UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	HIS1	YER055C	481	n/a	chrV 265,338	ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts transcription is regulated by general amino acid control
2	ILV1	YER086W	481	n/a	chrV 329,342	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis expression is under general amino acid control ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
3	RAS1	YOR101W	481	n/a	chrXV 515,708	GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation localized to the plasma membrane homolog of mammalian RAS proto-oncogenes
4	HTB2	YBL002W	481	n/a	chrII 236,689	Histone H2B, core histone protein required for chromatin assembly and chromosome function nearly identical to HTB1 Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
5	HHF1	YBR009C	481	n/a	chrII 255,528	Histone H4, core histone protein required for chromatin assembly and chromosome function one of two identical histone proteins (see also HHF2) contributes to telomeric silencing N-terminal domain involved in maintaining genomic integrity
6	HHF2	YNL030W	481	n/a	chrXIV 576,882	Histone H4, core histone protein required for chromatin assembly and chromosome function one of two identical histone proteins (see also HHF1) contributes to telomeric silencing N-terminal domain involved in maintaining genomic integrity
7	HTA2	YBL003C	481	n/a	chrII 235,593	Histone H2A, core histone protein required for chromatin assembly and chromosome function one of two nearly identical (see also HTA1) subtypes DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair acetylated by Nat4p
8	RPL41A	YDL184C	481	n/a	chrIV 130,445	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein comprised of only 25 amino acids rpl41a rpl41b double null mutant is viable
9	ILV5	YLR355C	481	n/a	chrXII 838,659	Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA found in mitochondrial nucleoids
10	ADE5,7	YGL234W	481	n/a	chrVII 57,686	Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
11	CDC33	YOL139C	481	n/a	chrXV 60,703	Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p)
12	DFR1	YOR236W	481	n/a	chrXV 781,223	Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function
13	SAM1	YLR180W	481	n/a	chrXII 515,836	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine one of two differentially regulated isozymes (Sam1p and Sam2p)
14	HOM3	YER052C	481	n/a	chrV 257,166	Aspartate kinase (L-aspartate 4-P-transferase) cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis
15	FCY2	YER056C	481	n/a	chrV 267,312	Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation
16	SAM2	YDR502C	481	n/a	chrIV 1,453,887	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine one of two differentially regulated isozymes (Sam1p and Sam2p)
17	CYS4	YGR155W	481	0	chrVII 799,304	Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis responsible for hydrogen sulfide generation mutations in human ortholog cause homocystinuria
18	GSP1	YLR293C	481	n/a	chrXII 721,100	Ran GTPase, GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p yeast Gsp2p homolog
19	HIS7	YBR248C	481	n/a	chrII 715,636	Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
20	GLY1	YEL046C	481	n/a	chrV 68,210	Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine involved in glycine biosynthesis
21	YMC2	YBR104W	481	n/a	chrII 450,161	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis member of the mitochondrial carrier (MCF) family has similarity with Ymc1p
22	BAT1	YHR208W	481	n/a	chrVIII 518,122	Mitochondrial branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA biosynthesis homolog of murine ECA39 highly expressed during logarithmic phase and repressed during stationary phase
23	TIF11	YMR260C	481	n/a	chrXIII 789,608	Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon C-terminus associates with Fun12p (eIF5B) N terminus interacts with eIF2 and eIF3
24	ACO2	YJL200C	481	n/a	chrX 57,628	Putative mitochondrial aconitase isozyme similarity to Aco1p, an aconitase required for the TCA cycle expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
25	ALD5	YER073W	481	n/a	chrV 304,811	Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation activated by K+ utilizes NADP+ as the preferred coenzyme constitutively expressed
26	FTR1	YER145C	481	n/a	chrV 461,133	High affinity iron permease involved in the transport of iron across the plasma membrane forms complex with Fet3p expression is regulated by iron
27	ALG5	YPL227C	481	n/a	chrXVI 120,665	UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
28	ALA1	YOR335C	481	n/a	chrXV 947,671	Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis point mutation (cdc64-1 allele) causes cell cycle arrest at G1 lethality of null mutation is functionally complemented by human homolog
29	CCT7	YJL111W	481	n/a	chrX 208,703	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo mutant has increased aneuploidy tolerance
30	IRC7	YFR055W	481	n/a	chrVI 264,715	Beta-lyase involved in the production of thiols null mutant displays increased levels of spontaneous Rad52p foci expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner
31	YGL101W	YGL101W	481	n/a	chrVII 312,516	Putative protein of unknown function non-essential gene with similarity to YBR242W interacts with the DNA helicase Hpr5p
32	LSG1	YGL099W	481	n/a	chrVII 315,592	Putative GTPase involved in 60S ribosomal subunit biogenesis required for the release of Nmd3p from 60S subunits in the cytoplasm
33	NMA111	YNL123W	481	n/a	chrXIV 396,181	Serine protease and general molecular chaperone involved in response to heat stress and promotion of apoptosis may contribute to lipid homeostasis sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
34	VTC3	YPL019C	481	n/a	chrXVI 515,764	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
35	YHM2	YMR241W	481	n/a	chrXIII 752,433	Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents also associates with mt nucleoids and has a role in replication and segregation of the mt genome
36	ODC2	YOR222W	481	n/a	chrXV 758,791	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
37	HRP1	YOL123W	481	n/a	chrXV 88,646	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences