UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	IPP1	YBR011C	547	n/a	chrII 257,543	Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
2	TRP5	YGL026C	547	n/a	chrVII 447,473	Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis regulated by the general control system of amino acid biosynthesis
3	CHS1	YNL192W	547	n/a	chrXIV 278,199	Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin required for repairing the chitin septum during cytokinesis transcription activated by mating factor
4	ERG20	YJL167W	547	n/a	chrX 105,543	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
5	SBP1	YHL034C	547	n/a	chrVIII 33,635	Putative RNA binding protein involved in translational repression and found in cytoplasmic P bodies found associated with small nucleolar RNAs snR10 and snR11
6	HOM2	YDR158W	547	n/a	chrIV 770,905	Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis
7	GFA1	YKL104C	547	n/a	chrXI 244,296	Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis
8	TAL1	YLR354C	547	n/a	chrXII 836,853	Transaldolase, enzyme in the non-oxidative pentose phosphate pathway converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
9	ERD2	YBL040C	547	n/a	chrII 142,490	HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum has a role in maintenance of normal levels of ER-resident proteins
10	SEC18	YBR080C	547	n/a	chrII 399,752	ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion releases Sec17p from SNAP complexes has similarity to mammalian NSF
11	EPT1	YHR123W	547	n/a	chrVIII 355,448	sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase not essential for viability
12	CDC10	YCR002C	547	n/a	chrIII 117,864	Component of the septin ring that is required for cytokinesis septins recruit proteins to the mother-bud neck and can act as a barrier to diffusion at the membrane, and they comprise the 10 nm filaments seen with EM required for the transition from a single to double septin ring
13	KAR4	YCL055W	547	0	chrIII 28,432	Transcription factor required for gene regulation in response to pheromones also required during meiosis exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone
14	TRR1	YDR353W	547	n/a	chrIV 1,183,778	Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress
15	HOM6	YJR139C	547	n/a	chrX 689,984	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis enzyme has nucleotide-binding, dimerization and catalytic regions
16	ACB1	YGR037C	547	n/a	chrVII 559,862	Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes subject to starvation-induced, Grh1p-mediated unconventional secretion
17	FPR2	YDR519W	547	n/a	chrIV 1,480,628	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin expression pattern suggests possible involvement in ER protein trafficking
18	KRE6	YPR159W	547	n/a	chrXVI 858,664	Type II integral membrane protein required for beta-1,6 glucan biosynthesis putative beta-glucan synthase localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles functionally redundant with Skn1p
19	KTR2	YKR061W	547	n/a	chrXI 558,315	Mannosyltransferase involved in N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family
20	LHS1	YKL073W	547	n/a	chrXI 297,752	Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p regulated by the unfolded protein response pathway
21	DSF2	YBR007C	547	n/a	chrII 249,911	Deletion suppressor of mpt5 mutation
22	YBR096W	YBR096W	547	n/a	chrII 436,367	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the ER
23	IFA38	YBR159W	547	n/a	chrII 559,206	Microsomal beta-keto-reductase contains oleate response element (ORE) sequence in the promoter region mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
24	GND1	YHR183W	547	n/a	chrVIII 471,694	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
25	RPN1	YHR027C	547	n/a	chrVIII 163,220	Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome may participate in the recognition of several ligands of the proteasome contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions
26	SOL3	YHR163W	547	n/a	chrVIII 424,098	6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway weak multicopy suppressor of los1-1 mutation homologous to Sol2p and Sol1p
27	ELO1	YJL196C	547	n/a	chrX 68,316	Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
28	GLR1	YPL091W	547	n/a	chrXVI 376,227	Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione mitochondrial but not cytosolic form has a role in resistance to hyperoxia
29	YNL320W	YNL320W	547	n/a	chrXIV 38,127	Putative protein of unknown function the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
30	DUG1	YFR044C	547	n/a	chrVI 240,714	Cys-Gly metallo-di-peptidase forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
31	YJL171C	YJL171C	547	n/a	chrX 100,299	GPI-anchored cell wall protein of unknown function induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein
32	RET3	YPL010W	547	n/a	chrXVI 535,302	Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles involved in retrograde transport between Golgi and ER
33	YDR210W	YDR210W	547	n/a	chrIV 871,187	Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module related proteins in other organisms may be involved in response to stress green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
34	OYE2	YHR179W	547	n/a	chrVIII 463,103	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with different ligand binding and catalytic properties may be involved in sterol metabolism, oxidative stress response, and programmed cell death
35	ARG7	YMR062C	547	n/a	chrXIII 395,716	Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
36	YDR266C	YDR266C	547	n/a	chrIV 1,001,063	Protein of unknown function that may interact with ribosomes, based on co-purification experiments green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm contains a RING finger domain
37	YLR301W	YLR301W	547	n/a	chrXII 731,192	Protein of unknown function that interacts with Sec72p and Hrr25p
38	GSH2	YOL049W	547	n/a	chrXV 239,356	Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine induced by oxidative stress and heat shock
39	PAA1	YDR071C	547	n/a	chrIV 589,114	Polyamine acetyltransferase acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine) may be involved in transcription and/or DNA replication
40	YDR209C	YDR209C	547	n/a	chrIV 871,242	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data partially overlaps uncharacterized gene YDR210W.
41	YNL043C	YNL043C	547	n/a	chrXIV 545,749	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data partially overlaps the verified gene YIP3/YNL044W