UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ref-1	T01E8.2	7.999999999999999e-146	chrII 10,219,169	ref-1 encodes a protein with two basic helix-loop-helix (bHLH) domains that is distantly related to the hairy/Enhancer of split subfamily of bHLH transcription factors; REF-1 is required in hermaphrodites during early larval development for regulating the pattern of posterior Pn.p hypodermal cell fusions, primarily through regulation of MAB-5 homeodomain protein activity; REF-1 is also required for head morphogenesis and specification of the V6 lateral seam cell fate; in males, ref-1 is a target of MAB-3 transcriptional repression which in turn, promotes expression of LIN-32, a proneural bHLH transcription factor.
2	F46F5.14	F46F5.14	n/a	chrII 800,774	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
3	str-171	T01G5.5	n/a	chrV 15,131,482	C. elegans STR-171 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
4	F15D4.2	F15D4.2	n/a	chrII 13,216,307	contains similarity to Strongylocentrotus purpuratus Protein ENDO16 (Fragment).; SW:P13665
5	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
6	C42C1.2	C42C1.2	n/a	chrIV 12,266,886	contains similarity to Pfam domain PF00481 Protein phosphatase 2C contains similarity to Interpro domains IPR001932 (Protein phosphatase 2C-related), IPR000222 (), IPR014045 (Protein phosphatase 2C, N-terminal), IPR015655 (Protein phosphatase 2C)
7	srp-2	C05E4.1	n/a	chrV 763,702	srp-2 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily that is orthologous to human NEUROSERPIN (OMIM:602445, mutated in familial encephalopathy with neuroserpin inclusion bodies); SRP-2 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases, and in vitro, recombinant SRP-2 is able to inhibit granzyme B activity; however, as loss of srp-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-2 in C. elegans development and/or behavior is not yet known; srp-2 expression is detected in hypodermal cells, particularly in the lateral seam cells.
8	acl-1	F59F4.4	n/a	chrX 15,850,758	acl-1 encodes a 1-acyl-sn-glycerol-3-phosphate acyltransferase; ACL-1 is predicted to be a membrane protein that plays a role in phospholipid biosynthesis, but as loss of acl-1 activity via large-scale RNAi experiments results in no obvious defects, the precise role of ACL-1 in C. elegans development and/or behavior is not yet known.
9	spp-6	T08A9.10	n/a	chrX 7,317,449	spp-6 encodes a predicted transmembrane protein containing a saposin (B) domain that is a member of a saposin-like protein superfamily containing mammalian NK-lysin and granulysin and the protozoan amoebapores; SPP-6 is predicted to function as a lipid-binding protein that may possess pore-forming, cytotoxic activity; as loss of SPP-6 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of SPP-6 in C. elegans development and/or behavior is not yet known.
10	C01G6.4	C01G6.4	n/a	chrII 9,272,092	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
11	K08D9.6	K08D9.6	n/a	chrV 3,233,173	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008167 (Protein of unknown function DUF23, C-terminal), IPR008166 (Protein of unknown function DUF23)
12	R08H2.8	R08H2.8	n/a	chrV 15,371,455	contains similarity to Mycoplasma penetrans Conserved hypothetical protein.; TR:Q8EV71
13	grl-3	K03B8.7	n/a	chrV 11,411,850	grl-3 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-3 is expressed in intestine, larval renal gland cells, and larval neurons; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
14	Y57G11B.1	Y57G11B.1	n/a	chrIV 14,550,857	contains similarity to Trichomonas vaginalis G3 Viral A-type inclusion protein, putative.; TR:A2EJ43
15	F53F4.4	F53F4.4	n/a	chrV 13,596,162	contains similarity to Candida albicans Chitinase 3 precursor (EC 3.2.1.14).; SW:CHI3_CANAL
16	nhr-37	F44C4.2	n/a	chrV 6,623,464	C. elegans NHR-37 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
17	lgc-9	C04C3.2	n/a	chrIV 3,417,455	C. elegans LGC-9 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
18	F57E7.2	F57E7.2	n/a	chrV 16,482,980	contains similarity to Psilotum nudum Hypothetical protein.; TR:Q8WHW9
19	clec-249	Y51A2A.7	n/a	chrV 18,304,784	C. elegans CLEC-249 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
20	srd-4	ZK863.5	n/a	chrV 12,185,574	C. elegans SRD-4 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR000276 (GPCR, rhodopsin-like)
21	F17E9.2	F17E9.2	n/a	chrIV 8,356,187
22	Y57G11C.18	Y57G11C.18	n/a	chrIV 14,841,760	contains similarity to Interpro domain IPR000767 (Disease resistance protein)
23	C16C4.1	C16C4.1	n/a	chrII 1,894,512
24	R09D1.1	R09D1.1	n/a	chrII 9,442,815	contains similarity to Pfam domain PF00704 Glycosyl hydrolases family 18 contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR001223 (Glycoside hydrolase, family 18, catalytic domain), IPR013781 (Glycoside hydrolase, subgroup, catalytic core)
25	tag-199	F45E4.4	n/a	chrIV 7,612,783	C. elegans TAG-199 protein ; contains similarity to Trypanosoma brucei Putative uncharacterized protein.; TR:Q4GZ45
26	C50B6.1	C50B6.1	n/a	chrV 13,308,835	contains similarity to Synechocystis sp Hypothetical protein slr1813.; TR:P73698
27	H43I07.1	H43I07.1	n/a	chrV 4,206,564	contains similarity to Interpro domains IPR010754 (Optic atrophy 3-like), IPR005819 (Histone H5)
28	F58H7.7	F58H7.7	n/a	chrIV 911,281	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
29	T13F2.6	T13F2.6	n/a	chrIV 9,779,719
30	ZK673.4	ZK673.4	n/a	chrII 10,453,965	ZK673.4 encodes a protein with a THAP or THAP-like domain; other proteins with such domains include LIN-15A, LIN-15B, LIN-36, and HIM-17 (which all interact with LIN-35/Rb), as well as CDC-14B, CTB-1, GON-14, and ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1.
31	F57A8.4	F57A8.4	n/a	chrV 10,067,924	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
32	fbxb-35	F07E5.2	n/a	chrII 2,052,208	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
33	Y38H6C.21	Y38H6C.21	n/a	chrV 20,550,079	contains similarity to Aquifex aeolicus Flagellar biosynthetic protein flhB.; SW:FLHB_AQUAE
34	F20D1.7	F20D1.7	n/a	chrX 14,989,294	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR001611 (Leucine-rich repeat), IPR013783 (Immunoglobulin-like fold), IPR003591 (Leucine-rich repeat, typical subtype), IPR007110 (Immunoglobulin-like)
35	lgg-3	B0336.8	n/a	chrIII 5,697,730	lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities.
36	sdz-2	C08A9.7	n/a	chrX 17,099,848	C. elegans SDZ-2 protein; contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
37	Y6E2A.4	Y6E2A.4	n/a	chrV 15,713,920	contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core), IPR002219 (Protein kinase C, phorbol ester/diacylglycerol binding)
38	K09D9.9	K09D9.9	n/a	chrV 3,993,382
39	T15D6.7	T15D6.7	n/a	chrI 12,387,268	contains similarity to Pfam domain PF03360 Glycosyltransferase family 43 contains similarity to Interpro domain IPR005027 (Glycosyl transferase, family 43)
40	try-2	C07G1.1	n/a	chrIV 8,213,133	try-2 encodes a homolog of human TRYP1 and ELA2; mutation of human TRYP1 or ELA2 leads, respectively, to hereditary pancreatitis (OMIM:276000) or cyclic haematopoiesis (OMIM:162800).
41	E03H4.5	E03H4.5	n/a	chrI 12,414,766	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
42	his-8	F45F2.12	n/a	chrV 8,532,878	his-8 encodes an H2B histone; his-8 is contained within the histone gene cluster HIS2.
43	T19H5.4	T19H5.4	n/a	chrII 9,487,245	contains similarity to Gallus gallus Homeobox prospero-like protein PROX1 (PROX 1).; SW:PRX1_CHICK
44	C47D12.5	C47D12.5	n/a	chrII 11,685,843
45	str-135	F21F8.10	n/a	chrV 8,280,076	C. elegans STR-135 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
46	fbxa-69	F54B8.3	n/a	chrV 15,815,021	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
47	nhr-188	F47C10.7	n/a	chrV 3,857,080	C. elegans NHR-188 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
48	H12D21.3	H12D21.3	n/a	chrV 14,886,000	contains similarity to Plasmodium cynomolgi Circumsporozoite protein precursor (CS).; SW:P08675
49	Y40H7A.11	Y40H7A.11	n/a	chrIV 15,219,977	contains similarity to Interpro domain IPR006629 (LPS-induced tumor necrosis factor alpha factor)
50	C07D10.1	C07D10.1	n/a	chrII 7,399,714	contains similarity to Pfam domain PF00646 F-box domain contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)