. elegans PRDX-3 protein; contains similarity to Pfam domains PF08534 (Redoxin) , PF00578 (AhpC/TSA family) contains similarity to Interpro domains IPR013740 (Redoxin), IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR000866 (Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)
29	clec-26	T20B3.12	n/a	chrV 16,849,392	C. elegans CLEC-26 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
30	T22B11.5	T22B11.5	n/a	chrIV 4,700,455	The T22B11.5 gene encodes an ortholog of the human gene OGDH, which when mutated leads to alpha-ketoglutarate deficiency (OMIM:203740); the T22B11.5 protein is predicted to be mitochondrial with 68% accuracy.
31	R08D7.1	R08D7.1	n/a	chrIII 8,966,795	contains similarity to Drosophila pseudoobscura GA12417-PA (Fragment).; TR:Q293H8
32	K02B12.3	K02B12.3	n/a	chrI 8,510,282	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
33	plc-4	R05G6.8	n/a	chrIV 7,511,060	C. elegans PLC-4 protein; contains similarity to Pfam domains PF00168 (C2 domain) , PF00387 (Phosphatidylinositol-specific phospholipase C, Y domain) , PF09279 (Phosphoinositide-specific phospholipase C, efhand-like) , PF00036 (EF hand) , PF00388 (Phosphatidylinositol-specific phospholipase C, X domain) contains similarity to Interpro domains IPR015359 (Phospholipase C, phosphoinositol-specific, EF-hand-like), IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR001192 (Phospholipase C, phosphoinositol-specific, C-terminal (PLC)), IPR001849 (Pleckstrin-like), IPR011993 (Pleckstrin homology-type), IPR000909 (Phospholipase C, phosphatidylinositol-specific , X region), IPR001711 (Phospholipase C, phosphatidylinositol-specific, Y domain), IPR013841 (Phospholipase C, phosphatidylinositol-specific , X and Y boxes), IPR000008 (C2 calcium-dependent membrane targeting)
34	mdh-1	F20H11.3	n/a	chrIII 6,607,404	mdh-1 encodes a homolog of malate dehydrogenase that is predicted to be mitochondrial.
35	D2096.11	D2096.11	n/a	chrIV 8,390,987	contains similarity to Pfam domains PF00307 (Calponin homology (CH) domain) (2), PF02187 (Growth-Arrest-Specific Protein 2 Domain) contains similarity to Interpro domains IPR003108 (Growth-arrest-specific protein 2), IPR002017 (Spectrin repeat), IPR016146 (Calponin-homology), IPR001715 (Calponin-like actin-binding)
36	btf-1	F15D4.1	n/a	chrII 13,207,846	btf-1 encodes a member of the TBP-associated family (TAF), with weak similarity to human TBP-associated factor 172.
37	M116.5	M116.5	n/a	chrIV 8,417,632	contains similarity to Pfam domains PF00307 (Calponin homology (CH) domain) (4), PF02187 (Growth-Arrest-Specific Protein 2 Domain) contains similarity to Interpro domains IPR003108 (Growth-arrest-specific protein 2), IPR002017 (Spectrin repeat), IPR016146 (Calponin-homology), IPR001715 (Calponin-like actin-binding), IPR001589 (Actinin-type, actin-binding, conserved site)
38	K06B9.4	K06B9.4	n/a	chrIV 4,192,228
39	C18E9.4	C18E9.4	n/a	chrII 8,964,490	C18E9.4 encodes the C. elegans ortholog of the NDUFB3/B12 subunit of the mitochondrial NADH dehydrogenase (ubiquinone) complex (complex I).
40	tba-1	F26E4.8	n/a	chrI 9,786,645	C. elegans TBA-1 protein; contains similarity to Pfam domains PF00091 (Tubulin/FtsZ family, GTPase domain) , PF03953 (Tubulin/FtsZ family, C-terminal domain) contains similarity to Interpro domains IPR002454 (Gamma tubulin), IPR002452 (Alpha tubulin), IPR002453 (Beta tubulin), IPR000217 (Tubulin), IPR003008 (Tubulin/FtsZ, GTPase), IPR004057 (Epsilon tubulin), IPR002967 (Delta tubulin), IPR000158 (Cell division protein FtsZ, N-terminal), IPR008280 (Tubulin/FtsZ, C-terminal)
41	sel-1	F45D3.5	n/a	chrV 12,562,037	sel-1 encodes two isoforms of a highly conserved transmembrane protein orthologous to human SEL1 (OMIM:602329) and Saccharomyces cerevisiae HRD3, a member of the HMG-CoA Reductase Degradation (HRD) complex that degrades malfolded endoplasmic reticulum (ER)-resident proteins; SEL-1 functions as a negative regulator of the LIN-12/GLP-1 Notch-like signaling pathway in C. elegans where it appears to function cell autonomously to regulate LIN-12 turnover; along with ABU-1, an ER-associated Type I transmembrane protein, SEL-1 may be a component of a cell survival pathway induced when unfolded proteins accumulate in the ER; SEL-1 is expressed throughout larval and adult stages of development, and detected in all tissues except the pharynx; within cells, SEL-1 appears to localize to intracellular vesicles, consistent with its proposed role in protein turnover.
42	cyp-25A1	C36A4.1	n/a	chrIII 3,833,539	C. elegans CYP-25A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
43	K02F3.10	K02F3.10	n/a	chrIII 851,885	contains similarity to Interpro domain IPR001412 (Aminoacyl-tRNA synthetase, class I, conserved site)
44	F54D5.14	F54D5.14	n/a	chrII 11,580,652	contains similarity to Pfam domain PF02463 RecF/RecN/SMC N terminal domain contains similarity to Interpro domain IPR003395 (RecF/RecN/SMC protein, N-terminal)
45	Y49G5A.1	Y49G5A.1	n/a	chrV 5,286,867	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domain IPR002223 (Proteinase inhibitor I2, Kunitz metazoa)
46	syn-16	ZC155.7	n/a	chrIII 5,208,372	C. elegans SYN-16 protein; contains similarity to Pfam domains PF00804 (Syntaxin) , PF05739 (SNARE domain) contains similarity to Interpro domains IPR010989 (t-SNARE), IPR006011 (Syntaxin, N-terminal), IPR000727 (Target SNARE coiled-coil region)
47	W02G9.4	W02G9.4	n/a	chrV 2,668,540	contains similarity to Pfam domain PF00431 CUB domain contains similarity to Interpro domain IPR000859 (CUB)
48	F48C1.6	F48C1.6	n/a	chrI 5,318,763
49	ZK6.8	ZK6.8	n/a	chrV 383,222	contains similarity to Pfam domain PF05978 Eukaryotic protein of unknown function (DUF895) contains similarity to Interpro domains IPR010291 (Protein of unknown function DUF895, eukaryotic), IPR016196 (MFS general substrate transporter)
50	fbf-2	F21H12.5	n/a	chrII 6,090,134	fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.